File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.celrep.2020.02.009
- Scopus: eid_2-s2.0-85080104302
- PMID: 32130904
Supplementary
- Citations:
- Appears in Collections:
Article: Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo
Title | Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo |
---|---|
Authors | |
Keywords | cerebellum climbing fiber glutamate spillover in vivo inhibition interneuron patch clamp Purkinje cell synaptic integration two-photon imaging |
Issue Date | 2020 |
Citation | Cell Reports, 2020, v. 30, n. 9, p. 3020-3035.e3 How to Cite? |
Abstract | The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood. In the cerebellar cortex, molecular layer interneurons and their targets, Purkinje cells, receive excitatory inputs from granule cells and climbing fibers. Using dual patch-clamp recordings from interneurons and Purkinje cells in vivo, we probe the spatiotemporal interactions between these circuit elements. We show that single interneuron spikes can potently inhibit Purkinje cell output, depending on interneuron location. Climbing fiber input activates many interneurons via glutamate spillover but results in inhibition of those interneurons that inhibit the same Purkinje cell receiving the climbing fiber input, forming a disinhibitory motif. These interneuron circuits are engaged during sensory processing, creating diverse pathway-specific response functions. These findings demonstrate how the powerful effect of single interneurons on Purkinje cell output can be sculpted by various interneuron circuit motifs to diversify cerebellar computations. |
Persistent Identifier | http://hdl.handle.net/10722/343294 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Arlt, Charlotte | - |
dc.contributor.author | Häusser, Michael | - |
dc.date.accessioned | 2024-05-10T09:06:59Z | - |
dc.date.available | 2024-05-10T09:06:59Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | Cell Reports, 2020, v. 30, n. 9, p. 3020-3035.e3 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343294 | - |
dc.description.abstract | The functional impact of single interneurons on neuronal output in vivo and how interneurons are recruited by physiological activity patterns remain poorly understood. In the cerebellar cortex, molecular layer interneurons and their targets, Purkinje cells, receive excitatory inputs from granule cells and climbing fibers. Using dual patch-clamp recordings from interneurons and Purkinje cells in vivo, we probe the spatiotemporal interactions between these circuit elements. We show that single interneuron spikes can potently inhibit Purkinje cell output, depending on interneuron location. Climbing fiber input activates many interneurons via glutamate spillover but results in inhibition of those interneurons that inhibit the same Purkinje cell receiving the climbing fiber input, forming a disinhibitory motif. These interneuron circuits are engaged during sensory processing, creating diverse pathway-specific response functions. These findings demonstrate how the powerful effect of single interneurons on Purkinje cell output can be sculpted by various interneuron circuit motifs to diversify cerebellar computations. | - |
dc.language | eng | - |
dc.relation.ispartof | Cell Reports | - |
dc.subject | cerebellum | - |
dc.subject | climbing fiber | - |
dc.subject | glutamate spillover | - |
dc.subject | in vivo | - |
dc.subject | inhibition | - |
dc.subject | interneuron | - |
dc.subject | patch clamp | - |
dc.subject | Purkinje cell | - |
dc.subject | synaptic integration | - |
dc.subject | two-photon imaging | - |
dc.title | Microcircuit Rules Governing Impact of Single Interneurons on Purkinje Cell Output In Vivo | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.celrep.2020.02.009 | - |
dc.identifier.pmid | 32130904 | - |
dc.identifier.scopus | eid_2-s2.0-85080104302 | - |
dc.identifier.volume | 30 | - |
dc.identifier.issue | 9 | - |
dc.identifier.spage | 3020 | - |
dc.identifier.epage | 3035.e3 | - |
dc.identifier.eissn | 2211-1247 | - |