File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/0896-6273(95)90152-3
- Scopus: eid_2-s2.0-0029081514
- PMID: 7546743
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons
Title | Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons |
---|---|
Authors | |
Issue Date | 1995 |
Citation | Neuron, 1995, v. 15, n. 3, p. 637-647 How to Cite? |
Abstract | The site of action potential initiation in substantia nigra neurons was investigated by using simultaneous somatic and dendritic whole-cell recording in brain slices. In many dopamine neurons, action potentials were observed first at the dendritic recording site. Anatomical reconstruction showed that in these neurons, the axon emerged from the dendrite from which the recording had been made. Action potentials showed little attenuation in the dendritic tree, which in dopamine neurons was shown to be due to recruitment of dendritic sodium channels and may be related to the dendritic release of dopamine. We conclude that in substantia nigra neurons, the site of action potential initiation, and thus the final site of synaptic integration, is in the axon. As the axon can originate from a dendrite, up to 240 μm away from the soma, synaptic input to the axon-bearing dendrite may be privileged with respect to its ability to influence action potential initiation. © 1995. |
Persistent Identifier | http://hdl.handle.net/10722/342987 |
ISSN | 2023 Impact Factor: 14.7 2023 SCImago Journal Rankings: 7.728 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Häusser, Michael | - |
dc.contributor.author | Stuart, Greg | - |
dc.contributor.author | Racca, Claudia | - |
dc.contributor.author | Sakmann, Bert | - |
dc.date.accessioned | 2024-05-10T09:04:33Z | - |
dc.date.available | 2024-05-10T09:04:33Z | - |
dc.date.issued | 1995 | - |
dc.identifier.citation | Neuron, 1995, v. 15, n. 3, p. 637-647 | - |
dc.identifier.issn | 0896-6273 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342987 | - |
dc.description.abstract | The site of action potential initiation in substantia nigra neurons was investigated by using simultaneous somatic and dendritic whole-cell recording in brain slices. In many dopamine neurons, action potentials were observed first at the dendritic recording site. Anatomical reconstruction showed that in these neurons, the axon emerged from the dendrite from which the recording had been made. Action potentials showed little attenuation in the dendritic tree, which in dopamine neurons was shown to be due to recruitment of dendritic sodium channels and may be related to the dendritic release of dopamine. We conclude that in substantia nigra neurons, the site of action potential initiation, and thus the final site of synaptic integration, is in the axon. As the axon can originate from a dendrite, up to 240 μm away from the soma, synaptic input to the axon-bearing dendrite may be privileged with respect to its ability to influence action potential initiation. © 1995. | - |
dc.language | eng | - |
dc.relation.ispartof | Neuron | - |
dc.title | Axonal initiation and active dendritic propagation of action potentials in substantia nigra neurons | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0896-6273(95)90152-3 | - |
dc.identifier.pmid | 7546743 | - |
dc.identifier.scopus | eid_2-s2.0-0029081514 | - |
dc.identifier.volume | 15 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 637 | - |
dc.identifier.epage | 647 | - |