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Article: The aqueous extract of rhizome of gastrodia elata protected drosophila and PC12 cells against beta-amyloid-induced neurotoxicity

TitleThe aqueous extract of rhizome of gastrodia elata protected drosophila and PC12 cells against beta-amyloid-induced neurotoxicity
Authors
Issue Date2013
Citation
Evidence-based Complementary and Alternative Medicine, 2013, v. 2013, article no. 516741 How to Cite?
AbstractThis study aims to investigate the neuroprotective effect of the rhizome of Gastrodia elata (GE) aqueous extract on beta-amyloid(Aβ)-induced toxicity in vivo and in vitro. Transgenic Drosophila mutants with Aβ-induced neurodegeneration in pan-neuron and ommatidia were used to determine the efficacy of GE. The antiapoptotic and antioxidative mechanisms of GE were also studied in Aβ-treated pheochromocytoma (PC12) cells. In vivo studies demonstrated that GE (5 mg/g Drosophila media)-treated Drosophila possessed a longer lifespan, better locomotor function, and less-degenerated ommatidia when compared with the Aβ-expressing control (all P < 0.05). In vitro studies illustrated that GE increased the cell viability of Aβ-treated PC12 cells in dose-dependent manner, probably through attenuation of Aβ-induced oxidative and apoptotic stress. GE also significantly upregulated the enzymatic activities of catalase, superoxide dismutase, and glutathione peroxidase, leading to the decrease of reactive oxidation species production and apoptotic marker caspase-3 activity. In conclusion, our current data presented the first evidence that the aqueous extract of GE was capable of reducing the Aβ-induced neurodegeneration in Drosophila, possibly through inhibition of apoptosis and reduction of oxidative stress. GE aqueous extract could be developed as a promising herbal agent for neuroprotection and novel adjuvant therapies for Alzheimer's disease. © 2013 Chun-Fai Ng et al.
Persistent Identifierhttp://hdl.handle.net/10722/343135
ISSN
2021 Impact Factor: 2.650

 

DC FieldValueLanguage
dc.contributor.authorNg, Chun Fai-
dc.contributor.authorKo, Chun Hay-
dc.contributor.authorKoon, Chi Man-
dc.contributor.authorXian, Jia Wen-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorChan, Ho Yin Edwin-
dc.contributor.authorLau, Clara Bik San-
dc.date.accessioned2024-05-10T09:05:44Z-
dc.date.available2024-05-10T09:05:44Z-
dc.date.issued2013-
dc.identifier.citationEvidence-based Complementary and Alternative Medicine, 2013, v. 2013, article no. 516741-
dc.identifier.issn1741-427X-
dc.identifier.urihttp://hdl.handle.net/10722/343135-
dc.description.abstractThis study aims to investigate the neuroprotective effect of the rhizome of Gastrodia elata (GE) aqueous extract on beta-amyloid(Aβ)-induced toxicity in vivo and in vitro. Transgenic Drosophila mutants with Aβ-induced neurodegeneration in pan-neuron and ommatidia were used to determine the efficacy of GE. The antiapoptotic and antioxidative mechanisms of GE were also studied in Aβ-treated pheochromocytoma (PC12) cells. In vivo studies demonstrated that GE (5 mg/g Drosophila media)-treated Drosophila possessed a longer lifespan, better locomotor function, and less-degenerated ommatidia when compared with the Aβ-expressing control (all P < 0.05). In vitro studies illustrated that GE increased the cell viability of Aβ-treated PC12 cells in dose-dependent manner, probably through attenuation of Aβ-induced oxidative and apoptotic stress. GE also significantly upregulated the enzymatic activities of catalase, superoxide dismutase, and glutathione peroxidase, leading to the decrease of reactive oxidation species production and apoptotic marker caspase-3 activity. In conclusion, our current data presented the first evidence that the aqueous extract of GE was capable of reducing the Aβ-induced neurodegeneration in Drosophila, possibly through inhibition of apoptosis and reduction of oxidative stress. GE aqueous extract could be developed as a promising herbal agent for neuroprotection and novel adjuvant therapies for Alzheimer's disease. © 2013 Chun-Fai Ng et al.-
dc.languageeng-
dc.relation.ispartofEvidence-based Complementary and Alternative Medicine-
dc.titleThe aqueous extract of rhizome of gastrodia elata protected drosophila and PC12 cells against beta-amyloid-induced neurotoxicity-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1155/2013/516741-
dc.identifier.scopuseid_2-s2.0-84885462810-
dc.identifier.volume2013-
dc.identifier.spagearticle no. 516741-
dc.identifier.epagearticle no. 516741-
dc.identifier.eissn1741-4288-

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