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Article: Ginseng-Epimedii formula ameliorated experimental Sjögren’s syndrome via reducing IL-6 production

TitleGinseng-Epimedii formula ameliorated experimental Sjögren’s syndrome via reducing IL-6 production
Authors
KeywordsAutoimmunity
Chinese medicine
Effector T cell
Microenvironment
Network pharmacology
Sjogren's syndrome
Issue Date23-Apr-2024
PublisherElsevier
Citation
Journal of Functional Foods, 2024, v. 116 How to Cite?
Abstract

Medicinal herbs have been recently investigated to explore their therapeutic potential on autoimmune disorders, as an alternative treatment to relieve disease symptoms. Here, we sought to determine the immunomodulatory function of a Chinese medicine formula Ginseng-Epimedii (GE), constituted by Lycium barbarumGinsengEleutherococcus senticosus and Epimedium brevicornum, on mice with experimental Sjögren’s syndrome (ESS). We found that GE-treated ESS mice exhibited improved salivary gland function and decreased serum levels of autoantibodies. In line with the network pharmacology analysis, GE treatment suppressed IL-6 production by B cells and conventional dendritic cells, associated with decreased effector T cell subsets. Using co-culture assay and adoptive transfer model, we demonstrated that splenoctyes from ESS mice receiving GE treatment showed impaired capacity to drive pathogenic Th17 and T follicular helper cell differentiation. Thus, this study suggested the therapeutic potential of GE formula in treating SS, by skewing the microenvironment that unfavored effector T cell responses.


Persistent Identifierhttp://hdl.handle.net/10722/343829
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 0.900

 

DC FieldValueLanguage
dc.contributor.authorChen, Yacun-
dc.contributor.authorXie, Jing-
dc.contributor.authorWu, Meiling-
dc.contributor.authorYu, Sulan-
dc.contributor.authorShen, Jiangang-
dc.contributor.authorLin, Xiang-
dc.date.accessioned2024-06-11T07:51:55Z-
dc.date.available2024-06-11T07:51:55Z-
dc.date.issued2024-04-23-
dc.identifier.citationJournal of Functional Foods, 2024, v. 116-
dc.identifier.issn1756-4646-
dc.identifier.urihttp://hdl.handle.net/10722/343829-
dc.description.abstract<p>Medicinal herbs have been recently investigated to explore their therapeutic potential on autoimmune disorders, as an alternative treatment to relieve disease symptoms. Here, we sought to determine the immunomodulatory function of a Chinese medicine formula Ginseng-Epimedii (GE), constituted by <em>Lycium barbarum</em>, <em>Ginseng</em>, <em>Eleutherococcus senticosus</em> and <em>Epimedium brevicornum</em>, on mice with experimental Sjögren’s syndrome (ESS). We found that GE-treated ESS mice exhibited improved salivary gland function and decreased serum levels of autoantibodies. In line with the network pharmacology analysis, GE treatment suppressed IL-6 production by B cells and conventional dendritic cells, associated with decreased effector T cell subsets. Using co-culture assay and adoptive transfer model, we demonstrated that splenoctyes from ESS mice receiving GE treatment showed impaired capacity to drive pathogenic Th17 and T follicular helper cell differentiation. Thus, this study suggested the therapeutic potential of GE formula in treating SS, by skewing the microenvironment that unfavored effector T cell responses.<br></p>-
dc.languageeng-
dc.publisherElsevier-
dc.relation.ispartofJournal of Functional Foods-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAutoimmunity-
dc.subjectChinese medicine-
dc.subjectEffector T cell-
dc.subjectMicroenvironment-
dc.subjectNetwork pharmacology-
dc.subjectSjogren's syndrome-
dc.titleGinseng-Epimedii formula ameliorated experimental Sjögren’s syndrome via reducing IL-6 production-
dc.typeArticle-
dc.identifier.doi10.1016/j.jff.2024.106198-
dc.identifier.scopuseid_2-s2.0-85190852319-
dc.identifier.volume116-
dc.identifier.issnl1756-4646-

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