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Article: The impact of anxiety on gait impairments in Parkinson’s disease: insights from sensor-based gait analysis

TitleThe impact of anxiety on gait impairments in Parkinson’s disease: insights from sensor-based gait analysis
Authors
KeywordsAnxiety
Gait analysis
Parkinson’s disease
Treatment
Wearable sensors
Issue Date30-Apr-2024
PublisherBioMed Central
Citation
Journal of NeuroEngineering and Rehabilitation, 2024, v. 21, n. 1 How to Cite?
Abstract

Background Sensor-based gait analysis provides a robust quantitative tool for assessing gait impairments and their associated factors in Parkinson’s disease (PD). Anxiety is observed to interfere with gait clinically, but this has been poorly investigated. Our purpose is to utilize gait analysis to uncover the effect of anxiety on gait in patients with PD.

Methods We enrolled 38 and 106 PD patients with and without anxiety, respectively. Gait parameters were quantitively examined and compared between two groups both in single-task (ST) and dual-task (DT) walking tests. Multiple linear regression was applied to evaluate whether anxiety independently contributed to gait impairments.

Results During ST, PD patients with anxiety presented significantly shorter stride length, lower gait velocity, longer stride time and stance time, longer stance phase, smaller toe-off (TO) and heel-strike (HS) angles than those without anxiety. While under DT status, the differences were diminished. Multiple linear regression analysis demonstrated that anxiety was an independent factor to a serials of gait parameters, particularly ST-TO (B = -2.599, (-4.82, -0.38)), ST-HS (B = -2.532, (-4.71, -0.35)), ST-TO-CV (B = 4.627, (1.71, 7.64)), ST-HS-CV(B = 4.597, (1.66, 7.53)), ST stance phase (B = 1.4, (0.22, 2.58)), and DT stance phase (B = 1.749, (0.56, 2.94)).

Conclusion Our study discovered that anxiety has a significant impact on gait impairments in PD patients, especially exacerbating shuffling steps and prolonging stance phase. These findings highlight the importance of addressing anxiety in PD precision therapy to achieve better treatment outcomes.

Keywords Gait analysis, Parkinson’s disease, Anxiety, Wearable sensors, Treatment


Persistent Identifierhttp://hdl.handle.net/10722/343569
ISSN
2023 Impact Factor: 5.2
2023 SCImago Journal Rankings: 1.291

 

DC FieldValueLanguage
dc.contributor.authorZhang, Xiaodan-
dc.contributor.authorJin, Yulan-
dc.contributor.authorWang, Mateng-
dc.contributor.authorJi, Chengcheng-
dc.contributor.authorChen, Zhaoying-
dc.contributor.authorFan, Weinv-
dc.contributor.authorRainer, Timothy Hudson-
dc.contributor.authorGuan, Qiongfeng-
dc.contributor.authorLi, Qianyun-
dc.date.accessioned2024-05-21T03:11:52Z-
dc.date.available2024-05-21T03:11:52Z-
dc.date.issued2024-04-30-
dc.identifier.citationJournal of NeuroEngineering and Rehabilitation, 2024, v. 21, n. 1-
dc.identifier.issn1743-0003-
dc.identifier.urihttp://hdl.handle.net/10722/343569-
dc.description.abstract<h3>Background Sensor-based gait analysis provides a robust quantitative tool for assessing gait impairments and their associated factors in Parkinson’s disease (PD). Anxiety is observed to interfere with gait clinically, but this has been poorly investigated. Our purpose is to utilize gait analysis to uncover the effect of anxiety on gait in patients with PD. <br></h3><h3>Methods We enrolled 38 and 106 PD patients with and without anxiety, respectively. Gait parameters were quantitively examined and compared between two groups both in single-task (ST) and dual-task (DT) walking tests. Multiple linear regression was applied to evaluate whether anxiety independently contributed to gait impairments. <br></h3><h3>Results During ST, PD patients with anxiety presented significantly shorter stride length, lower gait velocity, longer stride time and stance time, longer stance phase, smaller toe-off (TO) and heel-strike (HS) angles than those without anxiety. While under DT status, the differences were diminished. Multiple linear regression analysis demonstrated that anxiety was an independent factor to a serials of gait parameters, particularly ST-TO (B = -2.599, (-4.82, -0.38)), ST-HS (B = -2.532, (-4.71, -0.35)), ST-TO-CV (B = 4.627, (1.71, 7.64)), ST-HS-CV(B = 4.597, (1.66, 7.53)), ST stance phase (B = 1.4, (0.22, 2.58)), and DT stance phase (B = 1.749, (0.56, 2.94)). <br></h3><h3>Conclusion Our study discovered that anxiety has a significant impact on gait impairments in PD patients, especially exacerbating shuffling steps and prolonging stance phase. These findings highlight the importance of addressing anxiety in PD precision therapy to achieve better treatment outcomes. <br></h3><h3>Keywords Gait analysis, Parkinson’s disease, Anxiety, Wearable sensors, Treatment<br></h3>-
dc.languageeng-
dc.publisherBioMed Central-
dc.relation.ispartofJournal of NeuroEngineering and Rehabilitation-
dc.rightsThis work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.-
dc.subjectAnxiety-
dc.subjectGait analysis-
dc.subjectParkinson’s disease-
dc.subjectTreatment-
dc.subjectWearable sensors-
dc.titleThe impact of anxiety on gait impairments in Parkinson’s disease: insights from sensor-based gait analysis-
dc.typeArticle-
dc.identifier.doi10.1186/s12984-024-01364-3-
dc.identifier.scopuseid_2-s2.0-85191850976-
dc.identifier.volume21-
dc.identifier.issue1-
dc.identifier.eissn1743-0003-
dc.identifier.issnl1743-0003-

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