RING1A/PRC1 inhibition as a novel broad-spectrum antiviral strategy

Abstract

Epigenetic research has been increasingly used to investigate the pathogenesis of infectious and non-infectious diseases. The fact that many diseases manifest when incorrect epigenetic markers are inserted, introduced, or removed at the incorrect time or location illustrates the importance of epigenetics for regulating physiological development in organisms. As a critical element of cellular proliferation, epigenetic modulations have been considered a potential strategy for treating cancers, congenital anomalies, autoimmunity, as well as latent HIV infection.

Recent studies have also revealed the potential correlation between epigenetic regulations and host innate immune responses in viral infections. In this thesis, I aimed to investigate the role of epigenetic markers in the pathogenesis and treatment of emerging viral infections.

The novel findings in this thesis demonstrated novel mechanistic insights at the intersection of epigenetic regulation and viral infection, which may facilitate the development of novel broad-spectrum antiviral strategies for emerging viral infections