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- Publisher Website: 10.1142/S0192415X0600359X
- Scopus: eid_2-s2.0-32544431751
- PMID: 16437735
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Article: Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: A self-control study
Title | Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: A self-control study |
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Authors | |
Keywords | Blood lymphocytes CD4 CD8 Folium isatidis Folium mori Radix astragali SARS Traditional Chinese Medicine |
Issue Date | 2006 |
Citation | American Journal of Chinese Medicine, 2006, v. 34, n. 1, p. 13-21 How to Cite? |
Abstract | Traditional Chinese medicine (TCM) has been used for prevention and treatment of severe acute respiratory syndrome (SARS) in Hong Kong during the outbreak in spring 2003. We investigated the immunomodulating effects of an innovative TCM regimen derived from two herbal formulas (Sang Ju Yin and Yu Ping Feng San) for treating febrile diseases. Thirty-seven healthy volunteers were given the oral TCM regimen daily for 14 days. Peripheral venous blood samples were taken on days 0, 15 and 29 for hematology, biochemistry and immunology tests, including the measurement of blood lymphocyte subsets and plasma T-helper lymphocyte types 1 and 2 cytokines and receptor. After 3 months, 23 of the volunteers participated in a control study without TCM treatment for the same time course of blood tests. Two volunteers withdrew on day 2, due to headache and dizziness. All others remained well without any side effects. No participants showed significant changes in their blood test results, except that the T-lymphocyte CD4/CD8 ratio increased significantly from 1.31 ± 0.50 (mean ± SD) on day 0 to 1.41 ± 0.63 on day 15 (p ± 0.02), and reduced to 1.32 ± 0.47 on day 29 (p ± 0.05). In the control study, there were no changes in the CD4/CD8 ratio. The transient increase in CD4/CD8 ratio was likely due to the TCM intake. We postulate that the administration of the innovative TCM may have beneficial immunomodulatory effects for preventing viral infections including SARS. © 2006 World Scientific Publishing Company. |
Persistent Identifier | http://hdl.handle.net/10722/343012 |
ISSN | 2023 Impact Factor: 4.8 2023 SCImago Journal Rankings: 1.025 |
DC Field | Value | Language |
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dc.contributor.author | Poon, P. M.K. | - |
dc.contributor.author | Wong, C. K. | - |
dc.contributor.author | Fung, K. P. | - |
dc.contributor.author | Fong, C. Y.S. | - |
dc.contributor.author | Wong, E. L.Y. | - |
dc.contributor.author | Lau, J. T.F. | - |
dc.contributor.author | Leung, P. C. | - |
dc.contributor.author | Tsui, S. K.W. | - |
dc.contributor.author | Wan, D. C.C. | - |
dc.contributor.author | Waye, M. M.Y. | - |
dc.contributor.author | Au, S. W.N. | - |
dc.contributor.author | Lau, C. B.S. | - |
dc.contributor.author | Lam, C. Waikeilam K. | - |
dc.date.accessioned | 2024-05-10T09:04:46Z | - |
dc.date.available | 2024-05-10T09:04:46Z | - |
dc.date.issued | 2006 | - |
dc.identifier.citation | American Journal of Chinese Medicine, 2006, v. 34, n. 1, p. 13-21 | - |
dc.identifier.issn | 0192-415X | - |
dc.identifier.uri | http://hdl.handle.net/10722/343012 | - |
dc.description.abstract | Traditional Chinese medicine (TCM) has been used for prevention and treatment of severe acute respiratory syndrome (SARS) in Hong Kong during the outbreak in spring 2003. We investigated the immunomodulating effects of an innovative TCM regimen derived from two herbal formulas (Sang Ju Yin and Yu Ping Feng San) for treating febrile diseases. Thirty-seven healthy volunteers were given the oral TCM regimen daily for 14 days. Peripheral venous blood samples were taken on days 0, 15 and 29 for hematology, biochemistry and immunology tests, including the measurement of blood lymphocyte subsets and plasma T-helper lymphocyte types 1 and 2 cytokines and receptor. After 3 months, 23 of the volunteers participated in a control study without TCM treatment for the same time course of blood tests. Two volunteers withdrew on day 2, due to headache and dizziness. All others remained well without any side effects. No participants showed significant changes in their blood test results, except that the T-lymphocyte CD4/CD8 ratio increased significantly from 1.31 ± 0.50 (mean ± SD) on day 0 to 1.41 ± 0.63 on day 15 (p ± 0.02), and reduced to 1.32 ± 0.47 on day 29 (p ± 0.05). In the control study, there were no changes in the CD4/CD8 ratio. The transient increase in CD4/CD8 ratio was likely due to the TCM intake. We postulate that the administration of the innovative TCM may have beneficial immunomodulatory effects for preventing viral infections including SARS. © 2006 World Scientific Publishing Company. | - |
dc.language | eng | - |
dc.relation.ispartof | American Journal of Chinese Medicine | - |
dc.subject | Blood lymphocytes | - |
dc.subject | CD4 | - |
dc.subject | CD8 | - |
dc.subject | Folium isatidis | - |
dc.subject | Folium mori | - |
dc.subject | Radix astragali | - |
dc.subject | SARS | - |
dc.subject | Traditional Chinese Medicine | - |
dc.title | Immunomodulatory effects of a traditional Chinese medicine with potential antiviral activity: A self-control study | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1142/S0192415X0600359X | - |
dc.identifier.pmid | 16437735 | - |
dc.identifier.scopus | eid_2-s2.0-32544431751 | - |
dc.identifier.volume | 34 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 13 | - |
dc.identifier.epage | 21 | - |