File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.jep.2008.03.018
- Scopus: eid_2-s2.0-44149118848
- PMID: 18479853
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Immunomodulatory and anti-SARS activities of Houttuynia cordata
Title | Immunomodulatory and anti-SARS activities of Houttuynia cordata |
---|---|
Authors | Lau, Kit ManLee, Kin MingKoon, Chi ManCheung, Crystal Sao FongLau, Ching PoHo, Hei MingLee, Mavis Yuk HaAu, Shannon Wing NgorCheng, Christopher Hon KiLau, Clara Bik SanTsui, Stephen Kwok WingWan, David Chi CheongWaye, Mary Miu YeeWong, Kam BoWong, Chun KwokLam, Christopher Wai KeiLeung, Ping ChungFung, Kwok Pui |
Keywords | 3C-like protease Anti-viral Houttuynia cordata Immunomodulation RNA-dependent RNA polymerase SARS |
Issue Date | 2008 |
Citation | Journal of Ethnopharmacology, 2008, v. 118, n. 1, p. 79-85 How to Cite? |
Abstract | Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4+ and CD8+ T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16 g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS. © 2008 Elsevier Ireland Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/343031 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 0.936 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lau, Kit Man | - |
dc.contributor.author | Lee, Kin Ming | - |
dc.contributor.author | Koon, Chi Man | - |
dc.contributor.author | Cheung, Crystal Sao Fong | - |
dc.contributor.author | Lau, Ching Po | - |
dc.contributor.author | Ho, Hei Ming | - |
dc.contributor.author | Lee, Mavis Yuk Ha | - |
dc.contributor.author | Au, Shannon Wing Ngor | - |
dc.contributor.author | Cheng, Christopher Hon Ki | - |
dc.contributor.author | Lau, Clara Bik San | - |
dc.contributor.author | Tsui, Stephen Kwok Wing | - |
dc.contributor.author | Wan, David Chi Cheong | - |
dc.contributor.author | Waye, Mary Miu Yee | - |
dc.contributor.author | Wong, Kam Bo | - |
dc.contributor.author | Wong, Chun Kwok | - |
dc.contributor.author | Lam, Christopher Wai Kei | - |
dc.contributor.author | Leung, Ping Chung | - |
dc.contributor.author | Fung, Kwok Pui | - |
dc.date.accessioned | 2024-05-10T09:04:55Z | - |
dc.date.available | 2024-05-10T09:04:55Z | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | Journal of Ethnopharmacology, 2008, v. 118, n. 1, p. 79-85 | - |
dc.identifier.issn | 0378-8741 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343031 | - |
dc.description.abstract | Background: Severe acute respiratory syndrome (SARS) is a life-threatening form of pneumonia caused by SARS coronavirus (SARS-CoV). From late 2002 to mid 2003, it infected more than 8000 people worldwide, of which a majority of cases were found in China. Owing to the absence of definitive therapeutic Western medicines, Houttuynia cordata Thunb. (Saururaceae) (HC) was shortlisted by Chinese scientists to tackle SARS problem as it is conventionally used to treat pneumonia. Aim of the study: The present study aimed to explore the SARS-preventing mechanisms of HC in the immunological and anti-viral aspects. Results: Results showed that HC water extract could stimulate the proliferation of mouse splenic lymphocytes significantly and dose-dependently. By flow cytometry, it was revealed that HC increased the proportion of CD4+ and CD8+ T cells. Moreover, it caused a significant increase in the secretion of IL-2 and IL-10 by mouse splenic lymphocytes. In the anti-viral aspect, HC exhibited significant inhibitory effects on SARS-CoV 3C-like protease (3CLpro) and RNA-dependent RNA polymerase (RdRp). On the other hand, oral acute toxicity test demonstrated that HC was non-toxic to laboratory animals following oral administration at 16 g/kg. Conclusion: The results of this study provided scientific data to support the efficient and safe use of HC to combat SARS. © 2008 Elsevier Ireland Ltd. All rights reserved. | - |
dc.language | eng | - |
dc.relation.ispartof | Journal of Ethnopharmacology | - |
dc.subject | 3C-like protease | - |
dc.subject | Anti-viral | - |
dc.subject | Houttuynia cordata | - |
dc.subject | Immunomodulation | - |
dc.subject | RNA-dependent RNA polymerase | - |
dc.subject | SARS | - |
dc.title | Immunomodulatory and anti-SARS activities of Houttuynia cordata | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/j.jep.2008.03.018 | - |
dc.identifier.pmid | 18479853 | - |
dc.identifier.scopus | eid_2-s2.0-44149118848 | - |
dc.identifier.volume | 118 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 79 | - |
dc.identifier.epage | 85 | - |