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Article: Physical Activity Intensity and Risk of Dementia

TitlePhysical Activity Intensity and Risk of Dementia
Authors
Issue Date31-Jan-2024
PublisherElsevier
Citation
American Journal of Preventive Medicine, 2024, v. 66, n. 6, p. 948-956 How to Cite?
Abstract

Introduction: Regular participation in aerobic physical activity is associated with a reduced risk of dementia. It is currently unclear whether this association is due to the total volume or intensity of physical activity. Methods: This prospective cohort study analyzed 386,486 adults from the UK Biobank who were free of dementia and self-reported >0 minutes of moderate-to-vigorous intensity physical activity (MVPA) at baseline (2007–2010). Participants were categorized as performing 0%, >0%–30%, or >30% of their total MVPA in vigorous activity (VPA). Cox proportional hazards regression models were used to examine the associations between categories of VPA and incident dementia while adjusting for sociodemographic and lifestyle factors including total MVPA. Analyses were performed in 2022. Results: Over an average follow-up of 12.0 (1.7) years, there were 5,177 (1.3%) cases of dementia. Compared to the group reporting 0% VPA, the hazard ratios (95% confidence intervals) of dementia for the groups reporting >0%–30% and >30% VPA were 0.73 (0.68–0.78) and 0.81 (0.75–0.87), respectively, in the fully adjusted model. In a joint analysis, reporting some VPA was associated with a reduced risk of dementia regardless of meeting the aerobic physical activity guidelines (HR=0.78 [0.72–0.85]) or not (HR=0.76 [0.60–0.98]), while meeting the aerobic physical activity guidelines alone without VPA was not associated with incident dementia (HR=0.98 [0.90–1.07]), compared to the group that did not meet the guidelines and reported no VPA. Conclusions: These results suggest that engaging in VPA as part of MVPA is associated with a lower risk of dementia.


Persistent Identifierhttp://hdl.handle.net/10722/344962
ISSN
2023 Impact Factor: 4.3
2023 SCImago Journal Rankings: 2.044

 

DC FieldValueLanguage
dc.contributor.authorBrellenthin, Angelique G.-
dc.contributor.authorLee, Duck chul-
dc.contributor.authorLefferts, Elizabeth C.-
dc.contributor.authorLefferts, Wesley K.-
dc.contributor.authorDougherty, Ryan J.-
dc.contributor.authorKim, Youngwon-
dc.date.accessioned2024-08-14T08:56:32Z-
dc.date.available2024-08-14T08:56:32Z-
dc.date.issued2024-01-31-
dc.identifier.citationAmerican Journal of Preventive Medicine, 2024, v. 66, n. 6, p. 948-956-
dc.identifier.issn0749-3797-
dc.identifier.urihttp://hdl.handle.net/10722/344962-
dc.description.abstract<p>Introduction: Regular participation in aerobic physical activity is associated with a reduced risk of dementia. It is currently unclear whether this association is due to the total volume or intensity of physical activity. Methods: This prospective cohort study analyzed 386,486 adults from the UK Biobank who were free of dementia and self-reported >0 minutes of moderate-to-vigorous intensity physical activity (MVPA) at baseline (2007–2010). Participants were categorized as performing 0%, >0%–30%, or >30% of their total MVPA in vigorous activity (VPA). Cox proportional hazards regression models were used to examine the associations between categories of VPA and incident dementia while adjusting for sociodemographic and lifestyle factors including total MVPA. Analyses were performed in 2022. Results: Over an average follow-up of 12.0 (1.7) years, there were 5,177 (1.3%) cases of dementia. Compared to the group reporting 0% VPA, the hazard ratios (95% confidence intervals) of dementia for the groups reporting >0%–30% and >30% VPA were 0.73 (0.68–0.78) and 0.81 (0.75–0.87), respectively, in the fully adjusted model. In a joint analysis, reporting some VPA was associated with a reduced risk of dementia regardless of meeting the aerobic physical activity guidelines (HR=0.78 [0.72–0.85]) or not (HR=0.76 [0.60–0.98]), while meeting the aerobic physical activity guidelines alone without VPA was not associated with incident dementia (HR=0.98 [0.90–1.07]), compared to the group that did not meet the guidelines and reported no VPA. Conclusions: These results suggest that engaging in VPA as part of MVPA is associated with a lower risk of dementia.</p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofAmerican Journal of Preventive Medicine-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.titlePhysical Activity Intensity and Risk of Dementia-
dc.typeArticle-
dc.identifier.doi10.1016/j.amepre.2024.01.015-
dc.identifier.pmid38307157-
dc.identifier.scopuseid_2-s2.0-85185584304-
dc.identifier.volume66-
dc.identifier.issue6-
dc.identifier.spage948-
dc.identifier.epage956-
dc.identifier.eissn1873-2607-
dc.identifier.issnl0749-3797-

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