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Article: Radix astragali and radix rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues

TitleRadix astragali and radix rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues
Authors
KeywordsChinese medicine
Diabetic mellitus
Fibroblast
Foot ulcer
Granulation tissue
Wound healing
Issue Date2009
Citation
Phytotherapy Research, 2009, v. 23, n. 6, p. 809-815 How to Cite?
AbstractOver 194 million people suffer from diabetes worldwide. The improper control of diabetes may result in diabetic foot ulcer or even amputation. Herbal medicine provides a means for treating diabetic foot ulcers for a large population in developing countries. The wound healing-enhancing activities of the principal herbs, Radix Astragali (RA) and Radix Rehmanniae (RR) in two clinically efficacious Chinese herbal formulae were studied in primary fibroblasts from diabetic foot ulcer patients. The 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide assay showed that RA and RR significantly enhanced the viability of fibroblasts isolated from foot ulcers of diabetic patients, even from those with no response to insulin treatment. The results in this study indicate that fibroblast viability enhancement effects of RA and RR likely underlie the healing effects of F1 and F2 in diabetic foot ulcers. Copyright © 2009 John Wiley & Sons, Ltd.
Persistent Identifierhttp://hdl.handle.net/10722/343049
ISSN
2023 Impact Factor: 6.1
2023 SCImago Journal Rankings: 1.277

 

DC FieldValueLanguage
dc.contributor.authorLau, T. W.-
dc.contributor.authorChan, Y. W.-
dc.contributor.authorLau, C. P.-
dc.contributor.authorLau, K. M.-
dc.contributor.authorLau, C. B.S.-
dc.contributor.authorFung, K. P.-
dc.contributor.authorLeung, P. C.-
dc.contributor.authorHo, Yuan Yuan-
dc.date.accessioned2024-05-10T09:05:03Z-
dc.date.available2024-05-10T09:05:03Z-
dc.date.issued2009-
dc.identifier.citationPhytotherapy Research, 2009, v. 23, n. 6, p. 809-815-
dc.identifier.issn0951-418X-
dc.identifier.urihttp://hdl.handle.net/10722/343049-
dc.description.abstractOver 194 million people suffer from diabetes worldwide. The improper control of diabetes may result in diabetic foot ulcer or even amputation. Herbal medicine provides a means for treating diabetic foot ulcers for a large population in developing countries. The wound healing-enhancing activities of the principal herbs, Radix Astragali (RA) and Radix Rehmanniae (RR) in two clinically efficacious Chinese herbal formulae were studied in primary fibroblasts from diabetic foot ulcer patients. The 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide assay showed that RA and RR significantly enhanced the viability of fibroblasts isolated from foot ulcers of diabetic patients, even from those with no response to insulin treatment. The results in this study indicate that fibroblast viability enhancement effects of RA and RR likely underlie the healing effects of F1 and F2 in diabetic foot ulcers. Copyright © 2009 John Wiley & Sons, Ltd.-
dc.languageeng-
dc.relation.ispartofPhytotherapy Research-
dc.subjectChinese medicine-
dc.subjectDiabetic mellitus-
dc.subjectFibroblast-
dc.subjectFoot ulcer-
dc.subjectGranulation tissue-
dc.subjectWound healing-
dc.titleRadix astragali and radix rehmanniae, the principal components of two antidiabetic foot ulcer herbal formulae, elicit viability-promoting effects on primary fibroblasts cultured from diabetic foot ulcer tissues-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1002/ptr.2649-
dc.identifier.pmid19148881-
dc.identifier.scopuseid_2-s2.0-67149091203-
dc.identifier.volume23-
dc.identifier.issue6-
dc.identifier.spage809-
dc.identifier.epage815-
dc.identifier.eissn1099-1573-

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