File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1073/pnas.0701586104
- Scopus: eid_2-s2.0-34547485311
- PMID: 17592119
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Targeted dendrotomy reveals active and passive contributions of the dendritic tree to synaptic integration and neuronal output
Title | Targeted dendrotomy reveals active and passive contributions of the dendritic tree to synaptic integration and neuronal output |
---|---|
Authors | |
Keywords | Action potential Cerebellum Dendrite Modeling Neocortex |
Issue Date | 2007 |
Citation | Proceedings of the National Academy of Sciences of the United States of America, 2007, v. 104, n. 27, p. 11447-11452 How to Cite? |
Abstract | Neurons typically function as transduction devices, converting patterns of synaptic inputs, received on the dendrites, into trains of output action potentials in the axon. This transduction process is surprisingly complex and has been proposed to involve a two-way dialogue between axosomatic and dendritic compartments that can generate mutually interacting regenerative responses. To manipulate this process, we have developed a new approach for rapid and reversible occlusion or amputation of the primary dendrites of individual neurons in brain slices. By applying these techniques to cerebellar Purkinje and layer 5 cortical pyramidal neurons, we show directly that both the active and passive properties of dendrites differentially affect firing in the axon depending on the strength of stimulation. For weak excitation, dendrites act as a passive electrical load, raising spike threshold and dampening axonal excitability. For strong excitation, dendrites contribute regenerative inward currents, which trigger burst firing and enhance neuronal excitability. These findings provide direct support for the idea that dendritic morphology and conductances act in concert to regulate the excitability of the neuron. © 2007 by The National Academy of Sciences of the USA. |
Persistent Identifier | http://hdl.handle.net/10722/343022 |
ISSN | 2023 Impact Factor: 9.4 2023 SCImago Journal Rankings: 3.737 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Bekkers, John M. | - |
dc.contributor.author | Häusser, Michael | - |
dc.date.accessioned | 2024-05-10T09:04:50Z | - |
dc.date.available | 2024-05-10T09:04:50Z | - |
dc.date.issued | 2007 | - |
dc.identifier.citation | Proceedings of the National Academy of Sciences of the United States of America, 2007, v. 104, n. 27, p. 11447-11452 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343022 | - |
dc.description.abstract | Neurons typically function as transduction devices, converting patterns of synaptic inputs, received on the dendrites, into trains of output action potentials in the axon. This transduction process is surprisingly complex and has been proposed to involve a two-way dialogue between axosomatic and dendritic compartments that can generate mutually interacting regenerative responses. To manipulate this process, we have developed a new approach for rapid and reversible occlusion or amputation of the primary dendrites of individual neurons in brain slices. By applying these techniques to cerebellar Purkinje and layer 5 cortical pyramidal neurons, we show directly that both the active and passive properties of dendrites differentially affect firing in the axon depending on the strength of stimulation. For weak excitation, dendrites act as a passive electrical load, raising spike threshold and dampening axonal excitability. For strong excitation, dendrites contribute regenerative inward currents, which trigger burst firing and enhance neuronal excitability. These findings provide direct support for the idea that dendritic morphology and conductances act in concert to regulate the excitability of the neuron. © 2007 by The National Academy of Sciences of the USA. | - |
dc.language | eng | - |
dc.relation.ispartof | Proceedings of the National Academy of Sciences of the United States of America | - |
dc.subject | Action potential | - |
dc.subject | Cerebellum | - |
dc.subject | Dendrite | - |
dc.subject | Modeling | - |
dc.subject | Neocortex | - |
dc.title | Targeted dendrotomy reveals active and passive contributions of the dendritic tree to synaptic integration and neuronal output | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1073/pnas.0701586104 | - |
dc.identifier.pmid | 17592119 | - |
dc.identifier.scopus | eid_2-s2.0-34547485311 | - |
dc.identifier.volume | 104 | - |
dc.identifier.issue | 27 | - |
dc.identifier.spage | 11447 | - |
dc.identifier.epage | 11452 | - |