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Article: Anti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica

TitleAnti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica
Authors
KeywordsAngiogenesis
Bigelovin
Cell adhesion molecules
HMEC-1
Inula helianthus-aquatica
Zebrafish
Issue Date2013
Citation
European Journal of Medicinal Chemistry, 2013, v. 59, p. 243-252 How to Cite?
AbstractBigelovin is a sesquiterpene lactone isolated from the plant Inula helianthus-aquatica which was traditionally used in cancer treatment in Yunnan, China. The potent apoptotic activities of bigelovin in human leukemia U937 cells were shown in our previous study. The present study investigated the anti-angiogenic and immunomodulatory effects of bigelovin using transgenic zebrafish Tg(fli1a:EGFP)y1 with fluorescent blood vessels and human peripheral blood mononuclear cells (PBMCs), respectively. Furthermore, the inhibitory activities of bigelovin on the human endothelial cell adhesion molecules (CAMs) were also examined. Our results showed that the growth of subintestinal vessels of the bigelovin-treated zebrafish embryos was significantly inhibited and the gene expressions in angiogenesis signaling pathways (e.g. Ang2 and Tie2) of the zebrafish were down-regulated after bigelovin treatment. Besides, the proliferation and Th1 cytokines productions (e.g. IFN-γ, IL-2 and IL-12) were suppressed in bigelovin-treated PBMCs. On the other hand, bigelovin was shown to significantly inhibit the human monocyte adhesion to human endothelial cells and the gene expressions of inflammation-related CAMs (e.g. ICAM-1, VCAM-1 and E-selectin) were significantly down-regulated in bigelovin-treated human endothelial cells. In summary, our data provide the first evidence that bigelovin possesses anti-angiogenic and immunomodulatory activities, suggesting bigelovin may exert multi-target functions against cancer in animal models.© 2012 Elsevier Masson SAS. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/343112
ISSN
2023 Impact Factor: 6.0
2023 SCImago Journal Rankings: 1.151

 

DC FieldValueLanguage
dc.contributor.authorYue, Grace G.L.-
dc.contributor.authorChan, Ben C.L.-
dc.contributor.authorKwok, Hin Fai-
dc.contributor.authorWong, Yuk Lau-
dc.contributor.authorLeung, Hoi Wing-
dc.contributor.authorJi, Chang Jiu-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorTan, Ning Hua-
dc.contributor.authorLau, Clara B.S.-
dc.date.accessioned2024-05-10T09:05:32Z-
dc.date.available2024-05-10T09:05:32Z-
dc.date.issued2013-
dc.identifier.citationEuropean Journal of Medicinal Chemistry, 2013, v. 59, p. 243-252-
dc.identifier.issn0223-5234-
dc.identifier.urihttp://hdl.handle.net/10722/343112-
dc.description.abstractBigelovin is a sesquiterpene lactone isolated from the plant Inula helianthus-aquatica which was traditionally used in cancer treatment in Yunnan, China. The potent apoptotic activities of bigelovin in human leukemia U937 cells were shown in our previous study. The present study investigated the anti-angiogenic and immunomodulatory effects of bigelovin using transgenic zebrafish Tg(fli1a:EGFP)y1 with fluorescent blood vessels and human peripheral blood mononuclear cells (PBMCs), respectively. Furthermore, the inhibitory activities of bigelovin on the human endothelial cell adhesion molecules (CAMs) were also examined. Our results showed that the growth of subintestinal vessels of the bigelovin-treated zebrafish embryos was significantly inhibited and the gene expressions in angiogenesis signaling pathways (e.g. Ang2 and Tie2) of the zebrafish were down-regulated after bigelovin treatment. Besides, the proliferation and Th1 cytokines productions (e.g. IFN-γ, IL-2 and IL-12) were suppressed in bigelovin-treated PBMCs. On the other hand, bigelovin was shown to significantly inhibit the human monocyte adhesion to human endothelial cells and the gene expressions of inflammation-related CAMs (e.g. ICAM-1, VCAM-1 and E-selectin) were significantly down-regulated in bigelovin-treated human endothelial cells. In summary, our data provide the first evidence that bigelovin possesses anti-angiogenic and immunomodulatory activities, suggesting bigelovin may exert multi-target functions against cancer in animal models.© 2012 Elsevier Masson SAS. All rights reserved.-
dc.languageeng-
dc.relation.ispartofEuropean Journal of Medicinal Chemistry-
dc.subjectAngiogenesis-
dc.subjectBigelovin-
dc.subjectCell adhesion molecules-
dc.subjectHMEC-1-
dc.subjectInula helianthus-aquatica-
dc.subjectZebrafish-
dc.titleAnti-angiogenesis and immunomodulatory activities of an anti-tumor sesquiterpene bigelovin isolated from Inula helianthus-aquatica-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.ejmech.2012.11.029-
dc.identifier.pmid23231968-
dc.identifier.scopuseid_2-s2.0-84870673106-
dc.identifier.volume59-
dc.identifier.spage243-
dc.identifier.epage252-
dc.identifier.eissn1768-3254-

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