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- Publisher Website: 10.1055/s-0035-1545695
- Scopus: eid_2-s2.0-84924576749
- PMID: 25760384
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Article: The antigluconeogenic activity of cucurbitacins from Momordica charantia
Title | The antigluconeogenic activity of cucurbitacins from Momordica charantia |
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Authors | |
Keywords | antigluconeogenic activity Cucurbitaceae cucurbitacin kuguacins II-VI Momordica charantia PEPCK activity |
Issue Date | 2015 |
Citation | Planta Medica, 2015, v. 81, n. 4, p. 327-332 How to Cite? |
Abstract | Five new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5β,19-epoxycucurbit-23-en-7-on-3β,25-diol (1), 5β,19-epoxycucurbit-7,23-dion-3β,25-diol (2), 5β,19-epoxycucurbit-6-en-19,23-dion-3β,25-diol (3), 5β,19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3β,22-diol (4), and cucurbit-5-en-7,23-dion-3β,19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 μM) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 μM) showed around 20-30% inhibition on PEPCK activity. |
Persistent Identifier | http://hdl.handle.net/10722/343174 |
ISSN | 2023 Impact Factor: 2.1 2023 SCImago Journal Rankings: 0.445 |
DC Field | Value | Language |
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dc.contributor.author | Chen, Jian Chao | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.contributor.author | Chan, Judy Yuet Wa | - |
dc.contributor.author | Fung, Kwok Pui | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.contributor.author | Liu, Jie Qing | - |
dc.contributor.author | Zhou, Lin | - |
dc.contributor.author | Xie, Ming Jin | - |
dc.contributor.author | Qiu, Ming Hua | - |
dc.date.accessioned | 2024-05-10T09:06:02Z | - |
dc.date.available | 2024-05-10T09:06:02Z | - |
dc.date.issued | 2015 | - |
dc.identifier.citation | Planta Medica, 2015, v. 81, n. 4, p. 327-332 | - |
dc.identifier.issn | 0032-0943 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343174 | - |
dc.description.abstract | Five new cucurbitacins, kuguacins II-VI (1-5), along with five known analogues (6-10), were obtained from the fruit of Momordica charantia. Structures of the new compounds were elucidated as 5β,19-epoxycucurbit-23-en-7-on-3β,25-diol (1), 5β,19-epoxycucurbit-7,23-dion-3β,25-diol (2), 5β,19-epoxycucurbit-6-en-19,23-dion-3β,25-diol (3), 5β,19-epoxy-23,24,25,26,27-pentanorcucurbit-6-en-7,19-dion-3β,22-diol (4), and cucurbit-5-en-7,23-dion-3β,19,25-triol (5) by extensive spectroscopic and single-crystal X-ray diffraction analyses. Some cucurbitane compounds from this species were screened for their potential antidiabetic properties in terms of antigluconeogenic activity. As a result, compounds 1, 10, 11, and 12 (at 25-100 μM) showed concentration-dependent inhibition on glucose production from liver cells. In addition, compounds 11 and 12 (at 100 μM) showed around 20-30% inhibition on PEPCK activity. | - |
dc.language | eng | - |
dc.relation.ispartof | Planta Medica | - |
dc.subject | antigluconeogenic activity | - |
dc.subject | Cucurbitaceae | - |
dc.subject | cucurbitacin | - |
dc.subject | kuguacins II-VI | - |
dc.subject | Momordica charantia | - |
dc.subject | PEPCK activity | - |
dc.title | The antigluconeogenic activity of cucurbitacins from Momordica charantia | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1055/s-0035-1545695 | - |
dc.identifier.pmid | 25760384 | - |
dc.identifier.scopus | eid_2-s2.0-84924576749 | - |
dc.identifier.volume | 81 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 327 | - |
dc.identifier.epage | 332 | - |
dc.identifier.eissn | 1439-0221 | - |