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Article: Low‐dose radiation therapy mobilizes antitumor immunity: New findings and future perspectives

TitleLow‐dose radiation therapy mobilizes antitumor immunity: New findings and future perspectives
Authors
Keywordsimmunomodulatory
low-dose radiotherapy
systemic tumor immune environment
tumor immune microenvironment
Issue Date1-Apr-2024
PublisherWiley
Citation
International Journal of Cancer, 2024, v. 154, n. 7, p. 1143-1157 How to Cite?
Abstract

Radiotherapy has unique immunostimulatory and immunosuppressive effects. Although high-dose radiotherapy has been found to have systemic antitumor effects, clinically significant abscopal effects were uncommon on the basis of irradiating single lesion. Low-dose radiation therapy (LDRT) emerges as a novel approach to enhance the antitumor immune response due to its role as a leverage to reshape the tumor immune microenvironment (TIME). In this article, from bench to bedside, we reviewed the possible immunomodulatory role of LDRT on TIME and systemic tumor immune environment, and outlined preclinical evidence and clinical application. We also discussed the current challenges when LDRT is used as a combination therapy, including the optimal dose, fraction, frequency, and combination of drugs. The advantage of low toxicity makes LDRT potential to be applied in multiple lesions to amplify antitumor immune response in polymetastatic disease, and its intersection with other disciplines might also make it a direction for radiotherapy-combined modalities.


Persistent Identifierhttp://hdl.handle.net/10722/343931
ISSN
2023 Impact Factor: 5.7
2023 SCImago Journal Rankings: 2.131

 

DC FieldValueLanguage
dc.contributor.authorZhou, Laiyan-
dc.contributor.authorLiu, Yuanxin-
dc.contributor.authorWu, Yuanjun-
dc.contributor.authorYang, Xue-
dc.contributor.authorKong, Spring FS-
dc.contributor.authorLu, You-
dc.contributor.authorXue, Jianxin-
dc.date.accessioned2024-06-18T03:42:54Z-
dc.date.available2024-06-18T03:42:54Z-
dc.date.issued2024-04-01-
dc.identifier.citationInternational Journal of Cancer, 2024, v. 154, n. 7, p. 1143-1157-
dc.identifier.issn0020-7136-
dc.identifier.urihttp://hdl.handle.net/10722/343931-
dc.description.abstract<p>Radiotherapy has unique immunostimulatory and immunosuppressive effects. Although high-dose radiotherapy has been found to have systemic antitumor effects, clinically significant abscopal effects were uncommon on the basis of irradiating single lesion. Low-dose radiation therapy (LDRT) emerges as a novel approach to enhance the antitumor immune response due to its role as a leverage to reshape the tumor immune microenvironment (TIME). In this article, from bench to bedside, we reviewed the possible immunomodulatory role of LDRT on TIME and systemic tumor immune environment, and outlined preclinical evidence and clinical application. We also discussed the current challenges when LDRT is used as a combination therapy, including the optimal dose, fraction, frequency, and combination of drugs. The advantage of low toxicity makes LDRT potential to be applied in multiple lesions to amplify antitumor immune response in polymetastatic disease, and its intersection with other disciplines might also make it a direction for radiotherapy-combined modalities.<br></p>-
dc.languageeng-
dc.publisherWiley-
dc.relation.ispartofInternational Journal of Cancer-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectimmunomodulatory-
dc.subjectlow-dose radiotherapy-
dc.subjectsystemic tumor immune environment-
dc.subjecttumor immune microenvironment-
dc.titleLow‐dose radiation therapy mobilizes antitumor immunity: New findings and future perspectives-
dc.typeArticle-
dc.identifier.doi10.1002/ijc.34801-
dc.identifier.scopuseid_2-s2.0-85178917539-
dc.identifier.volume154-
dc.identifier.issue7-
dc.identifier.spage1143-
dc.identifier.epage1157-
dc.identifier.eissn1097-0215-
dc.identifier.issnl0020-7136-

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