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Article: Validation of the Chinese drug hypersensitivity quality of life questionnaire: Role of delabeling

TitleValidation of the Chinese drug hypersensitivity quality of life questionnaire: Role of delabeling
Authors
KeywordsDelabeling
Drug allergy
Penicillin
Quality of life
Questionnaire
Validation
Issue Date1-Mar-2023
PublisherAsia Pacific Association of Allergy, Asthma and Clinical Immunology
Citation
Asia Pacific allergy, 2023, v. 13, n. 1, p. 3-9 How to Cite?
AbstractBackground: The Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q) is not currently available in Chinese. Besides, penicillin allergy (PA) is a worldwide public health challenge, and delabeling inauthentic PA can improve clinical and economic outcomes. However, its effect on health-related quality of life (HRQoL) remains poorly known. Objective: The study objective is to translate and validate a Chinese version of DrHy-Q and investigate the effect of PA delabeling on HRQoL using DrHy-Q. Methods: A Chinese DrHy-Q was translated then completed by patients with drug allergy labels for psychometric validation. Afterwards, another cohort of patients finished the Chinese DrHy-Q before and after their PA workup for pre-post comparison. Results: A total of 130 patients were studied. Sixty-three patients (79.4% female; median age = 59 ± 15 years) completed the Chinese DrHy-Q for validation (mean score = 38.9 ± 23.5). It demonstrated excellent internal consistency (Cronbach α = 0.956; 95% confidence interval [CI], 0.939-0.971) and test-retest reliability (intraclass correlation coefficient = 0.993 [95% CI, 0.969- 0.998]). Construct validity was confirmed by its one-dimensional structure in factor analysis. Divergent validity was established because only 2 (out of 9) SF-36 scales showed weak negative correlations to DrHy-Q. Patients with multiple implicated drugs presented significantly higher DrHy-Q scores than those with only a single drug (42.0 ± 22.5 vs 28.7 ± 24.4; P = 0.038), showing discriminant validity. Subsequently, another 67 patients (73.1% female; median age = 56 ± 15 years) underwent PA investigations and completed their pre-post DrHy-Q. A significant drop in DrHy-Q score was shown (40.8 ± 21.7 vs 26.6 ± 22.5; Cohen's d = 0.964; P < 0.001), reflecting improvement in HRQoL. Conclusion: The Chinese DrHy-Q is reliable and valid for HRQoL assessment. PA delabeling significantly benefits patients' HRQoL. Future larger-scale studies are warranted to corroborate our findings.
Persistent Identifierhttp://hdl.handle.net/10722/344346
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.516

 

DC FieldValueLanguage
dc.contributor.authorMak, Hugo W.F.-
dc.contributor.authorChan, Elsie T.S.-
dc.contributor.authorYim, Jackie S.H.-
dc.contributor.authorLee, Elaine-
dc.contributor.authorLam, Dorothy L.Y.-
dc.contributor.authorChiang, Valerie-
dc.contributor.authorLi, Philip H.-
dc.date.accessioned2024-07-24T13:50:54Z-
dc.date.available2024-07-24T13:50:54Z-
dc.date.issued2023-03-01-
dc.identifier.citationAsia Pacific allergy, 2023, v. 13, n. 1, p. 3-9-
dc.identifier.issn2233-8276-
dc.identifier.urihttp://hdl.handle.net/10722/344346-
dc.description.abstractBackground: The Drug Hypersensitivity Quality of Life Questionnaire (DrHy-Q) is not currently available in Chinese. Besides, penicillin allergy (PA) is a worldwide public health challenge, and delabeling inauthentic PA can improve clinical and economic outcomes. However, its effect on health-related quality of life (HRQoL) remains poorly known. Objective: The study objective is to translate and validate a Chinese version of DrHy-Q and investigate the effect of PA delabeling on HRQoL using DrHy-Q. Methods: A Chinese DrHy-Q was translated then completed by patients with drug allergy labels for psychometric validation. Afterwards, another cohort of patients finished the Chinese DrHy-Q before and after their PA workup for pre-post comparison. Results: A total of 130 patients were studied. Sixty-three patients (79.4% female; median age = 59 ± 15 years) completed the Chinese DrHy-Q for validation (mean score = 38.9 ± 23.5). It demonstrated excellent internal consistency (Cronbach α = 0.956; 95% confidence interval [CI], 0.939-0.971) and test-retest reliability (intraclass correlation coefficient = 0.993 [95% CI, 0.969- 0.998]). Construct validity was confirmed by its one-dimensional structure in factor analysis. Divergent validity was established because only 2 (out of 9) SF-36 scales showed weak negative correlations to DrHy-Q. Patients with multiple implicated drugs presented significantly higher DrHy-Q scores than those with only a single drug (42.0 ± 22.5 vs 28.7 ± 24.4; P = 0.038), showing discriminant validity. Subsequently, another 67 patients (73.1% female; median age = 56 ± 15 years) underwent PA investigations and completed their pre-post DrHy-Q. A significant drop in DrHy-Q score was shown (40.8 ± 21.7 vs 26.6 ± 22.5; Cohen's d = 0.964; P < 0.001), reflecting improvement in HRQoL. Conclusion: The Chinese DrHy-Q is reliable and valid for HRQoL assessment. PA delabeling significantly benefits patients' HRQoL. Future larger-scale studies are warranted to corroborate our findings.-
dc.languageeng-
dc.publisherAsia Pacific Association of Allergy, Asthma and Clinical Immunology-
dc.relation.ispartofAsia Pacific allergy-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectDelabeling-
dc.subjectDrug allergy-
dc.subjectPenicillin-
dc.subjectQuality of life-
dc.subjectQuestionnaire-
dc.subjectValidation-
dc.titleValidation of the Chinese drug hypersensitivity quality of life questionnaire: Role of delabeling-
dc.typeArticle-
dc.description.naturepublished_or_final_version-
dc.identifier.doi10.5415/apallergy.0000000000000020-
dc.identifier.scopuseid_2-s2.0-85169618806-
dc.identifier.volume13-
dc.identifier.issue1-
dc.identifier.spage3-
dc.identifier.epage9-
dc.identifier.eissn2233-8268-
dc.identifier.issnl2233-8276-

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