File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1007/s00787-020-01674-6
- Scopus: eid_2-s2.0-85096020841
- PMID: 33185773
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Metabolic events associated with the use of antipsychotics in children, adolescents and young adults: a multinational sequence symmetry study
Title | Metabolic events associated with the use of antipsychotics in children, adolescents and young adults: a multinational sequence symmetry study |
---|---|
Authors | |
Keywords | Antipsychotics Metabolic events Multi-national data Pediatrics Sequence symmetry analysis |
Issue Date | 1-Jan-2022 |
Publisher | Springer |
Citation | European Child & Adolescent Psychiatry, 2022, v. 31, n. 1, p. 99-120 How to Cite? |
Abstract | It is known that younger patients treated with antipsychotics are at increased risk of metabolic events; however, it is unknown how this risk varies according to ethnicity, the class of antipsychotic and the specific product used, and by age group. We conducted a multinational sequence symmetry study in Asian populations (Hong Kong, Japan, Korea, Taiwan and Thailand) and non-Asian populations (Australia and Denmark) to evaluate the metabolic events associated with antipsychotics in both Asian and non-Asian populations, for typical and atypical antipsychotics, and by the subgroups of children and adolescents, and young adults. Patients aged 6–30 years newly initiating oral antipsychotic drugs were included. We defined a composite outcome for metabolic events which included dyslipidemia, hypertension and hyperglycemia. We calculated the sequence ratio (SR) by dividing the number of people for whom a medicine for one of the outcome events was initiated within a 12-month period after antipsychotic initiation by the number before antipsychotic initiation. This study included 346,904 antipsychotic initiators across seven countries. Antipsychotic use was associated with an increased risk of composite metabolic events with a pooled adjusted SR (ASR) of 1.22 (95% CI 1.00–1.50). Pooled ASRs were similar between Asian (ASR, 1.22; 95% CI 0.88–1.70) and non-Asian populations (ASR, 1.22; 95% CI 1.04–1.43). The pooled ASR for typical and atypical antipsychotics was 0.98 (95% CI 0.85–1.12) and 1.24 (95% CI 0.97–1.59), respectively. No difference was observed in the relative effect in children and adolescents compared to young adults. The risk of metabolic events associated with antipsychotics use was similar in magnitude in Asian and non-Asian populations despite the marked difference in drug utilization patterns. |
Persistent Identifier | http://hdl.handle.net/10722/344721 |
ISSN | 2023 Impact Factor: 6.0 2023 SCImago Journal Rankings: 2.175 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Man, Kenneth K.C. | - |
dc.contributor.author | Shao, Shih Chieh | - |
dc.contributor.author | Chaiyakunapruk, Nathorn | - |
dc.contributor.author | Dilokthornsakul, Piyameth | - |
dc.contributor.author | Kubota, Kiyoshi | - |
dc.contributor.author | Li, Junqing | - |
dc.contributor.author | Ooba, Nobuhiro | - |
dc.contributor.author | Pratt, Nicole | - |
dc.contributor.author | Pottegård, Anton | - |
dc.contributor.author | Rasmussen, Lotte | - |
dc.contributor.author | Roughead, Elizabeth E. | - |
dc.contributor.author | Shin, Ju Young | - |
dc.contributor.author | Su, Chien Chou | - |
dc.contributor.author | Wong, Ian C.K. | - |
dc.contributor.author | Kao Yang, Yea Huei | - |
dc.contributor.author | Lai, Edward Chia Cheng | - |
dc.date.accessioned | 2024-08-06T08:46:25Z | - |
dc.date.available | 2024-08-06T08:46:25Z | - |
dc.date.issued | 2022-01-01 | - |
dc.identifier.citation | European Child & Adolescent Psychiatry, 2022, v. 31, n. 1, p. 99-120 | - |
dc.identifier.issn | 1018-8827 | - |
dc.identifier.uri | http://hdl.handle.net/10722/344721 | - |
dc.description.abstract | <p>It is known that younger patients treated with antipsychotics are at increased risk of metabolic events; however, it is unknown how this risk varies according to ethnicity, the class of antipsychotic and the specific product used, and by age group. We conducted a multinational sequence symmetry study in Asian populations (Hong Kong, Japan, Korea, Taiwan and Thailand) and non-Asian populations (Australia and Denmark) to evaluate the metabolic events associated with antipsychotics in both Asian and non-Asian populations, for typical and atypical antipsychotics, and by the subgroups of children and adolescents, and young adults. Patients aged 6–30 years newly initiating oral antipsychotic drugs were included. We defined a composite outcome for metabolic events which included dyslipidemia, hypertension and hyperglycemia. We calculated the sequence ratio (SR) by dividing the number of people for whom a medicine for one of the outcome events was initiated within a 12-month period after antipsychotic initiation by the number before antipsychotic initiation. This study included 346,904 antipsychotic initiators across seven countries. Antipsychotic use was associated with an increased risk of composite metabolic events with a pooled adjusted SR (ASR) of 1.22 (95% CI 1.00–1.50). Pooled ASRs were similar between Asian (ASR, 1.22; 95% CI 0.88–1.70) and non-Asian populations (ASR, 1.22; 95% CI 1.04–1.43). The pooled ASR for typical and atypical antipsychotics was 0.98 (95% CI 0.85–1.12) and 1.24 (95% CI 0.97–1.59), respectively. No difference was observed in the relative effect in children and adolescents compared to young adults. The risk of metabolic events associated with antipsychotics use was similar in magnitude in Asian and non-Asian populations despite the marked difference in drug utilization patterns.</p> | - |
dc.language | eng | - |
dc.publisher | Springer | - |
dc.relation.ispartof | European Child & Adolescent Psychiatry | - |
dc.subject | Antipsychotics | - |
dc.subject | Metabolic events | - |
dc.subject | Multi-national data | - |
dc.subject | Pediatrics | - |
dc.subject | Sequence symmetry analysis | - |
dc.title | Metabolic events associated with the use of antipsychotics in children, adolescents and young adults: a multinational sequence symmetry study | - |
dc.type | Article | - |
dc.identifier.doi | 10.1007/s00787-020-01674-6 | - |
dc.identifier.pmid | 33185773 | - |
dc.identifier.scopus | eid_2-s2.0-85096020841 | - |
dc.identifier.volume | 31 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 99 | - |
dc.identifier.epage | 120 | - |
dc.identifier.eissn | 1435-165X | - |
dc.identifier.issnl | 1018-8827 | - |