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- Publisher Website: 10.1016/j.neurobiolaging.2023.10.002
- Scopus: eid_2-s2.0-85175292560
- PMID: 37913627
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Article: Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease
Title | Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease |
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Authors | |
Keywords | Alzheimer's disease Brain imaging Cerebral spinal fluid (CSF) biomarker Cognitive and functional outcome Sex-based disparity |
Issue Date | 1-Jan-2024 |
Publisher | Elsevier |
Citation | Neurobiology of Aging, 2024, v. 133, p. 67-77 How to Cite? |
Abstract | Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. Two of 3 patients with AD are biologically female; therefore, the biological underpinnings of this diagnosis disparity may inform interventions slowing the AD progression. To bridge this gap, we conducted analyses of 1078 male and female participants from the Alzheimer's Disease Neuroimaging Initiative to examine associations between levels of cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes. The Chow test was used to quantify sex differences by determining if biological sex affects relationships between the studied biomarkers and outcomes. Multiple magnetic resonance imaging (whole brain, entorhinal cortex, middle temporal gyrus, fusiform gyrus, hippocampus), position emission tomography (AV45), and CSF (P-TAU, TAU) biomarkers were differentially associated with cognitive and functional outcomes. Post-hoc bootstrapped and association analyses confirmed these differential effects and emphasized the necessity of using separate, sex-stratified models. The studied imaging/CSF biomarkers may account for some of the sex-based variation in AD pathophysiology. The identified sex-varying relationships between CSF/imaging biomarkers and cognitive/functional outcomes warrant future biological investigation in independent cohorts. |
Persistent Identifier | http://hdl.handle.net/10722/347314 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.488 |
DC Field | Value | Language |
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dc.contributor.author | Lee, Brian N | - |
dc.contributor.author | Wang, Junwen | - |
dc.contributor.author | Hall, Molly A | - |
dc.contributor.author | Kim, Dokyoon | - |
dc.contributor.author | Stites, Shana D | - |
dc.contributor.author | Shen, Li | - |
dc.date.accessioned | 2024-09-21T00:30:53Z | - |
dc.date.available | 2024-09-21T00:30:53Z | - |
dc.date.issued | 2024-01-01 | - |
dc.identifier.citation | Neurobiology of Aging, 2024, v. 133, p. 67-77 | - |
dc.identifier.issn | 0197-4580 | - |
dc.identifier.uri | http://hdl.handle.net/10722/347314 | - |
dc.description.abstract | <p>Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. Two of 3 patients with AD are biologically female; therefore, the biological underpinnings of this diagnosis disparity may inform interventions slowing the AD progression. To bridge this gap, we conducted analyses of 1078 male and female participants from the Alzheimer's Disease Neuroimaging Initiative to examine associations between levels of cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes. The Chow test was used to quantify sex differences by determining if biological sex affects relationships between the studied biomarkers and outcomes. Multiple magnetic resonance imaging (whole brain, entorhinal cortex, middle temporal gyrus, fusiform gyrus, hippocampus), position emission tomography (AV45), and CSF (P-TAU, TAU) biomarkers were differentially associated with cognitive and functional outcomes. Post-hoc bootstrapped and association analyses confirmed these differential effects and emphasized the necessity of using separate, sex-stratified models. The studied imaging/CSF biomarkers may account for some of the sex-based variation in AD pathophysiology. The identified sex-varying relationships between CSF/imaging biomarkers and cognitive/functional outcomes warrant future biological investigation in independent cohorts.</p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Neurobiology of Aging | - |
dc.subject | Alzheimer's disease | - |
dc.subject | Brain imaging | - |
dc.subject | Cerebral spinal fluid (CSF) biomarker | - |
dc.subject | Cognitive and functional outcome | - |
dc.subject | Sex-based disparity | - |
dc.title | Sex modifies effects of imaging and CSF biomarkers on cognitive and functional outcomes: a study of Alzheimer's disease | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.neurobiolaging.2023.10.002 | - |
dc.identifier.pmid | 37913627 | - |
dc.identifier.scopus | eid_2-s2.0-85175292560 | - |
dc.identifier.volume | 133 | - |
dc.identifier.spage | 67 | - |
dc.identifier.epage | 77 | - |
dc.identifier.issnl | 0197-4580 | - |