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Article: Rare-variant association study unveils the Achilles’ heel for HCC
| Title | Rare-variant association study unveils the Achilles’ heel for HCC |
|---|---|
| Authors | |
| Issue Date | 8-May-2024 |
| Publisher | Cell Press |
| Citation | Cell Genomics, 2024, v. 4, n. 5 How to Cite? |
| Abstract | In this issue of Cell Genomics, Wang, Liu, Zuo, Wang, et al.1 investigate rare variants in hepatocellular carcinoma (HCC) by performing the first rare-variant association study (RVAS) in a Chinese population cohort. It uncovers BRCAness phenotypes associated with the NRDE2-p.N377I variant, suggesting PARP inhibitors as a promising therapeutic approach for certain HCC patients. |
| Persistent Identifier | http://hdl.handle.net/10722/345654 |
| ISSN | 2023 Impact Factor: 11.1 2023 SCImago Journal Rankings: 8.807 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Wang, Yin | - |
| dc.contributor.author | Chan, Ying Wai | - |
| dc.date.accessioned | 2024-08-27T09:10:17Z | - |
| dc.date.available | 2024-08-27T09:10:17Z | - |
| dc.date.issued | 2024-05-08 | - |
| dc.identifier.citation | Cell Genomics, 2024, v. 4, n. 5 | - |
| dc.identifier.issn | 2666-979X | - |
| dc.identifier.uri | http://hdl.handle.net/10722/345654 | - |
| dc.description.abstract | In this issue of Cell Genomics, Wang, Liu, Zuo, Wang, et al.1 investigate rare variants in hepatocellular carcinoma (HCC) by performing the first rare-variant association study (RVAS) in a Chinese population cohort. It uncovers BRCAness phenotypes associated with the NRDE2-p.N377I variant, suggesting PARP inhibitors as a promising therapeutic approach for certain HCC patients. | - |
| dc.language | eng | - |
| dc.publisher | Cell Press | - |
| dc.relation.ispartof | Cell Genomics | - |
| dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
| dc.title | Rare-variant association study unveils the Achilles’ heel for HCC | - |
| dc.type | Article | - |
| dc.description.nature | published_or_final_version | - |
| dc.identifier.doi | 10.1016/j.xgen.2024.100558 | - |
| dc.identifier.scopus | eid_2-s2.0-85192109982 | - |
| dc.identifier.volume | 4 | - |
| dc.identifier.issue | 5 | - |
| dc.identifier.eissn | 2666-979X | - |
| dc.identifier.issnl | 2666-979X | - |