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Article: Core needle biopsy diagnosis of fibroepithelial lesions of the breast: a diagnostic challenge

TitleCore needle biopsy diagnosis of fibroepithelial lesions of the breast: a diagnostic challenge
Authors
Keywordsbreast
fibroadenoma
Fibroepithelial lesion
phyllodes tumour
Issue Date2020
Citation
Pathology, 2020, v. 52, n. 6, p. 627-634 How to Cite?
AbstractFibroepithelial lesions (FEL) of the breast are biphasic neoplasms consisting of proliferative epithelial and stromal components and include fibroadenoma, phyllodes tumour and periductal stromal tumour. Core needle biopsy (CNB) is a commonly used diagnostic modality for investigation of breast lesions. As the accurate diagnosis of FEL requires integrated assessment of both epithelial and stromal components, this may create problems in small biopsies with limited sampling. In this review, common problems encountered in CNB of FEL are discussed, including establishing a diagnosis of borderline/malignant phyllodes tumour in a biopsy consisting of malignant spindle cells, differentiating phyllodes tumour from fibroadenoma on CNB, grading of phyllodes tumour of intermediate histological grade and assessment of periductal stromal tumours. The approaches are detailed systematically based on histology, immunohistochemistry and molecular characterisation. This comprehensive approach may aid in dealing with the overlapping histological appearance of FEL and sampling limitations of CNB.
Persistent Identifierhttp://hdl.handle.net/10722/343312
ISSN
2023 Impact Factor: 3.6
2023 SCImago Journal Rankings: 0.919

 

DC FieldValueLanguage
dc.contributor.authorLi, Joshua J.X.-
dc.contributor.authorTse, Gary M.-
dc.date.accessioned2024-05-10T09:07:07Z-
dc.date.available2024-05-10T09:07:07Z-
dc.date.issued2020-
dc.identifier.citationPathology, 2020, v. 52, n. 6, p. 627-634-
dc.identifier.issn0031-3025-
dc.identifier.urihttp://hdl.handle.net/10722/343312-
dc.description.abstractFibroepithelial lesions (FEL) of the breast are biphasic neoplasms consisting of proliferative epithelial and stromal components and include fibroadenoma, phyllodes tumour and periductal stromal tumour. Core needle biopsy (CNB) is a commonly used diagnostic modality for investigation of breast lesions. As the accurate diagnosis of FEL requires integrated assessment of both epithelial and stromal components, this may create problems in small biopsies with limited sampling. In this review, common problems encountered in CNB of FEL are discussed, including establishing a diagnosis of borderline/malignant phyllodes tumour in a biopsy consisting of malignant spindle cells, differentiating phyllodes tumour from fibroadenoma on CNB, grading of phyllodes tumour of intermediate histological grade and assessment of periductal stromal tumours. The approaches are detailed systematically based on histology, immunohistochemistry and molecular characterisation. This comprehensive approach may aid in dealing with the overlapping histological appearance of FEL and sampling limitations of CNB.-
dc.languageeng-
dc.relation.ispartofPathology-
dc.subjectbreast-
dc.subjectfibroadenoma-
dc.subjectFibroepithelial lesion-
dc.subjectphyllodes tumour-
dc.titleCore needle biopsy diagnosis of fibroepithelial lesions of the breast: a diagnostic challenge-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.pathol.2020.06.005-
dc.identifier.pmid32771211-
dc.identifier.scopuseid_2-s2.0-85089088478-
dc.identifier.volume52-
dc.identifier.issue6-
dc.identifier.spage627-
dc.identifier.epage634-
dc.identifier.eissn1465-3931-

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