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- Publisher Website: 10.1097/01.gme.0000184419.65943.01
- Scopus: eid_2-s2.0-27944466104
- PMID: 16278617
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Article: Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: Is it appropriate?
Title | Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: Is it appropriate? |
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Authors | |
Keywords | Angelica sinensis Breast cancer Dong quai Estrogen receptor Herbal therapy Menopause |
Issue Date | 2005 |
Citation | Menopause, 2005, v. 12, n. 6, p. 734-740 How to Cite? |
Abstract | Objective: Regarding the growing use of alternative therapies for peri- or postmenopausal symptoms, we evaluated the effect of a water extract of Angelica sinensis (dong quai), used for peri-or postmenopausal relief, on the proliferation of estrogen receptor-positive (MCF-7) and negative (BT-20) breast cancer cells in vitro. Design: The present study was designed to investigate the growth-modulating effect of dong quai water extract, alone or in the presence of 17β-estradiol and 4-hydroxytamoxifen, on MCF-7 and BT-20 cell cultures using MTT proliferation assay. Results: The water extract of dong quai dose-dependently and significantly stimulated the proliferation of MCF-7 cells with a weak estrogen-agonistic activity in the presence of 17β-estradiol, as evidenced by the significant suppression by 4-hydroxytamoxifen. Meanwhile, the extract significantly exerted a growth-stimulating effect on BT-20 in a dose-dependent manner with or without 17β-estradiol. No obvious difference was found in the growth of BT-20 cells treated with the extract in the presence of 17β-estradiol or 4-hydroxytamoxifen. Conclusions: The water extract of dong quai stimulated the growth of MCF-7 cells, possibly dependent of weak estrogen-agonistic activity, and augmented the BT-20 cell proliferation independent of estrogen receptor-mediated pathway. The present study provides data regarding the estrogen-like activity of dong quai, which might assist in decision making on herbal therapy use by women at risk for both estrogen-sensitive and insensitive breast cancer. Because of the lack of clinical data demonstrating the potential side effects of dong quai, its use in herbal preparations for the treatment of peri- or postmenopausal symptoms, especially in women with breast cancer, warrants caution pending further study. © 2005 The North American Menopause Society. |
Persistent Identifier | http://hdl.handle.net/10722/343011 |
ISSN | 2023 Impact Factor: 2.8 2023 SCImago Journal Rankings: 0.984 |
DC Field | Value | Language |
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dc.contributor.author | Lau, Clara B.S. | - |
dc.contributor.author | Ho, Tony C.Y. | - |
dc.contributor.author | Chan, Terry W.L. | - |
dc.contributor.author | Kim, Stephen C.F. | - |
dc.date.accessioned | 2024-05-10T09:04:45Z | - |
dc.date.available | 2024-05-10T09:04:45Z | - |
dc.date.issued | 2005 | - |
dc.identifier.citation | Menopause, 2005, v. 12, n. 6, p. 734-740 | - |
dc.identifier.issn | 1072-3714 | - |
dc.identifier.uri | http://hdl.handle.net/10722/343011 | - |
dc.description.abstract | Objective: Regarding the growing use of alternative therapies for peri- or postmenopausal symptoms, we evaluated the effect of a water extract of Angelica sinensis (dong quai), used for peri-or postmenopausal relief, on the proliferation of estrogen receptor-positive (MCF-7) and negative (BT-20) breast cancer cells in vitro. Design: The present study was designed to investigate the growth-modulating effect of dong quai water extract, alone or in the presence of 17β-estradiol and 4-hydroxytamoxifen, on MCF-7 and BT-20 cell cultures using MTT proliferation assay. Results: The water extract of dong quai dose-dependently and significantly stimulated the proliferation of MCF-7 cells with a weak estrogen-agonistic activity in the presence of 17β-estradiol, as evidenced by the significant suppression by 4-hydroxytamoxifen. Meanwhile, the extract significantly exerted a growth-stimulating effect on BT-20 in a dose-dependent manner with or without 17β-estradiol. No obvious difference was found in the growth of BT-20 cells treated with the extract in the presence of 17β-estradiol or 4-hydroxytamoxifen. Conclusions: The water extract of dong quai stimulated the growth of MCF-7 cells, possibly dependent of weak estrogen-agonistic activity, and augmented the BT-20 cell proliferation independent of estrogen receptor-mediated pathway. The present study provides data regarding the estrogen-like activity of dong quai, which might assist in decision making on herbal therapy use by women at risk for both estrogen-sensitive and insensitive breast cancer. Because of the lack of clinical data demonstrating the potential side effects of dong quai, its use in herbal preparations for the treatment of peri- or postmenopausal symptoms, especially in women with breast cancer, warrants caution pending further study. © 2005 The North American Menopause Society. | - |
dc.language | eng | - |
dc.relation.ispartof | Menopause | - |
dc.subject | Angelica sinensis | - |
dc.subject | Breast cancer | - |
dc.subject | Dong quai | - |
dc.subject | Estrogen receptor | - |
dc.subject | Herbal therapy | - |
dc.subject | Menopause | - |
dc.title | Use of dong quai (Angelica sinensis) to treat peri- or postmenopausal symptoms in women with breast cancer: Is it appropriate? | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1097/01.gme.0000184419.65943.01 | - |
dc.identifier.pmid | 16278617 | - |
dc.identifier.scopus | eid_2-s2.0-27944466104 | - |
dc.identifier.volume | 12 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 734 | - |
dc.identifier.epage | 740 | - |