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Article: A differential-targeting core-shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration

TitleA differential-targeting core-shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration
Authors
Issue Date11-Apr-2024
PublisherRoyal Society of Chemistry
Citation
Materials Horizons, 2024, v. 11, n. 11, p. 2667-2684 How to Cite?
AbstractMicroneedles for skin regeneration are conventionally restricted by uncontrollable multi-drug release, limited types of drugs, and poor wound adhesion. Here, a novel core-shell microneedle patch is developed for scarless skin repair, where the shell is composed of hydrophilic gelatin methacryloyl (GelMA) loaded with mangiferin, an anti-inflammatory small molecule, and the core is composed of hydrophobic poly (lactide-co-propylene glycol-co-lactide) dimethacrylates (PGLADMA) loaded with bioactive macromolecule and human mesenchymal stromal cell (hMSC)-derived exosomes. This material choice provides several benefits: the GelMA shell provides a swelling interface for tissue interlocking and rapid release of mangiferin at an early wound healing stage for anti-inflammation, whereas the PGLADMA core offers long-term encapsulation and release of exosomes (30% release in 3 weeks), promoting sustained angiogenesis and anti-inflammation. Our results demonstrate that the core-shell microneedle possesses anti-inflammatory properties and can induce angiogenesis both in vitro in terms of macrophage polarization and tube formation of human umbilical vein endothelial cells (HUVECs), and in vivo in terms of anti-inflammation, re-epithelization, and vessel formation. Importantly, we also observe reduced scar formation in vivo. Altogether, the degradation dynamics of our hydrophilic/hydrophobic materials enable the design of a core-shell microneedle for differential and prolonged release, promoting scarless skin regeneration, with potential for other therapies of long-term exosome release.
Persistent Identifierhttp://hdl.handle.net/10722/346277
ISSN
2023 Impact Factor: 12.2
2023 SCImago Journal Rankings: 3.376

 

DC FieldValueLanguage
dc.contributor.authorLyu, Shang-
dc.contributor.authorLiu, Qi-
dc.contributor.authorYuen, Ho Yin-
dc.contributor.authorXie, Huizhi-
dc.contributor.authorYang, Yuhe-
dc.contributor.authorYeung, Kelvin Wai Kwok-
dc.contributor.authorTang, Chak Yin-
dc.contributor.authorWang, Shuqi-
dc.contributor.authorLiu, Yaxiong-
dc.contributor.authorLi, Bin-
dc.contributor.authorHe, Yong-
dc.contributor.authorZhao, Xin-
dc.date.accessioned2024-09-13T00:30:09Z-
dc.date.available2024-09-13T00:30:09Z-
dc.date.issued2024-04-11-
dc.identifier.citationMaterials Horizons, 2024, v. 11, n. 11, p. 2667-2684-
dc.identifier.issn2051-6347-
dc.identifier.urihttp://hdl.handle.net/10722/346277-
dc.description.abstractMicroneedles for skin regeneration are conventionally restricted by uncontrollable multi-drug release, limited types of drugs, and poor wound adhesion. Here, a novel core-shell microneedle patch is developed for scarless skin repair, where the shell is composed of hydrophilic gelatin methacryloyl (GelMA) loaded with mangiferin, an anti-inflammatory small molecule, and the core is composed of hydrophobic poly (lactide-co-propylene glycol-co-lactide) dimethacrylates (PGLADMA) loaded with bioactive macromolecule and human mesenchymal stromal cell (hMSC)-derived exosomes. This material choice provides several benefits: the GelMA shell provides a swelling interface for tissue interlocking and rapid release of mangiferin at an early wound healing stage for anti-inflammation, whereas the PGLADMA core offers long-term encapsulation and release of exosomes (30% release in 3 weeks), promoting sustained angiogenesis and anti-inflammation. Our results demonstrate that the core-shell microneedle possesses anti-inflammatory properties and can induce angiogenesis both in vitro in terms of macrophage polarization and tube formation of human umbilical vein endothelial cells (HUVECs), and in vivo in terms of anti-inflammation, re-epithelization, and vessel formation. Importantly, we also observe reduced scar formation in vivo. Altogether, the degradation dynamics of our hydrophilic/hydrophobic materials enable the design of a core-shell microneedle for differential and prolonged release, promoting scarless skin regeneration, with potential for other therapies of long-term exosome release.-
dc.languageeng-
dc.publisherRoyal Society of Chemistry-
dc.relation.ispartofMaterials Horizons-
dc.titleA differential-targeting core-shell microneedle patch with coordinated and prolonged release of mangiferin and MSC-derived exosomes for scarless skin regeneration-
dc.typeArticle-
dc.identifier.doi10.1039/d3mh01910a-
dc.identifier.pmid38669042-
dc.identifier.scopuseid_2-s2.0-85191774260-
dc.identifier.volume11-
dc.identifier.issue11-
dc.identifier.spage2667-
dc.identifier.epage2684-
dc.identifier.eissn2051-6355-
dc.identifier.issnl2051-6347-

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