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- Publisher Website: 10.1038/81792
- Scopus: eid_2-s2.0-0033680563
- PMID: 11100147
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Article: Coincidence detection in single dendritic spines mediated by calcium release
Title | Coincidence detection in single dendritic spines mediated by calcium release |
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Authors | |
Issue Date | 2000 |
Citation | Nature Neuroscience, 2000, v. 3, n. 12, p. 1266-1273 How to Cite? |
Abstract | Cerebellar long-term depression (LTD) is a calcium-dependent process in which coincident activity of parallel fiber (PF) and climbing fiber (CF) synapses causes a long-lasting decrease in PF synaptic strength onto Purkinje cells. Here we show that pairing CF activation with bursts of PF activity triggers large (> 10 μM) calcium signals in Purkinje cell dendrites. When PFs are densely activated, signals span whole dendritic branchlets and are mediated by voltage-dependent calcium entry. When PFs are sparsely activated, however, signals are restricted to single spines and blocked by metabotropic glutamate receptor antagonists. Single-spine signals and sparse-stimulation LTD are also blocked by thapsigargin, indicating that calcium must be released from stores. Single-spine signals and sparse-stimulation LTD are greatest when PF activation precedes the CF activation within 50-200 ms. This timing rule matches the properties of several forms of motor learning, providing a link between behavior and functional properties of cerebellar synaptic plasticity. |
Persistent Identifier | http://hdl.handle.net/10722/342991 |
ISSN | 2023 Impact Factor: 21.2 2023 SCImago Journal Rankings: 12.261 |
DC Field | Value | Language |
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dc.contributor.author | Wang, Samuel S.H. | - |
dc.contributor.author | Denk, Winfried | - |
dc.contributor.author | Häusser, Michael | - |
dc.date.accessioned | 2024-05-10T09:04:35Z | - |
dc.date.available | 2024-05-10T09:04:35Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | Nature Neuroscience, 2000, v. 3, n. 12, p. 1266-1273 | - |
dc.identifier.issn | 1097-6256 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342991 | - |
dc.description.abstract | Cerebellar long-term depression (LTD) is a calcium-dependent process in which coincident activity of parallel fiber (PF) and climbing fiber (CF) synapses causes a long-lasting decrease in PF synaptic strength onto Purkinje cells. Here we show that pairing CF activation with bursts of PF activity triggers large (> 10 μM) calcium signals in Purkinje cell dendrites. When PFs are densely activated, signals span whole dendritic branchlets and are mediated by voltage-dependent calcium entry. When PFs are sparsely activated, however, signals are restricted to single spines and blocked by metabotropic glutamate receptor antagonists. Single-spine signals and sparse-stimulation LTD are also blocked by thapsigargin, indicating that calcium must be released from stores. Single-spine signals and sparse-stimulation LTD are greatest when PF activation precedes the CF activation within 50-200 ms. This timing rule matches the properties of several forms of motor learning, providing a link between behavior and functional properties of cerebellar synaptic plasticity. | - |
dc.language | eng | - |
dc.relation.ispartof | Nature Neuroscience | - |
dc.title | Coincidence detection in single dendritic spines mediated by calcium release | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1038/81792 | - |
dc.identifier.pmid | 11100147 | - |
dc.identifier.scopus | eid_2-s2.0-0033680563 | - |
dc.identifier.volume | 3 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 1266 | - |
dc.identifier.epage | 1273 | - |