File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1126/science.291.5501.138
- Scopus: eid_2-s2.0-0035808602
- PMID: 11141567
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Differential shunting of EPSPs by action potentials
Title | Differential shunting of EPSPs by action potentials |
---|---|
Authors | |
Issue Date | 2001 |
Citation | Science, 2001, v. 291, n. 5501, p. 138-141 How to Cite? |
Abstract | Neurons encode information and communicate via action potentials, which are generated following the summation of synaptic events. It is commonly assumed that action potentials reset the membrane potential completely, allowing another round of synaptic integration to begin. We show here that the conductances underlying the action potential act instead as a variable reset of synaptic integration. The strength of this reset is cell type-specific and depends on the kinetics, location, and timing of the synaptic input. As a consequence, distal synapses, as well as inputs mediated by N-methyl-D-aspartate receptor activation, can contribute disproportionately to synaptic integration during action potential firing. |
Persistent Identifier | http://hdl.handle.net/10722/343499 |
ISSN | 2023 Impact Factor: 44.7 2023 SCImago Journal Rankings: 11.902 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Häusser, M. | - |
dc.contributor.author | Major, G. | - |
dc.contributor.author | Stuart, G. J. | - |
dc.date.accessioned | 2024-05-10T09:08:36Z | - |
dc.date.available | 2024-05-10T09:08:36Z | - |
dc.date.issued | 2001 | - |
dc.identifier.citation | Science, 2001, v. 291, n. 5501, p. 138-141 | - |
dc.identifier.issn | 0036-8075 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343499 | - |
dc.description.abstract | Neurons encode information and communicate via action potentials, which are generated following the summation of synaptic events. It is commonly assumed that action potentials reset the membrane potential completely, allowing another round of synaptic integration to begin. We show here that the conductances underlying the action potential act instead as a variable reset of synaptic integration. The strength of this reset is cell type-specific and depends on the kinetics, location, and timing of the synaptic input. As a consequence, distal synapses, as well as inputs mediated by N-methyl-D-aspartate receptor activation, can contribute disproportionately to synaptic integration during action potential firing. | - |
dc.language | eng | - |
dc.relation.ispartof | Science | - |
dc.title | Differential shunting of EPSPs by action potentials | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1126/science.291.5501.138 | - |
dc.identifier.pmid | 11141567 | - |
dc.identifier.scopus | eid_2-s2.0-0035808602 | - |
dc.identifier.volume | 291 | - |
dc.identifier.issue | 5501 | - |
dc.identifier.spage | 138 | - |
dc.identifier.epage | 141 | - |