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Article: Stachyose: One of the active fibroblast-proliferating components in the root of rehmanniae radix ( dì huáng)

TitleStachyose: One of the active fibroblast-proliferating components in the root of rehmanniae radix ( dì huáng)
Authors
KeywordsFibroblast proliferation
Rehmannia glutinosa
Rehmanniae Radix
Stachyose
Verbascoside
Issue Date2012
Citation
Journal of Traditional and Complementary Medicine, 2012, v. 2, n. 3, p. 227-234 How to Cite?
AbstractThis study aimed to investigate and compare the fibroblast-proliferating activities of different Rehmanniae Radix (RR) samples and its chemical components using human normal fibroblast cells Hs27. Those active components were quantified in differently treated RR samples using UPLC so as to correlate activity with component content. Our results showed that dried RR aqueous extract exhibited the most potent fibroblast-proliferating activity. Stronger effect was observed when ethanol with heating was applied in the extraction process. Stachyose and verbascoside were demonstrated for their first time to exhibit significant stimulatory effects on fibroblast proliferation. However, the proliferating effect of dried RR extract did not correlate with the stachyose content, and verbascoside was not responsible for the fibroblast proliferative effect of RR since it was undetectable in all samples. In conclusion, stachyose only contributed in part to the activity of RR, suggesting that other active components might be present and yet to be found. Copyright © 2011 Committee on Chinese Medicine and Pharmacy, Taiwan.
Persistent Identifierhttp://hdl.handle.net/10722/343150

 

DC FieldValueLanguage
dc.contributor.authorLai, Patrick-
dc.contributor.authorTo, Ming Ho-
dc.contributor.authorLau, Kit Man-
dc.contributor.authorLiu, Cheuk Lun-
dc.contributor.authorCheng, Ling-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorLau, Clara-
dc.date.accessioned2024-05-10T09:05:51Z-
dc.date.available2024-05-10T09:05:51Z-
dc.date.issued2012-
dc.identifier.citationJournal of Traditional and Complementary Medicine, 2012, v. 2, n. 3, p. 227-234-
dc.identifier.urihttp://hdl.handle.net/10722/343150-
dc.description.abstractThis study aimed to investigate and compare the fibroblast-proliferating activities of different Rehmanniae Radix (RR) samples and its chemical components using human normal fibroblast cells Hs27. Those active components were quantified in differently treated RR samples using UPLC so as to correlate activity with component content. Our results showed that dried RR aqueous extract exhibited the most potent fibroblast-proliferating activity. Stronger effect was observed when ethanol with heating was applied in the extraction process. Stachyose and verbascoside were demonstrated for their first time to exhibit significant stimulatory effects on fibroblast proliferation. However, the proliferating effect of dried RR extract did not correlate with the stachyose content, and verbascoside was not responsible for the fibroblast proliferative effect of RR since it was undetectable in all samples. In conclusion, stachyose only contributed in part to the activity of RR, suggesting that other active components might be present and yet to be found. Copyright © 2011 Committee on Chinese Medicine and Pharmacy, Taiwan.-
dc.languageeng-
dc.relation.ispartofJournal of Traditional and Complementary Medicine-
dc.subjectFibroblast proliferation-
dc.subjectRehmannia glutinosa-
dc.subjectRehmanniae Radix-
dc.subjectStachyose-
dc.subjectVerbascoside-
dc.titleStachyose: One of the active fibroblast-proliferating components in the root of rehmanniae radix ( dì huáng)-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/S2225-4110(16)30104-3-
dc.identifier.scopuseid_2-s2.0-84894537170-
dc.identifier.volume2-
dc.identifier.issue3-
dc.identifier.spage227-
dc.identifier.epage234-
dc.identifier.eissn2225-4110-

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