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Article: Closed-loop all-optical interrogation of neural circuits in vivo

TitleClosed-loop all-optical interrogation of neural circuits in vivo
Authors
Zhang, ZihuiRussell, Lloyd E.Packer, Adam M.Gauld, Oliver M.Häusser, Michael
Issue Date2018
Citation
Nature Methods, 2018, v. 15, n. 12, p. 1037-1040 How to Cite?
DOI: http://dx.doi.org/10.1038/s41592-018-0183-z
AbstractUnderstanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.
Persistent Identifierhttp://hdl.handle.net/10722/343272
ISSN
1548-7091
2023 Impact Factor: 36.1
2023 SCImago Journal Rankings: 14.796

 

DC FieldValueLanguage
dc.contributor.authorZhang, Zihui-
dc.contributor.authorRussell, Lloyd E.-
dc.contributor.authorPacker, Adam M.-
dc.contributor.authorGauld, Oliver M.-
dc.contributor.authorHäusser, Michael-
dc.date.accessioned2024-05-10T09:06:49Z-
dc.date.available2024-05-10T09:06:49Z-
dc.date.issued2018-
dc.identifier.citationNature Methods, 2018, v. 15, n. 12, p. 1037-1040-
dc.identifier.issn1548-7091-
dc.identifier.urihttp://hdl.handle.net/10722/343272-
dc.description.abstractUnderstanding the causal relationship between neural activity and behavior requires the ability to perform rapid and targeted interventions in ongoing activity. Here we describe a closed-loop all-optical strategy for dynamically controlling neuronal activity patterns in awake mice. We rapidly tailored and delivered two-photon optogenetic stimulation based on online readout of activity using simultaneous two-photon imaging, thus enabling the manipulation of neural circuit activity ‘on the fly’ during behavior.-
dc.languageeng-
dc.relation.ispartofNature Methods-
dc.titleClosed-loop all-optical interrogation of neural circuits in vivo-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1038/s41592-018-0183-z-
dc.identifier.pmid30420686-
dc.identifier.scopuseid_2-s2.0-85056633872-
dc.identifier.volume15-
dc.identifier.issue12-
dc.identifier.spage1037-
dc.identifier.epage1040-
dc.identifier.eissn1548-7105-

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