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Article: Comprehensive assessment of immune context and immunotherapy response via noninvasive imaging in gastric cancer

TitleComprehensive assessment of immune context and immunotherapy response via noninvasive imaging in gastric cancer
Authors
Issue Date15-Mar-2024
PublisherAmerican Society for Clinical Investigation
Citation
The Journal of Clinical Investigation, 2024, v. 134, n. 6 How to Cite?
Abstract

BACKGROUND. The tumor immune microenvironment can provide prognostic and therapeutic information. We aimed to develop noninvasive imaging biomarkers from computed tomography (CT) for comprehensive evaluation of immune context and investigate their associations with prognosis and immunotherapy response in gastric cancer (GC). METHODS. This study involved 2,600 patients with GC from 9 independent cohorts. We developed and validated 2 CT imaging biomarkers (lymphoid radiomics score [LRS] and myeloid radiomics score [MRS]) for evaluating the IHC-derived lymphoid and myeloid immune context respectively, and integrated them into a combined imaging biomarker [LRS/MRS: low(−) or high(+)] with 4 radiomics immune subtypes: 1 (−/−), 2 (+/−), 3 (−/+), and 4 (+/+). We further evaluated the imaging biomarkers’ predictive values on prognosis and immunotherapy response. RESULTS. The developed imaging biomarkers (LRS and MRS) had a high accuracy in predicting lymphoid (AUC range: 0.765–0.773) and myeloid (AUC range: 0.736–0.750) immune context. Further, similar to the IHC-derived immune context, 2 imaging biomarkers (HR range: 0.240–0.761 for LRS; 1.301–4.012 for MRS) and the combined biomarker were independent predictors for disease-free and overall survival in the training and all validation cohorts (all P < 0.05). Additionally, patients with high LRS or low MRS may benefit more from immunotherapy (P < 0.001). Further, a highly heterogeneous outcome on objective response rate was observed in 4 imaging subtypes: 1 (−/−) with 27.3%, 2 (+/−) with 53.3%, 3 (−/+) with 10.2%, and 4 (+/+) with 30.0% (P < 0.0001). CONCLUSION. The noninvasive imaging biomarkers could accurately evaluate the immune context and provide information regarding prognosis and immunotherapy for GC.


Persistent Identifierhttp://hdl.handle.net/10722/345631
ISSN
2023 Impact Factor: 13.3
2023 SCImago Journal Rankings: 4.833

 

DC FieldValueLanguage
dc.contributor.authorSun, Zepang-
dc.contributor.authorZhang, Taojun-
dc.contributor.authorAhmad, M. Usman-
dc.contributor.authorZhou, Zixia-
dc.contributor.authorQiu, Liang-
dc.contributor.authorZhou, Kangneng-
dc.contributor.authorXiong, Wenjun-
dc.contributor.authorXie, Jingjing-
dc.contributor.authorZhang, Zhicheng-
dc.contributor.authorChen, Chuanli-
dc.contributor.authorYuan, Qingyu-
dc.contributor.authorChen, Yan-
dc.contributor.authorFeng, Wanying-
dc.contributor.authorXu, Yikai-
dc.contributor.authorYu, Lequan-
dc.contributor.authorWang, Wei-
dc.contributor.authorYu, Jiang-
dc.contributor.authorLi, Guoxin-
dc.contributor.authorJiang, Yuming-
dc.date.accessioned2024-08-27T09:10:07Z-
dc.date.available2024-08-27T09:10:07Z-
dc.date.issued2024-03-15-
dc.identifier.citationThe Journal of Clinical Investigation, 2024, v. 134, n. 6-
dc.identifier.issn0021-9738-
dc.identifier.urihttp://hdl.handle.net/10722/345631-
dc.description.abstract<p>BACKGROUND. The tumor immune microenvironment can provide prognostic and therapeutic information. We aimed to develop noninvasive imaging biomarkers from computed tomography (CT) for comprehensive evaluation of immune context and investigate their associations with prognosis and immunotherapy response in gastric cancer (GC). METHODS. This study involved 2,600 patients with GC from 9 independent cohorts. We developed and validated 2 CT imaging biomarkers (lymphoid radiomics score [LRS] and myeloid radiomics score [MRS]) for evaluating the IHC-derived lymphoid and myeloid immune context respectively, and integrated them into a combined imaging biomarker [LRS/MRS: low(−) or high(+)] with 4 radiomics immune subtypes: 1 (−/−), 2 (+/−), 3 (−/+), and 4 (+/+). We further evaluated the imaging biomarkers’ predictive values on prognosis and immunotherapy response. RESULTS. The developed imaging biomarkers (LRS and MRS) had a high accuracy in predicting lymphoid (AUC range: 0.765–0.773) and myeloid (AUC range: 0.736–0.750) immune context. Further, similar to the IHC-derived immune context, 2 imaging biomarkers (HR range: 0.240–0.761 for LRS; 1.301–4.012 for MRS) and the combined biomarker were independent predictors for disease-free and overall survival in the training and all validation cohorts (all P < 0.05). Additionally, patients with high LRS or low MRS may benefit more from immunotherapy (P < 0.001). Further, a highly heterogeneous outcome on objective response rate was observed in 4 imaging subtypes: 1 (−/−) with 27.3%, 2 (+/−) with 53.3%, 3 (−/+) with 10.2%, and 4 (+/+) with 30.0% (P < 0.0001). CONCLUSION. The noninvasive imaging biomarkers could accurately evaluate the immune context and provide information regarding prognosis and immunotherapy for GC.</p>-
dc.languageeng-
dc.publisherAmerican Society for Clinical Investigation-
dc.relation.ispartofThe Journal of Clinical Investigation-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titleComprehensive assessment of immune context and immunotherapy response via noninvasive imaging in gastric cancer-
dc.typeArticle-
dc.identifier.doi10.1172/JCI175834-
dc.identifier.pmid38271117-
dc.identifier.scopuseid_2-s2.0-85187956437-
dc.identifier.volume134-
dc.identifier.issue6-
dc.identifier.eissn1558-8238-
dc.identifier.issnl0021-9738-

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