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Article: The modulation effect of cognition on mentalization in late-life depression: a study of gaze perception—a potential screening tool for high-risk group of late-life depression

TitleThe modulation effect of cognition on mentalization in late-life depression: a study of gaze perception—a potential screening tool for high-risk group of late-life depression
Authors
Keywordsearly detection
gaze perception
late-life depression
mentalisation
social cognition
Issue Date1-May-2024
PublisherFrontiers Media
Citation
Frontiers in Psychiatry, 2024, v. 15 How to Cite?
Abstract

Introduction: Impairment in mentalization is implicated in the development and maintenance of depression. Major depressive disorders showed significant impairment in social cognition and such impairment appears to be positively associated with the severity of depression. Self-referential gaze perception (SRGP), a measurement of mentalization, was predominantly measured in patients with psychosis but rarely examined in late-life depression (LLD). Methods: To assess the effect of cognition on the interpretation bias of mentalization, 29 LLD patients and 29 healthy controls were asked to judge if various gaze directions were directed to self in SRGP. Results: Patients with better cognition showed less unambiguous-SRGP bias than those with worse cognitive scores; this difference was not found in healthy controls. Global cognition and executive function contributed to the SRGP rate in patients. Conclusion: The current study is the first study to explore the relationship between cognition and SRGP in the LLD population. Our study findings suggested that the cognitive function of LLD patients may contribute to the modulation of interpretation bias, which in turn underlie the role of SRGP bias. Greater SRGP bias in patients may reflect social cognition deterioration, impairing the social interaction and functioning of LLD patients. This highlights the need for early intervention and cognitive decline identification to facilitate better prognosis and treatment effectiveness; thus, further studies could navigate the potential of SRGP task as a screening tool for high-risk group of LLD likely to develop dementia.


Persistent Identifierhttp://hdl.handle.net/10722/345657

 

DC FieldValueLanguage
dc.contributor.authorNgan, Sze Ting Joanna-
dc.contributor.authorCheng, Calvin Pak Wing-
dc.contributor.authorChan, Wai Chi-
dc.contributor.authorTsui, Kam Hung Harry-
dc.contributor.authorWong, Sau Man Corine-
dc.contributor.authorChan, Kit Wa Sherry-
dc.date.accessioned2024-08-27T09:10:18Z-
dc.date.available2024-08-27T09:10:18Z-
dc.date.issued2024-05-01-
dc.identifier.citationFrontiers in Psychiatry, 2024, v. 15-
dc.identifier.urihttp://hdl.handle.net/10722/345657-
dc.description.abstract<p>Introduction: Impairment in mentalization is implicated in the development and maintenance of depression. Major depressive disorders showed significant impairment in social cognition and such impairment appears to be positively associated with the severity of depression. Self-referential gaze perception (SRGP), a measurement of mentalization, was predominantly measured in patients with psychosis but rarely examined in late-life depression (LLD). Methods: To assess the effect of cognition on the interpretation bias of mentalization, 29 LLD patients and 29 healthy controls were asked to judge if various gaze directions were directed to self in SRGP. Results: Patients with better cognition showed less unambiguous-SRGP bias than those with worse cognitive scores; this difference was not found in healthy controls. Global cognition and executive function contributed to the SRGP rate in patients. Conclusion: The current study is the first study to explore the relationship between cognition and SRGP in the LLD population. Our study findings suggested that the cognitive function of LLD patients may contribute to the modulation of interpretation bias, which in turn underlie the role of SRGP bias. Greater SRGP bias in patients may reflect social cognition deterioration, impairing the social interaction and functioning of LLD patients. This highlights the need for early intervention and cognitive decline identification to facilitate better prognosis and treatment effectiveness; thus, further studies could navigate the potential of SRGP task as a screening tool for high-risk group of LLD likely to develop dementia.</p>-
dc.languageeng-
dc.publisherFrontiers Media-
dc.relation.ispartofFrontiers in Psychiatry-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectearly detection-
dc.subjectgaze perception-
dc.subjectlate-life depression-
dc.subjectmentalisation-
dc.subjectsocial cognition-
dc.titleThe modulation effect of cognition on mentalization in late-life depression: a study of gaze perception—a potential screening tool for high-risk group of late-life depression-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.3389/fpsyt.2024.1199119-
dc.identifier.scopuseid_2-s2.0-85193068437-
dc.identifier.volume15-
dc.identifier.eissn1664-0640-
dc.identifier.issnl1664-0640-

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