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- Publisher Website: 10.1126/sciadv.adg3469
- Scopus: eid_2-s2.0-85170347644
- PMID: 37683004
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Article: Single-cycle influenza virus vaccine generates lung CD8+ Trm that cross-react against viral variants and subvert virus escape mutants
Title | Single-cycle influenza virus vaccine generates lung CD8<sup>+</sup> Trm that cross-react against viral variants and subvert virus escape mutants |
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Authors | |
Issue Date | 2023 |
Citation | Science Advances, 2023, v. 9, n. 36, article no. eadg3469 eadg3469 How to Cite? |
Abstract | Influenza virus–specific tissue-resident memory (Trm) CD8+ T cells located along the respiratory tract provide cross-strain protection against a breadth of influenza viruses. We show that immunization with a single-cycle influenza virus vaccine candidate (S-FLU) results in the deposition of influenza virus nucleoprotein (NP)–specific CD8+ Trm along the respiratory tract that were more cross-reactive against viral variants and less likely to drive the development of cytotoxic T lymphocyte (CTL) escape mutants, as compared to the lung memory NP-specific CD8+ T cell pool established following influenza infection. This immune profile was linked to the limited inflammatory response evoked by S-FLU vaccination, which increased TCR repertoire diversity within the memory CD8+ T cell compartment. Cumulatively, this work shows that S-FLU vaccination evokes a clonally diverse, cross-reactive memory CD8+ T cell pool, which protects against severe disease without driving the virus to rapidly evolve and escape, and thus represents an attractive vaccine for use against rapidly mutating influenza viruses. |
Persistent Identifier | http://hdl.handle.net/10722/345351 |
DC Field | Value | Language |
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dc.contributor.author | Zheng, Ming Z.M. | - |
dc.contributor.author | Tan, Tiong Kit | - |
dc.contributor.author | Villalon-Letelier, Fernando | - |
dc.contributor.author | Lau, Hilda | - |
dc.contributor.author | Deng, Yi Mo | - |
dc.contributor.author | Fritzlar, Svenja | - |
dc.contributor.author | Valkenburg, Sophie A. | - |
dc.contributor.author | Gu, Haogao | - |
dc.contributor.author | Poon, Leo L.M. | - |
dc.contributor.author | Reading, Patrick C. | - |
dc.contributor.author | Townsend, Alain R. | - |
dc.contributor.author | Wakim, Linda M. | - |
dc.date.accessioned | 2024-08-15T09:26:48Z | - |
dc.date.available | 2024-08-15T09:26:48Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | Science Advances, 2023, v. 9, n. 36, article no. eadg3469 eadg3469 | - |
dc.identifier.uri | http://hdl.handle.net/10722/345351 | - |
dc.description.abstract | Influenza virus–specific tissue-resident memory (Trm) CD8+ T cells located along the respiratory tract provide cross-strain protection against a breadth of influenza viruses. We show that immunization with a single-cycle influenza virus vaccine candidate (S-FLU) results in the deposition of influenza virus nucleoprotein (NP)–specific CD8+ Trm along the respiratory tract that were more cross-reactive against viral variants and less likely to drive the development of cytotoxic T lymphocyte (CTL) escape mutants, as compared to the lung memory NP-specific CD8+ T cell pool established following influenza infection. This immune profile was linked to the limited inflammatory response evoked by S-FLU vaccination, which increased TCR repertoire diversity within the memory CD8+ T cell compartment. Cumulatively, this work shows that S-FLU vaccination evokes a clonally diverse, cross-reactive memory CD8+ T cell pool, which protects against severe disease without driving the virus to rapidly evolve and escape, and thus represents an attractive vaccine for use against rapidly mutating influenza viruses. | - |
dc.language | eng | - |
dc.relation.ispartof | Science Advances | - |
dc.title | Single-cycle influenza virus vaccine generates lung CD8<sup>+</sup> Trm that cross-react against viral variants and subvert virus escape mutants | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1126/sciadv.adg3469 | - |
dc.identifier.pmid | 37683004 | - |
dc.identifier.scopus | eid_2-s2.0-85170347644 | - |
dc.identifier.volume | 9 | - |
dc.identifier.issue | 36 | - |
dc.identifier.spage | article no. eadg3469 eadg3469 | - |
dc.identifier.epage | article no. eadg3469 eadg3469 | - |
dc.identifier.eissn | 2375-2548 | - |