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Article: Oxytocin receptor gene polymorphism (rs53576) and depressive symptoms: a systematic review and meta-analysis
Title | Oxytocin receptor gene polymorphism (rs53576) and depressive symptoms: a systematic review and meta-analysis |
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Authors | |
Keywords | Depression Depressive symptoms Meta-analysis Oxytocin Oxytocin receptor gene rs53576 genotype |
Issue Date | 1-Jan-2024 |
Publisher | Springer |
Citation | Current Psychology, 2024, v. 43, n. 29, p. 24365-24374 How to Cite? |
Abstract | Oxytocin receptor gene polymorphism (OXTR rs53576) is associated with human social cognition and behavior. However, results on the contribution of OXTR rs53576 to individual differences in depressive symptoms have been inconsistent. This meta-analysis examined the association between OXTR rs53576 and depressive symptoms and under what conditions this association might hold true. A systematic search of PubMed, PsycInfo, and Web of Science was performed for English articles describing human-based studies from the inception of the databases to February 2023, as well as a manual search of the reference lists of the included articles. The search terms included OXTR rs53576, depressive symptoms, and their synonyms. Standardized mean differences in depressive symptoms between individuals classified by OXTR rs53576 genotypes were evaluated, and random-effects meta-analyses were performed. A total of 10 studies including 2972 subjects from six countries were pooled. Results provided no evidence of an association between OXTR rs53576 and depressive symptoms. The between-study differences in I2 statistics by ethnicity, disease history, and age group suggested the presence of moderating variables. However, the number of eligible studies was small with considerable heterogeneity. Findings underscore the importance of homogeneous sampling for research on depression genetics to affirm the association between OXTR rs35376 and depressive symptoms. |
Persistent Identifier | http://hdl.handle.net/10722/346254 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 1.001 |
DC Field | Value | Language |
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dc.contributor.author | Wong, Rosa S. | - |
dc.contributor.author | Chan, Yannis W.K. | - |
dc.contributor.author | Tung, Keith T.S. | - |
dc.date.accessioned | 2024-09-12T09:10:15Z | - |
dc.date.available | 2024-09-12T09:10:15Z | - |
dc.date.issued | 2024-01-01 | - |
dc.identifier.citation | Current Psychology, 2024, v. 43, n. 29, p. 24365-24374 | - |
dc.identifier.issn | 1046-1310 | - |
dc.identifier.uri | http://hdl.handle.net/10722/346254 | - |
dc.description.abstract | Oxytocin receptor gene polymorphism (OXTR rs53576) is associated with human social cognition and behavior. However, results on the contribution of OXTR rs53576 to individual differences in depressive symptoms have been inconsistent. This meta-analysis examined the association between OXTR rs53576 and depressive symptoms and under what conditions this association might hold true. A systematic search of PubMed, PsycInfo, and Web of Science was performed for English articles describing human-based studies from the inception of the databases to February 2023, as well as a manual search of the reference lists of the included articles. The search terms included OXTR rs53576, depressive symptoms, and their synonyms. Standardized mean differences in depressive symptoms between individuals classified by OXTR rs53576 genotypes were evaluated, and random-effects meta-analyses were performed. A total of 10 studies including 2972 subjects from six countries were pooled. Results provided no evidence of an association between OXTR rs53576 and depressive symptoms. The between-study differences in I2 statistics by ethnicity, disease history, and age group suggested the presence of moderating variables. However, the number of eligible studies was small with considerable heterogeneity. Findings underscore the importance of homogeneous sampling for research on depression genetics to affirm the association between OXTR rs35376 and depressive symptoms. | - |
dc.language | eng | - |
dc.publisher | Springer | - |
dc.relation.ispartof | Current Psychology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Depression | - |
dc.subject | Depressive symptoms | - |
dc.subject | Meta-analysis | - |
dc.subject | Oxytocin | - |
dc.subject | Oxytocin receptor gene | - |
dc.subject | rs53576 genotype | - |
dc.title | Oxytocin receptor gene polymorphism (rs53576) and depressive symptoms: a systematic review and meta-analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s12144-024-06110-5 | - |
dc.identifier.scopus | eid_2-s2.0-85192906567 | - |
dc.identifier.volume | 43 | - |
dc.identifier.issue | 29 | - |
dc.identifier.spage | 24365 | - |
dc.identifier.epage | 24374 | - |
dc.identifier.eissn | 1936-4733 | - |
dc.identifier.issnl | 1046-1310 | - |