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Article: Caries Management with Non-Metallic Nanomaterials: A Systematic Review
Title | Caries Management with Non-Metallic Nanomaterials: A Systematic Review |
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Authors | |
Keywords | antibacterial caries nanomaterials nanoparticles prevention remineralisation |
Issue Date | 30-Nov-2022 |
Publisher | Taylor and Francis Group |
Citation | International Journal of Nanomedicine, 2022, v. 17, p. 5809-5824 How to Cite? |
Abstract | Background: Non-metallic nanomaterials do not stain enamel or dentin. Most have better biocompatibility than metallic nanomater-ials do for management of dental caries. Objective: The objective of this study is to review the types, properties and potential uses of non-metallic nanomaterials system-atically for managing dental caries. Methods: Two researchers independently performed a literature search of publications in English using PubMed, Scopus and Web of Science. The keywords used were (nanoparticles OR nanocomposites OR nanomaterials) AND (caries OR tooth decay). They screened the titles and abstracts to identify potentially eligible publications of original research reporting non-metallic nanomaterials for caries management. Then, they retrieved and studied the full text of the identified publications for inclusion in this study. Results: Out of 2497 resulting publications, this study included 75 of those. The non-metallic nanomaterials used in these publications were categorized as biological organic nanomaterials (n=45), synthetic organic nanomaterials (n=15), carbon-based nanomaterials (n=13) and selenium nanomaterials (n=2). They inhibited bacteria growth and/or promoted remineralization. They could be incorporated in topical agents (29/75, 39%), dental adhesives (11/75, 15%), restorative fillers (4/75, 5%), dental sealant (3/75, 4%), oral drugs (3/75, 4%), toothpastes (2/75, 3%) and functional candies (1/75, 1%). Other publications (22/75, 29%) do not mention specific applications. However, most publications (67/75, 89%) were in vitro studies. Six publications (6/75, 8%) were animal studies, and only two publications (2/75, 3%) were clinical studies. Conclusion: The literature showed non-metallic nanomaterials have antibacterial and/or remineralising properties. The most common type of non-metallic nanomaterials for caries management is organic nanomaterials. Non-metallic nanomaterials can be incorporated into dental sealants, toothpaste, dental adhesives, topical agents and even candies and drugs. However, the majority of the publications are in vitro studies, and only two publications are clinical studies. |
Persistent Identifier | http://hdl.handle.net/10722/345505 |
ISSN | 2010 Impact Factor: 4.976 2023 SCImago Journal Rankings: 1.273 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Xu, Veena Wenqing | - |
dc.contributor.author | Nizami, Mohammed Zahedul Islam | - |
dc.contributor.author | Yin, Iris Xiaoxue | - |
dc.contributor.author | Lung, Christie Ying Kei | - |
dc.contributor.author | Yu, Ollie Yiru | - |
dc.contributor.author | Chu, Chun Hung | - |
dc.date.accessioned | 2024-08-27T09:09:11Z | - |
dc.date.available | 2024-08-27T09:09:11Z | - |
dc.date.issued | 2022-11-30 | - |
dc.identifier.citation | International Journal of Nanomedicine, 2022, v. 17, p. 5809-5824 | - |
dc.identifier.issn | 1176-9114 | - |
dc.identifier.uri | http://hdl.handle.net/10722/345505 | - |
dc.description.abstract | Background: Non-metallic nanomaterials do not stain enamel or dentin. Most have better biocompatibility than metallic nanomater-ials do for management of dental caries. Objective: The objective of this study is to review the types, properties and potential uses of non-metallic nanomaterials system-atically for managing dental caries. Methods: Two researchers independently performed a literature search of publications in English using PubMed, Scopus and Web of Science. The keywords used were (nanoparticles OR nanocomposites OR nanomaterials) AND (caries OR tooth decay). They screened the titles and abstracts to identify potentially eligible publications of original research reporting non-metallic nanomaterials for caries management. Then, they retrieved and studied the full text of the identified publications for inclusion in this study. Results: Out of 2497 resulting publications, this study included 75 of those. The non-metallic nanomaterials used in these publications were categorized as biological organic nanomaterials (n=45), synthetic organic nanomaterials (n=15), carbon-based nanomaterials (n=13) and selenium nanomaterials (n=2). They inhibited bacteria growth and/or promoted remineralization. They could be incorporated in topical agents (29/75, 39%), dental adhesives (11/75, 15%), restorative fillers (4/75, 5%), dental sealant (3/75, 4%), oral drugs (3/75, 4%), toothpastes (2/75, 3%) and functional candies (1/75, 1%). Other publications (22/75, 29%) do not mention specific applications. However, most publications (67/75, 89%) were in vitro studies. Six publications (6/75, 8%) were animal studies, and only two publications (2/75, 3%) were clinical studies. Conclusion: The literature showed non-metallic nanomaterials have antibacterial and/or remineralising properties. The most common type of non-metallic nanomaterials for caries management is organic nanomaterials. Non-metallic nanomaterials can be incorporated into dental sealants, toothpaste, dental adhesives, topical agents and even candies and drugs. However, the majority of the publications are in vitro studies, and only two publications are clinical studies. | - |
dc.language | eng | - |
dc.publisher | Taylor and Francis Group | - |
dc.relation.ispartof | International Journal of Nanomedicine | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | antibacterial | - |
dc.subject | caries | - |
dc.subject | nanomaterials | - |
dc.subject | nanoparticles | - |
dc.subject | prevention | - |
dc.subject | remineralisation | - |
dc.title | Caries Management with Non-Metallic Nanomaterials: A Systematic Review | - |
dc.type | Article | - |
dc.description.nature | published_or_final_version | - |
dc.identifier.doi | 10.2147/IJN.S389038 | - |
dc.identifier.pmid | 36474525 | - |
dc.identifier.scopus | eid_2-s2.0-85143557870 | - |
dc.identifier.volume | 17 | - |
dc.identifier.spage | 5809 | - |
dc.identifier.epage | 5824 | - |
dc.identifier.eissn | 1178-2013 | - |
dc.identifier.isi | WOS:001125652100001 | - |
dc.identifier.issnl | 1176-9114 | - |