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Article: Unfolding the Complexity of Exosome–Cellular Interactions on Tumour Immunity and Their Clinical Prospects in Nasopharyngeal Carcinoma
Title | Unfolding the Complexity of Exosome–Cellular Interactions on Tumour Immunity and Their Clinical Prospects in Nasopharyngeal Carcinoma |
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Authors | |
Keywords | biomarkers cancer vaccine cellular therapy exosomes extracellular vesicles immune checkpoint inhibitors liquid biopsy nasopharyngeal carcinoma tumour microenvironment |
Issue Date | 24-Feb-2024 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Citation | Cancers, 2024, v. 16, n. 5 How to Cite? |
Abstract | Nasopharyngeal carcinoma (NPC) is an epithelial malignancy situated in the posterolateral nasopharynx. NPC poses grave concerns in Southeast Asia due to its late diagnosis. Together with resistance to standard treatment combining chemo- and radiotherapy, NPC presents high metastatic rates and common recurrence. Despite advancements in immune-checkpoint inhibitors (ICIs) and cytotoxic-T-lymphocytes (CTLs)-based cellular therapy, the exhaustive T cell profile and other signs of immunosuppression within the NPC tumour microenvironment (TME) remain as concerns to immunotherapy response. Exosomes, extracellular vesicles of 30–150 nm in diameter, are increasingly studied and linked to tumourigenesis in oncology. These bilipid-membrane-bound vesicles are packaged with a variety of signalling molecules, mediating cell–cell communications. Within the TME, exosomes can originate from tumour, immune, or stromal cells. Although there are studies on tumour-derived exosomes (TEX) in NPC and their effects on tumour processes like angiogenesis, metastasis, therapeutic resistance, there is a lack of research on their involvement in immune evasion. In this review, we aim to enhance the comprehension of how NPC TEX contribute to cellular immunosuppression. Furthermore, considering the detectability of TEX in bodily fluids, we will also discuss the potential development of TEX-related biomarkers for liquid biopsy in NPC as this could facilitate early diagnosis and prognostication of the disease. |
Persistent Identifier | http://hdl.handle.net/10722/346050 |
ISSN | 2023 Impact Factor: 4.5 2023 SCImago Journal Rankings: 1.391 |
DC Field | Value | Language |
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dc.contributor.author | Chak, Paak Ting | - |
dc.contributor.author | Kam, Ngar Woon | - |
dc.contributor.author | Choi, Tsz Ho | - |
dc.contributor.author | Dai, Wei | - |
dc.contributor.author | Kwong, Dora Lai Wan | - |
dc.date.accessioned | 2024-09-07T00:30:19Z | - |
dc.date.available | 2024-09-07T00:30:19Z | - |
dc.date.issued | 2024-02-24 | - |
dc.identifier.citation | Cancers, 2024, v. 16, n. 5 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/10722/346050 | - |
dc.description.abstract | <p>Nasopharyngeal carcinoma (NPC) is an epithelial malignancy situated in the posterolateral nasopharynx. NPC poses grave concerns in Southeast Asia due to its late diagnosis. Together with resistance to standard treatment combining chemo- and radiotherapy, NPC presents high metastatic rates and common recurrence. Despite advancements in immune-checkpoint inhibitors (ICIs) and cytotoxic-T-lymphocytes (CTLs)-based cellular therapy, the exhaustive T cell profile and other signs of immunosuppression within the NPC tumour microenvironment (TME) remain as concerns to immunotherapy response. Exosomes, extracellular vesicles of 30–150 nm in diameter, are increasingly studied and linked to tumourigenesis in oncology. These bilipid-membrane-bound vesicles are packaged with a variety of signalling molecules, mediating cell–cell communications. Within the TME, exosomes can originate from tumour, immune, or stromal cells. Although there are studies on tumour-derived exosomes (TEX) in NPC and their effects on tumour processes like angiogenesis, metastasis, therapeutic resistance, there is a lack of research on their involvement in immune evasion. In this review, we aim to enhance the comprehension of how NPC TEX contribute to cellular immunosuppression. Furthermore, considering the detectability of TEX in bodily fluids, we will also discuss the potential development of TEX-related biomarkers for liquid biopsy in NPC as this could facilitate early diagnosis and prognostication of the disease.</p> | - |
dc.language | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.ispartof | Cancers | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | biomarkers | - |
dc.subject | cancer vaccine | - |
dc.subject | cellular therapy | - |
dc.subject | exosomes | - |
dc.subject | extracellular vesicles | - |
dc.subject | immune checkpoint inhibitors | - |
dc.subject | liquid biopsy | - |
dc.subject | nasopharyngeal carcinoma | - |
dc.subject | tumour microenvironment | - |
dc.title | Unfolding the Complexity of Exosome–Cellular Interactions on Tumour Immunity and Their Clinical Prospects in Nasopharyngeal Carcinoma | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.3390/cancers16050919 | - |
dc.identifier.scopus | eid_2-s2.0-85187647811 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 5 | - |
dc.identifier.issnl | 2072-6694 | - |