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Article: Conceptual-level disgust conditioning in contamination-based obsessive-compulsive disorder

TitleConceptual-level disgust conditioning in contamination-based obsessive-compulsive disorder
Authors
Keywordsconcept
contamination
disgust
obsessive-compulsive disorder
Pavlovian conditioning
Issue Date26-Jun-2024
PublisherWiley
Citation
Psychophysiology, 2024 How to Cite?
AbstractPavlovian fear conditioning and extinction represent learning mechanisms underlying exposure-based interventions. While increasing evidence indicates a pivotal role of disgust in the development of contamination-based obsessive-compulsive disorder (C-OCD), dysregulations in conditioned disgust acquisition and maintenance, in particular driven by higher-order conceptual processes, have not been examined. Here, we address this gap by exposing individuals with high (HCC, n = 41) or low (LCC, n = 41) contamination concern to a conceptual-level disgust conditioning and extinction paradigm. Conditioned stimuli (CS+) were images from one conceptual category partially reinforced by unconditioned disgust-eliciting stimuli (US), while images from another category served as non-reinforced conditioned stimuli (CS−). Skin conductance responses (SCRs), US expectancy and CS valence ratings served as primary outcomes to quantify conditioned disgust responses. Relative to LCC, HCC individuals exhibited increased US expectancy and CS+ disgust experience, but comparable SCR levels following disgust acquisition. Despite a decrease in conditioned responses from the acquisition phase to the extinction phase, both groups did not fully extinguish the learned disgust. Importantly, the extinction resilience of acquired disgust was more pronounced in HCC individuals. Together, our findings suggest that individuals with high self-reported contamination concern exhibit increased disgust acquisition and resistance to extinction. The findings provide preliminary evidence on how dysregulated disgust learning mechanism across semantically related concepts may contribute to C-OCD.
Persistent Identifierhttp://hdl.handle.net/10722/346124
ISSN
2023 Impact Factor: 2.9
2023 SCImago Journal Rankings: 1.303

 

DC FieldValueLanguage
dc.contributor.authorWang, Jinxia-
dc.contributor.authorBecker, Benjamin-
dc.contributor.authorWang, Yizhen-
dc.contributor.authorMing, Xianchao-
dc.contributor.authorLei, Yi-
dc.contributor.authorWikgren, Jan-
dc.date.accessioned2024-09-10T00:30:38Z-
dc.date.available2024-09-10T00:30:38Z-
dc.date.issued2024-06-26-
dc.identifier.citationPsychophysiology, 2024-
dc.identifier.issn0048-5772-
dc.identifier.urihttp://hdl.handle.net/10722/346124-
dc.description.abstractPavlovian fear conditioning and extinction represent learning mechanisms underlying exposure-based interventions. While increasing evidence indicates a pivotal role of disgust in the development of contamination-based obsessive-compulsive disorder (C-OCD), dysregulations in conditioned disgust acquisition and maintenance, in particular driven by higher-order conceptual processes, have not been examined. Here, we address this gap by exposing individuals with high (HCC, n = 41) or low (LCC, n = 41) contamination concern to a conceptual-level disgust conditioning and extinction paradigm. Conditioned stimuli (CS+) were images from one conceptual category partially reinforced by unconditioned disgust-eliciting stimuli (US), while images from another category served as non-reinforced conditioned stimuli (CS−). Skin conductance responses (SCRs), US expectancy and CS valence ratings served as primary outcomes to quantify conditioned disgust responses. Relative to LCC, HCC individuals exhibited increased US expectancy and CS+ disgust experience, but comparable SCR levels following disgust acquisition. Despite a decrease in conditioned responses from the acquisition phase to the extinction phase, both groups did not fully extinguish the learned disgust. Importantly, the extinction resilience of acquired disgust was more pronounced in HCC individuals. Together, our findings suggest that individuals with high self-reported contamination concern exhibit increased disgust acquisition and resistance to extinction. The findings provide preliminary evidence on how dysregulated disgust learning mechanism across semantically related concepts may contribute to C-OCD.-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofPsychophysiology-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectconcept-
dc.subjectcontamination-
dc.subjectdisgust-
dc.subjectobsessive-compulsive disorder-
dc.subjectPavlovian conditioning-
dc.titleConceptual-level disgust conditioning in contamination-based obsessive-compulsive disorder-
dc.typeArticle-
dc.identifier.doi10.1111/psyp.14637-
dc.identifier.scopuseid_2-s2.0-85197292592-
dc.identifier.eissn1469-8986-
dc.identifier.issnl0048-5772-

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