File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Cytomorphological Assessment in Aspirates of Ductal Carcinoma in situ: Correlations with Histopathologic Grade, Architectural Pattern, and Invasion

TitleCytomorphological Assessment in Aspirates of Ductal Carcinoma in situ: Correlations with Histopathologic Grade, Architectural Pattern, and Invasion
Authors
KeywordsBreast
Ductal carcinoma in situ
Fine-needle aspiration biopsy
Issue Date2023
Citation
Acta Cytologica, 2023, v. 68, n. 1, p. 45-53 How to Cite?
AbstractIntroduction: Fine-needle aspiration biopsy (FNAB) of the breast is an effective and widely adopted diagnostic technique. Histopathologic grading of ductal carcinoma in situ (DCIS) has prognostic significance. In this current study, FNAB of DCIS was reviewed to identify parameters that predict grading, histopathologic architecture, and presence of invasion in DCIS. Methods: Aspirates from histopathology-proven cases of DCIS were retrieved and reviewed for cytomorphologic parameters including cellularity, composition, epithelial fragment architecture cellular/nuclear features. Results: In total 104 aspirates were reviewed. Cytopathologic cellular features – large nuclear size (p = 0.005), prominent nucleoli (p = 0.011), increased nuclear membrane irregularity (p = 0.043), high variation in nuclear size (p = 0.025), and presence of apoptotic figures in epithelial structures (p < 0.001); and background debris (p = 0.033) correlated with a high-grade diagnosis. Cytoplasmic vacuolation (p = 0.034) was seen exclusively in non-high-grade aspirates. Epithelial fragment architecture did not correlate with grading. A predominance (≥50%) of solid aggregates and papillary fragments on FNAB correlated with histopathologically solid (p = 0.039, p = 0.005) and papillary (p = 0.029, < p = 0.001) patterns. No parameter showed correlation with invasion. Conclusion: FNAB is effective in predicting DCIS grading. Epithelial fragment architecture assessment is limited to papillary or solid types, and FNAB cannot predict focal invasion in DCIS.
Persistent Identifierhttp://hdl.handle.net/10722/343457
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.565

 

DC FieldValueLanguage
dc.contributor.authorLi, Joshua J.X.-
dc.contributor.authorChow, Maria B.C.Y.-
dc.contributor.authorNg, Joanna K.M.-
dc.contributor.authorTsang, Julia Y.-
dc.contributor.authorTse, Gary M.-
dc.date.accessioned2024-05-10T09:08:17Z-
dc.date.available2024-05-10T09:08:17Z-
dc.date.issued2023-
dc.identifier.citationActa Cytologica, 2023, v. 68, n. 1, p. 45-53-
dc.identifier.issn0001-5547-
dc.identifier.urihttp://hdl.handle.net/10722/343457-
dc.description.abstractIntroduction: Fine-needle aspiration biopsy (FNAB) of the breast is an effective and widely adopted diagnostic technique. Histopathologic grading of ductal carcinoma in situ (DCIS) has prognostic significance. In this current study, FNAB of DCIS was reviewed to identify parameters that predict grading, histopathologic architecture, and presence of invasion in DCIS. Methods: Aspirates from histopathology-proven cases of DCIS were retrieved and reviewed for cytomorphologic parameters including cellularity, composition, epithelial fragment architecture cellular/nuclear features. Results: In total 104 aspirates were reviewed. Cytopathologic cellular features – large nuclear size (p = 0.005), prominent nucleoli (p = 0.011), increased nuclear membrane irregularity (p = 0.043), high variation in nuclear size (p = 0.025), and presence of apoptotic figures in epithelial structures (p < 0.001); and background debris (p = 0.033) correlated with a high-grade diagnosis. Cytoplasmic vacuolation (p = 0.034) was seen exclusively in non-high-grade aspirates. Epithelial fragment architecture did not correlate with grading. A predominance (≥50%) of solid aggregates and papillary fragments on FNAB correlated with histopathologically solid (p = 0.039, p = 0.005) and papillary (p = 0.029, < p = 0.001) patterns. No parameter showed correlation with invasion. Conclusion: FNAB is effective in predicting DCIS grading. Epithelial fragment architecture assessment is limited to papillary or solid types, and FNAB cannot predict focal invasion in DCIS.-
dc.languageeng-
dc.relation.ispartofActa Cytologica-
dc.subjectBreast-
dc.subjectDuctal carcinoma in situ-
dc.subjectFine-needle aspiration biopsy-
dc.titleCytomorphological Assessment in Aspirates of Ductal Carcinoma in situ: Correlations with Histopathologic Grade, Architectural Pattern, and Invasion-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000535836-
dc.identifier.pmid38128502-
dc.identifier.scopuseid_2-s2.0-85189856574-
dc.identifier.volume68-
dc.identifier.issue1-
dc.identifier.spage45-
dc.identifier.epage53-
dc.identifier.eissn1938-2650-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats