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Article: Bronchial cytology of pulmonary adenoid cystic carcinoma – A multi-institute series with emphasis on immunocytochemistry

TitleBronchial cytology of pulmonary adenoid cystic carcinoma – A multi-institute series with emphasis on immunocytochemistry
Authors
KeywordsAdenoid cystic carcinoma
Bronchial brushing
Bronchial cytology
Broncho-alveolar lavage
Issue Date2023
Citation
Annals of Diagnostic Pathology, 2023, v. 64, article no. 152132 How to Cite?
AbstractBackground: Pulmonary adenoid cystic carcinoma (AdCC) is a central and superficial primary lung neoplasm, well-suited for sampling by bronchial cytology. This study aims to review the cytologic features of pulmonary AdCC on bronchial cytology, and to report an experience of applying immunocytochemistry on this rare entity. Methods: A multi-institute review of bronchial cytology specimens from histologically proven pulmonary AdCCs was performed. Published cases of bronchial cytology of pulmonary AdCC were reviewed. The cytologic features and immunocytochemical profile for pulmonary AdCC was summarized and compared with pertinent differentials. Results: A total of 16 specimens from eight patients were retrieved. The initial cytologic diagnoses were negative (n = 7), atypia (n = 6), suspicious (n = 2) and AdCC (n = 1). Retrospective review showed eight bronchial cytology specimens (including five cases of atypia) with tumor cells present. The tumor cells displayed small basaloid nuclei with occasional small nucleoli, mild nuclear atypia, and scanty cytoplasm. Architectural patterns observed included clusters, tubules, solid sheets, three-dimensional balls, papillary-like fronds, and complex cribriform structures. Basement-membrane-like material, free or associated with tumor cells, were seen in all cases. Immunocytochemistry was performed in one specimen. MYB was positive. TTF-1, synaptophysin and chromogranin were negative. Epithelial and basal markers demonstrated a dual cell population. Literature review yielded 28 cases. Cytologic features described were similar except for cytoplasmic vacuolation in one case. Conclusion: Basement membrane-like material is specific for AdCC. MYB positivity, TTF-1 and neuroendocrine marker negativity, support a diagnosis of AdCC. Other immunocytochemistry and cytologic features overlap significantly with adenocarcinoma and small cell carcinoma of lung.
Persistent Identifierhttp://hdl.handle.net/10722/343414
ISSN
2023 Impact Factor: 1.5
2023 SCImago Journal Rankings: 0.575

 

DC FieldValueLanguage
dc.contributor.authorNg, Joanna K.M.-
dc.contributor.authorChan, Ka Pang-
dc.contributor.authorTse, Gary M.-
dc.contributor.authorLi, Joshua J.X.-
dc.date.accessioned2024-05-10T09:07:57Z-
dc.date.available2024-05-10T09:07:57Z-
dc.date.issued2023-
dc.identifier.citationAnnals of Diagnostic Pathology, 2023, v. 64, article no. 152132-
dc.identifier.issn1092-9134-
dc.identifier.urihttp://hdl.handle.net/10722/343414-
dc.description.abstractBackground: Pulmonary adenoid cystic carcinoma (AdCC) is a central and superficial primary lung neoplasm, well-suited for sampling by bronchial cytology. This study aims to review the cytologic features of pulmonary AdCC on bronchial cytology, and to report an experience of applying immunocytochemistry on this rare entity. Methods: A multi-institute review of bronchial cytology specimens from histologically proven pulmonary AdCCs was performed. Published cases of bronchial cytology of pulmonary AdCC were reviewed. The cytologic features and immunocytochemical profile for pulmonary AdCC was summarized and compared with pertinent differentials. Results: A total of 16 specimens from eight patients were retrieved. The initial cytologic diagnoses were negative (n = 7), atypia (n = 6), suspicious (n = 2) and AdCC (n = 1). Retrospective review showed eight bronchial cytology specimens (including five cases of atypia) with tumor cells present. The tumor cells displayed small basaloid nuclei with occasional small nucleoli, mild nuclear atypia, and scanty cytoplasm. Architectural patterns observed included clusters, tubules, solid sheets, three-dimensional balls, papillary-like fronds, and complex cribriform structures. Basement-membrane-like material, free or associated with tumor cells, were seen in all cases. Immunocytochemistry was performed in one specimen. MYB was positive. TTF-1, synaptophysin and chromogranin were negative. Epithelial and basal markers demonstrated a dual cell population. Literature review yielded 28 cases. Cytologic features described were similar except for cytoplasmic vacuolation in one case. Conclusion: Basement membrane-like material is specific for AdCC. MYB positivity, TTF-1 and neuroendocrine marker negativity, support a diagnosis of AdCC. Other immunocytochemistry and cytologic features overlap significantly with adenocarcinoma and small cell carcinoma of lung.-
dc.languageeng-
dc.relation.ispartofAnnals of Diagnostic Pathology-
dc.subjectAdenoid cystic carcinoma-
dc.subjectBronchial brushing-
dc.subjectBronchial cytology-
dc.subjectBroncho-alveolar lavage-
dc.titleBronchial cytology of pulmonary adenoid cystic carcinoma – A multi-institute series with emphasis on immunocytochemistry-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.anndiagpath.2023.152132-
dc.identifier.pmid36963153-
dc.identifier.scopuseid_2-s2.0-85150447905-
dc.identifier.volume64-
dc.identifier.spagearticle no. 152132-
dc.identifier.epagearticle no. 152132-
dc.identifier.eissn1532-8198-

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