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- Publisher Website: 10.1016/j.tcb.2024.04.009
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Article: Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer
Title | Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer |
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Authors | |
Keywords | biomolecular condensate fusion oncoprotein Hippo signaling phase separation tumorigenesis |
Issue Date | 27-May-2024 |
Publisher | Elsevier |
Citation | Trends in Cell Biology, 2024, v. 34, n. 7, p. 566-577 How to Cite? |
Abstract | Biomolecular condensates, the membraneless cellular compartments formed by liquid–liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes. Recent studies have advanced our understanding of how these condensates formed in the cytoplasm or nucleus regulate Hippo signaling, a central player in organogenesis and tumorigenesis. Here, we review recent findings on the dynamic formation and function of biomolecular condensates in regulating the Hippo–yes-associated protein (YAP)/transcription coactivator with PDZ-binding motif (TAZ) signaling pathway under physiological and pathological processes. We further discuss how the nuclear condensates of YAP- or TAZ-fusion oncoproteins compartmentalize crucial transcriptional co-activators and alter chromatin architecture to promote oncogenic programs. Finally, we highlight key questions regarding how these findings may pave the way for novel therapeutics to target cancer. |
Persistent Identifier | http://hdl.handle.net/10722/344223 |
ISSN | 2023 Impact Factor: 13.0 2023 SCImago Journal Rankings: 6.002 |
DC Field | Value | Language |
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dc.contributor.author | Kiang, Karrie M | - |
dc.contributor.author | Ahad, Leena | - |
dc.contributor.author | Zhong, Xiaowen | - |
dc.contributor.author | Lu, Q Richard | - |
dc.date.accessioned | 2024-07-16T03:41:46Z | - |
dc.date.available | 2024-07-16T03:41:46Z | - |
dc.date.issued | 2024-05-27 | - |
dc.identifier.citation | Trends in Cell Biology, 2024, v. 34, n. 7, p. 566-577 | - |
dc.identifier.issn | 0962-8924 | - |
dc.identifier.uri | http://hdl.handle.net/10722/344223 | - |
dc.description.abstract | <p>Biomolecular condensates, the membraneless cellular compartments formed by liquid–liquid phase separation (LLPS), represent an important mechanism for physiological and tumorigenic processes. Recent studies have advanced our understanding of how these condensates formed in the cytoplasm or nucleus regulate Hippo signaling, a central player in organogenesis and tumorigenesis. Here, we review recent findings on the dynamic formation and function of biomolecular condensates in regulating the Hippo–yes-associated protein (YAP)/transcription coactivator with PDZ-binding motif (TAZ) signaling pathway under physiological and pathological processes. We further discuss how the nuclear condensates of YAP- or TAZ-fusion oncoproteins compartmentalize crucial transcriptional co-activators and alter chromatin architecture to promote oncogenic programs. Finally, we highlight key questions regarding how these findings may pave the way for novel therapeutics to target cancer.</p> | - |
dc.language | eng | - |
dc.publisher | Elsevier | - |
dc.relation.ispartof | Trends in Cell Biology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | biomolecular condensate | - |
dc.subject | fusion oncoprotein | - |
dc.subject | Hippo signaling | - |
dc.subject | phase separation | - |
dc.subject | tumorigenesis | - |
dc.title | Biomolecular condensates: hubs of Hippo-YAP/TAZ signaling in cancer | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.tcb.2024.04.009 | - |
dc.identifier.scopus | eid_2-s2.0-85194043229 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 566 | - |
dc.identifier.epage | 577 | - |
dc.identifier.eissn | 1879-3088 | - |
dc.identifier.issnl | 0962-8924 | - |