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Article: Design, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors

TitleDesign, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors
Authors
Shing, Tony K.M.Ng, Wai LungChan, Judy Y.W.Lau, Clara B.S.
Keywordsallylation
antidiabetics
carbohydrate mimics
diastereoselectivity
SGLT2
Issue Date2013
Citation
Angewandte Chemie - International Edition, 2013, v. 52, n. 32, p. 8401-8405 How to Cite?
DOI: http://dx.doi.org/10.1002/anie.201302543
AbstractCombating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Persistent Identifierhttp://hdl.handle.net/10722/343128
ISSN
1433-7851
2023 Impact Factor: 16.1
2023 SCImago Journal Rankings: 5.300

 

DC FieldValueLanguage
dc.contributor.authorShing, Tony K.M.-
dc.contributor.authorNg, Wai Lung-
dc.contributor.authorChan, Judy Y.W.-
dc.contributor.authorLau, Clara B.S.-
dc.date.accessioned2024-05-10T09:05:40Z-
dc.date.available2024-05-10T09:05:40Z-
dc.date.issued2013-
dc.identifier.citationAngewandte Chemie - International Edition, 2013, v. 52, n. 32, p. 8401-8405-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/10722/343128-
dc.description.abstractCombating diabetes: A small-molecule carbohydrate mimic, pseudo-sergliflozin, was synthesized effectively by a regio- and stereoselective allylic substitution reaction. It was found to be a potent and selective inhibitor of a transporter protein - sodium-dependent glucose cotransporter 2 (SGLT2) - which is responsible for glucose reabsorption in the human body. It could be a lead compound for further development into an antidiabetic agent. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.-
dc.languageeng-
dc.relation.ispartofAngewandte Chemie - International Edition-
dc.subjectallylation-
dc.subjectantidiabetics-
dc.subjectcarbohydrate mimics-
dc.subjectdiastereoselectivity-
dc.subjectSGLT2-
dc.titleDesign, syntheses, and SAR studies of carbocyclic analogues of sergliflozin as potent sodium-dependent glucose cotransporter 2 inhibitors-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/anie.201302543-
dc.identifier.pmid23784919-
dc.identifier.scopuseid_2-s2.0-84882244111-
dc.identifier.volume52-
dc.identifier.issue32-
dc.identifier.spage8401-
dc.identifier.epage8405-
dc.identifier.eissn1521-3773-

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