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Article: Predictive Factors of Cloxacillin Susceptibility in Primary Bacterial Spinal Infection
Title | Predictive Factors of Cloxacillin Susceptibility in Primary Bacterial Spinal Infection |
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Authors | |
Keywords | infection spine spondylodiscitis |
Issue Date | 6-May-2024 |
Publisher | SAGE Publications |
Citation | Global Spine Journal, 2024 How to Cite? |
Abstract | Study Design: Prognostic study. Objectives: The objective of this study is to identify predictive factors for cloxacillin susceptibility in spinal infections. Methods: A retrospective analysis was conducted using data from January 1, 1997, to December 31, 2021. The study included patients presenting with back pain and either a positive bacterial culture from the spine or radiological evidence of spinal infection (spondylodiscitis and/or epidural abscess) along with positive bacterial blood culture. Results: Among 171 patients (127 males, 44 females), 53.2% had Staphylococcus isolates, with 40.4% showing cloxacillin resistance. Lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, and residence in an old age home predicted gram-positive bacteria with cloxacillin resistance and gram-negative bacteria as causative organisms (P<.05). The 30-day and 1-year all-cause mortality rates were 0% and 8.2%, respectively. Higher red cell distribution width (RDW >16.1%) and Charlson comorbidity index (CCI) scores predicted 1-year all-cause mortality (P<.05). Intensive care unit admission was required for 9.9% of patients. Conclusions: This study identified predictive factors for spinal infection by gram-positive bacteria with cloxacillin resistance and gram-negative bacteria. Patients with lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, or residency in an old age home upon admission should avoid standalone cloxacillin therapy and consider antibiotics with gram-negative coverage. Higher RDW (>16.1%) and CCI scores were associated with increased 1-year all-cause mortality. These findings contribute to treatment decision-making and improving patient outcomes in spinal infections. |
Persistent Identifier | http://hdl.handle.net/10722/345981 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 1.264 |
DC Field | Value | Language |
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dc.contributor.author | Tang, Chris Yuk Kwan | - |
dc.contributor.author | Ho, Pak Leung | - |
dc.date.accessioned | 2024-09-05T00:30:15Z | - |
dc.date.available | 2024-09-05T00:30:15Z | - |
dc.date.issued | 2024-05-06 | - |
dc.identifier.citation | Global Spine Journal, 2024 | - |
dc.identifier.issn | 2192-5682 | - |
dc.identifier.uri | http://hdl.handle.net/10722/345981 | - |
dc.description.abstract | Study Design: Prognostic study. Objectives: The objective of this study is to identify predictive factors for cloxacillin susceptibility in spinal infections. Methods: A retrospective analysis was conducted using data from January 1, 1997, to December 31, 2021. The study included patients presenting with back pain and either a positive bacterial culture from the spine or radiological evidence of spinal infection (spondylodiscitis and/or epidural abscess) along with positive bacterial blood culture. Results: Among 171 patients (127 males, 44 females), 53.2% had Staphylococcus isolates, with 40.4% showing cloxacillin resistance. Lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, and residence in an old age home predicted gram-positive bacteria with cloxacillin resistance and gram-negative bacteria as causative organisms (P<.05). The 30-day and 1-year all-cause mortality rates were 0% and 8.2%, respectively. Higher red cell distribution width (RDW >16.1%) and Charlson comorbidity index (CCI) scores predicted 1-year all-cause mortality (P<.05). Intensive care unit admission was required for 9.9% of patients. Conclusions: This study identified predictive factors for spinal infection by gram-positive bacteria with cloxacillin resistance and gram-negative bacteria. Patients with lower globulin levels (<33.5 g/L), recent hospitalization within 90 days, or residency in an old age home upon admission should avoid standalone cloxacillin therapy and consider antibiotics with gram-negative coverage. Higher RDW (>16.1%) and CCI scores were associated with increased 1-year all-cause mortality. These findings contribute to treatment decision-making and improving patient outcomes in spinal infections. | - |
dc.language | eng | - |
dc.publisher | SAGE Publications | - |
dc.relation.ispartof | Global Spine Journal | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | infection | - |
dc.subject | spine | - |
dc.subject | spondylodiscitis | - |
dc.title | Predictive Factors of Cloxacillin Susceptibility in Primary Bacterial Spinal Infection | - |
dc.type | Article | - |
dc.identifier.doi | 10.1177/21925682241251814 | - |
dc.identifier.scopus | eid_2-s2.0-85192346797 | - |
dc.identifier.eissn | 2192-5690 | - |
dc.identifier.issnl | 2192-5682 | - |