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- Publisher Website: 10.1021/acsnano.3c12163
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Article: Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction
Title | Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction |
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Authors | |
Keywords | intervertebral disc degeneration metal-phenolic nanoparticles mitochondrial dysfunction mitochondrial target reactive oxygen species scavenging |
Issue Date | 11-Mar-2024 |
Publisher | American Chemical Society |
Citation | ACS Nano, 2024, v. 18, n. 12, p. 8885-8905 How to Cite? |
Abstract | As intervertebral disc degeneration (IVDD) proceeds, the dysfunctional mitochondria disrupt the viability of nucleus pulposus cells, initiating the degradation of the extracellular matrix. To date, there is a lack of effective therapies targeting the mitochondria of nucleus pulposus cells. Here, we synthesized polygallic acid-manganese (PGA-Mn) nanoparticles via self-assembly polymerization of gallic acid in an aqueous medium and introduced a mitochondrial targeting peptide (TP04) onto the nanoparticles using a Schiff base linkage, resulting in PGA-Mn-TP04 nanoparticles. With a size smaller than 50 nm, PGA-Mn-TP04 possesses pH-buffering capacity, avoiding lysosomal confinement and selectively accumulating within mitochondria through electrostatic interactions. The rapid electron exchange between manganese ions and gallic acid enhances the redox capability of PGA-Mn-TP04, effectively reducing mitochondrial damage caused by mitochondrial reactive oxygen species. Moreover, PGA-Mn-TP04 restores mitochondrial function by facilitating the fusion of mitochondria and minimizing their fission, thereby sustaining the vitality of nucleus pulposus cells. In the rat IVDD model, PGA-Mn-TP04 maintained intervertebral disc height and nucleus pulposus tissue hydration. It offers a nonoperative treatment approach for IVDD and other skeletal muscle diseases resulting from mitochondrial dysfunction, presenting an alternative to traditional surgical interventions. |
Persistent Identifier | http://hdl.handle.net/10722/345884 |
ISSN | 2023 Impact Factor: 15.8 2023 SCImago Journal Rankings: 4.593 |
DC Field | Value | Language |
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dc.contributor.author | Chen, Qizhu | - |
dc.contributor.author | Qian, Qiuping | - |
dc.contributor.author | Xu, Hongbo | - |
dc.contributor.author | Zhou, Hao | - |
dc.contributor.author | Chen, Linjie | - |
dc.contributor.author | Shao, Nannan | - |
dc.contributor.author | Zhang, Kai | - |
dc.contributor.author | Chen, Tao | - |
dc.contributor.author | Tian, Haijun | - |
dc.contributor.author | Zhang, Zhiguang | - |
dc.contributor.author | Jones, Morgan | - |
dc.contributor.author | Kwan, Kenny Yat Hong | - |
dc.contributor.author | Sewell, Mathew | - |
dc.contributor.author | Shen, Shuying | - |
dc.contributor.author | Wang, Xiangyang | - |
dc.contributor.author | Khan, Moonis Ali | - |
dc.contributor.author | Makvandi, Pooyan | - |
dc.contributor.author | Jin, Shengwei | - |
dc.contributor.author | Zhou, Yunlong | - |
dc.contributor.author | Wu, Aimin | - |
dc.date.accessioned | 2024-09-04T07:06:14Z | - |
dc.date.available | 2024-09-04T07:06:14Z | - |
dc.date.issued | 2024-03-11 | - |
dc.identifier.citation | ACS Nano, 2024, v. 18, n. 12, p. 8885-8905 | - |
dc.identifier.issn | 1936-0851 | - |
dc.identifier.uri | http://hdl.handle.net/10722/345884 | - |
dc.description.abstract | As intervertebral disc degeneration (IVDD) proceeds, the dysfunctional mitochondria disrupt the viability of nucleus pulposus cells, initiating the degradation of the extracellular matrix. To date, there is a lack of effective therapies targeting the mitochondria of nucleus pulposus cells. Here, we synthesized polygallic acid-manganese (PGA-Mn) nanoparticles via self-assembly polymerization of gallic acid in an aqueous medium and introduced a mitochondrial targeting peptide (TP04) onto the nanoparticles using a Schiff base linkage, resulting in PGA-Mn-TP04 nanoparticles. With a size smaller than 50 nm, PGA-Mn-TP04 possesses pH-buffering capacity, avoiding lysosomal confinement and selectively accumulating within mitochondria through electrostatic interactions. The rapid electron exchange between manganese ions and gallic acid enhances the redox capability of PGA-Mn-TP04, effectively reducing mitochondrial damage caused by mitochondrial reactive oxygen species. Moreover, PGA-Mn-TP04 restores mitochondrial function by facilitating the fusion of mitochondria and minimizing their fission, thereby sustaining the vitality of nucleus pulposus cells. In the rat IVDD model, PGA-Mn-TP04 maintained intervertebral disc height and nucleus pulposus tissue hydration. It offers a nonoperative treatment approach for IVDD and other skeletal muscle diseases resulting from mitochondrial dysfunction, presenting an alternative to traditional surgical interventions. | - |
dc.language | eng | - |
dc.publisher | American Chemical Society | - |
dc.relation.ispartof | ACS Nano | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | intervertebral disc degeneration | - |
dc.subject | metal-phenolic nanoparticles | - |
dc.subject | mitochondrial dysfunction | - |
dc.subject | mitochondrial target | - |
dc.subject | reactive oxygen species scavenging | - |
dc.title | Mitochondrial-Targeted Metal-Phenolic Nanoparticles to Attenuate Intervertebral Disc Degeneration: Alleviating Oxidative Stress and Mitochondrial Dysfunction | - |
dc.type | Article | - |
dc.identifier.doi | 10.1021/acsnano.3c12163 | - |
dc.identifier.scopus | eid_2-s2.0-85187564914 | - |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 8885 | - |
dc.identifier.epage | 8905 | - |
dc.identifier.eissn | 1936-086X | - |
dc.identifier.issnl | 1936-0851 | - |