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Article: The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula

TitleThe roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula
Authors
KeywordsAtherosclerosis
Combination effect
Danshen
Gegen
Herbal formula
Pueraria lobata
Salvia miltiorrhiza
Issue Date2012
Citation
Journal of Ethnopharmacology, 2012, v. 143, n. 3, p. 859-866 How to Cite?
AbstractEthnopharmacological relevance: The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) are principle herbs of Chinese herbal formulae which have long been used to treat cardiovascular diseases. Aim of study: The present study validated the anti-atherogenic effects of three extracts, Danshen alone (DE), Gegen alone (GE) as well as DGE and interpreted their combination effects statistically. Materials and methods: The anti-atherogenic effects of the three extracts were studied in three assays with regards to inflammation, foam cell formation and vascular smooth muscle cell (vSMC) proliferation using lipopolysaccharide (LPS)-induced nitric oxide production model, macrophage foam cell formation model and platelet-derived growth factor (PDGF)-induced vSMC proliferation model, respectively. The combination effects of DGE were statistically analyzed using combination index (CI) and fixed-ratio experimental design. Results: The anti-atherogenic effects of the three extracts including anti-inflammation, anti-foam cell formation and anti-vSMC proliferation were demonstrated in this study. Their combination effects in anti-inflammation, anti-foam cell formation and anti-vSMC proliferation were found to be synergistic, additive and antagonistic, respectively. Conclusions: This study provided scientific support for the combination use of DGE on atherosclerosis and presented one of the first applications of statistical interpretations of the combination effects of the 2-herb formula. © 2012 Elsevier Ireland Ltd. All rights reserved.
Persistent Identifierhttp://hdl.handle.net/10722/343106
ISSN
2023 Impact Factor: 4.8
2023 SCImago Journal Rankings: 0.936

 

DC FieldValueLanguage
dc.contributor.authorWing-Shing Cheung, David-
dc.contributor.authorKoon, Chi Man-
dc.contributor.authorNg, Chun Fai-
dc.contributor.authorLeung, Ping Chung-
dc.contributor.authorFung, Kwok Pui-
dc.contributor.authorKar-Sing Poon, Simon-
dc.contributor.authorBik-San Lau, Clara-
dc.date.accessioned2024-05-10T09:05:29Z-
dc.date.available2024-05-10T09:05:29Z-
dc.date.issued2012-
dc.identifier.citationJournal of Ethnopharmacology, 2012, v. 143, n. 3, p. 859-866-
dc.identifier.issn0378-8741-
dc.identifier.urihttp://hdl.handle.net/10722/343106-
dc.description.abstractEthnopharmacological relevance: The roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) are principle herbs of Chinese herbal formulae which have long been used to treat cardiovascular diseases. Aim of study: The present study validated the anti-atherogenic effects of three extracts, Danshen alone (DE), Gegen alone (GE) as well as DGE and interpreted their combination effects statistically. Materials and methods: The anti-atherogenic effects of the three extracts were studied in three assays with regards to inflammation, foam cell formation and vascular smooth muscle cell (vSMC) proliferation using lipopolysaccharide (LPS)-induced nitric oxide production model, macrophage foam cell formation model and platelet-derived growth factor (PDGF)-induced vSMC proliferation model, respectively. The combination effects of DGE were statistically analyzed using combination index (CI) and fixed-ratio experimental design. Results: The anti-atherogenic effects of the three extracts including anti-inflammation, anti-foam cell formation and anti-vSMC proliferation were demonstrated in this study. Their combination effects in anti-inflammation, anti-foam cell formation and anti-vSMC proliferation were found to be synergistic, additive and antagonistic, respectively. Conclusions: This study provided scientific support for the combination use of DGE on atherosclerosis and presented one of the first applications of statistical interpretations of the combination effects of the 2-herb formula. © 2012 Elsevier Ireland Ltd. All rights reserved.-
dc.languageeng-
dc.relation.ispartofJournal of Ethnopharmacology-
dc.subjectAtherosclerosis-
dc.subjectCombination effect-
dc.subjectDanshen-
dc.subjectGegen-
dc.subjectHerbal formula-
dc.subjectPueraria lobata-
dc.subjectSalvia miltiorrhiza-
dc.titleThe roots of Salvia miltiorrhiza (Danshen) and Pueraria lobata (Gegen) inhibit atherogenic events: A study of the combination effects of the 2-herb formula-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1016/j.jep.2012.08.011-
dc.identifier.pmid22922086-
dc.identifier.scopuseid_2-s2.0-84866741459-
dc.identifier.volume143-
dc.identifier.issue3-
dc.identifier.spage859-
dc.identifier.epage866-
dc.identifier.eissn1872-7573-

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