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Article: Axillary Nodal Metastasis with Papillary Morphology: An Uncommon Origin

TitleAxillary Nodal Metastasis with Papillary Morphology: An Uncommon Origin
Authors
KeywordsAxillary lymph node metastasis
Endometrioid adenocarcinoma
Fine needle aspiration
Papillary morphology
Issue Date2020
Citation
Acta Cytologica, 2020, v. 64, n. 6, p. 612-616 How to Cite?
AbstractBackground: Metastases to axillary lymph nodes are commonly and readily confirmed by fine needle aspiration cytology (FNAC). Most likely, these arise from breast primaries. However, the diagnosis can become complicated when unusual cytomorphology is encountered. Case: We report a 60-year-old woman presenting with bilateral axillary lymphadenopathies but without breast lesions. History showed increasing CA-125 levels. FNAC yielded carcinoma cells showing prominent papillary pattern, being composed of mild to moderately differentiated malignant cells, with focal abortive glandular formation and squamous metaplasia. IHC stains were done and the tumor cells were PAX-8 positive, but GATA-3 and GCDFP-15 negative. Coupled with the clinical history, a diagnosis of metastatic endometrioid adenocarcinoma was made. Conclusion: Nodal metastases with papillary cytomorphology can rarely arise from nonbreast primaries. The presence of papillary pattern, particularly in the absence of a clinically detectable breast lesion, should raise the possibility of a metastasis. Correlation with patient history, imaging findings and judicious use of IHC studies are crucial for a correct diagnosis.
Persistent Identifierhttp://hdl.handle.net/10722/343305
ISSN
2023 Impact Factor: 1.6
2023 SCImago Journal Rankings: 0.565

 

DC FieldValueLanguage
dc.contributor.authorMarabi, Monalyn-
dc.contributor.authorLi, Joshua J.X.-
dc.contributor.authorChan, Wai Kong-
dc.contributor.authorTsang, Julia Y.-
dc.contributor.authorTse, Gary M.-
dc.date.accessioned2024-05-10T09:07:04Z-
dc.date.available2024-05-10T09:07:04Z-
dc.date.issued2020-
dc.identifier.citationActa Cytologica, 2020, v. 64, n. 6, p. 612-616-
dc.identifier.issn0001-5547-
dc.identifier.urihttp://hdl.handle.net/10722/343305-
dc.description.abstractBackground: Metastases to axillary lymph nodes are commonly and readily confirmed by fine needle aspiration cytology (FNAC). Most likely, these arise from breast primaries. However, the diagnosis can become complicated when unusual cytomorphology is encountered. Case: We report a 60-year-old woman presenting with bilateral axillary lymphadenopathies but without breast lesions. History showed increasing CA-125 levels. FNAC yielded carcinoma cells showing prominent papillary pattern, being composed of mild to moderately differentiated malignant cells, with focal abortive glandular formation and squamous metaplasia. IHC stains were done and the tumor cells were PAX-8 positive, but GATA-3 and GCDFP-15 negative. Coupled with the clinical history, a diagnosis of metastatic endometrioid adenocarcinoma was made. Conclusion: Nodal metastases with papillary cytomorphology can rarely arise from nonbreast primaries. The presence of papillary pattern, particularly in the absence of a clinically detectable breast lesion, should raise the possibility of a metastasis. Correlation with patient history, imaging findings and judicious use of IHC studies are crucial for a correct diagnosis.-
dc.languageeng-
dc.relation.ispartofActa Cytologica-
dc.subjectAxillary lymph node metastasis-
dc.subjectEndometrioid adenocarcinoma-
dc.subjectFine needle aspiration-
dc.subjectPapillary morphology-
dc.titleAxillary Nodal Metastasis with Papillary Morphology: An Uncommon Origin-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1159/000508241-
dc.identifier.pmid32526747-
dc.identifier.scopuseid_2-s2.0-85087182981-
dc.identifier.volume64-
dc.identifier.issue6-
dc.identifier.spage612-
dc.identifier.epage616-
dc.identifier.eissn1938-2650-

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