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Article: Prognostic Role of Soluble Programmed Death Ligand 1 in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis
Title | Prognostic Role of Soluble Programmed Death Ligand 1 in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis |
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Authors | |
Keywords | immune checkpoint inhibitors immunotherapy non-small cell lung cancer overall survival prognosis soluble programmed death ligand 1 |
Issue Date | 23-Dec-2021 |
Publisher | Frontiers Media |
Citation | Frontiers in Oncology, 2021, v. 11 How to Cite? |
Abstract | Objective: The objective of this study was to explore whether soluble programmed death ligand 1 (sPD-L1) is a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC). Methods: A comprehensive search of electronic databases was carried out. Original studies with inclusion of sPD-L1, progression-free survival, and overall survival in NSCLC were eligible. The primary endpoints were overall survival and progression-free survival. Hazard ratios (HRs) and 95% confidence intervals (CIs) were applied for data analysis. Results: Eight studies involving 710 patients with NSCLC were included in the analysis. A pooled data analysis revealed that high levels of sPD-L1 were correlated with poorer overall survival (HR = 2.34; 95% CI = 1.82–3.00; P < 0.001) and progression-free survival (HR = 2.35; 95% CI = 1.62–3.40, P < 0.001). A subgroup analysis revealed that high levels of sPD-L1 were correlated with poor overall survival in patients treated with immunotherapy (HR = 2.40; 95% CI = 1.79–3.22; P < 0.001). Conclusion: This pooled analysis of published data suggests that sPD-L1 may serve as a readily available biomarker for survival in NSCLC patients treated with ICI based treatment. Prospective studies with well-designed standard assessment methods should be conducted to validate the prognostic role of sPD-L1 in NSCLC. |
Persistent Identifier | http://hdl.handle.net/10722/344101 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 1.066 |
DC Field | Value | Language |
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dc.contributor.author | Liao, Guixiang | - |
dc.contributor.author | Zhao, Zhihong | - |
dc.contributor.author | Qian, Yuting | - |
dc.contributor.author | Ling, Xiean | - |
dc.contributor.author | Chen, Shanyi | - |
dc.contributor.author | Li, Xianming | - |
dc.contributor.author | Kong, FS | - |
dc.date.accessioned | 2024-07-03T08:40:39Z | - |
dc.date.available | 2024-07-03T08:40:39Z | - |
dc.date.issued | 2021-12-23 | - |
dc.identifier.citation | Frontiers in Oncology, 2021, v. 11 | - |
dc.identifier.issn | 2234-943X | - |
dc.identifier.uri | http://hdl.handle.net/10722/344101 | - |
dc.description.abstract | <p><strong>Objective:</strong> The objective of this study was to explore whether soluble programmed death ligand 1 (sPD-L1) is a potential prognostic biomarker in patients with non-small cell lung cancer (NSCLC).</p><p><strong>Methods:</strong> A comprehensive search of electronic databases was carried out. Original studies with inclusion of sPD-L1, progression-free survival, and overall survival in NSCLC were eligible. The primary endpoints were overall survival and progression-free survival. Hazard ratios (HRs) and 95% confidence intervals (CIs) were applied for data analysis.</p><p><strong>Results:</strong> Eight studies involving 710 patients with NSCLC were included in the analysis. A pooled data analysis revealed that high levels of sPD-L1 were correlated with poorer overall survival (HR = 2.34; 95% CI = 1.82–3.00; <em>P</em> < 0.001) and progression-free survival (HR = 2.35; 95% CI = 1.62–3.40, <em>P</em> < 0.001). A subgroup analysis revealed that high levels of sPD-L1 were correlated with poor overall survival in patients treated with immunotherapy (HR = 2.40; 95% CI = 1.79–3.22; <em>P</em> < 0.001).</p><p><strong>Conclusion:</strong> This pooled analysis of published data suggests that sPD-L1 may serve as a readily available biomarker for survival in NSCLC patients treated with ICI based treatment. Prospective studies with well-designed standard assessment methods should be conducted to validate the prognostic role of sPD-L1 in NSCLC.</p> | - |
dc.language | eng | - |
dc.publisher | Frontiers Media | - |
dc.relation.ispartof | Frontiers in Oncology | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | immune checkpoint inhibitors | - |
dc.subject | immunotherapy | - |
dc.subject | non-small cell lung cancer | - |
dc.subject | overall survival | - |
dc.subject | prognosis | - |
dc.subject | soluble programmed death ligand 1 | - |
dc.title | Prognostic Role of Soluble Programmed Death Ligand 1 in Non-Small Cell Lung Cancer: A Systematic Review and Meta-Analysis | - |
dc.type | Article | - |
dc.identifier.doi | 10.3389/fonc.2021.774131 | - |
dc.identifier.scopus | eid_2-s2.0-85122466238 | - |
dc.identifier.volume | 11 | - |
dc.identifier.eissn | 2234-943X | - |
dc.identifier.issnl | 2234-943X | - |