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- Publisher Website: 10.1016/0006-291X(91)91504-6
- Scopus: eid_2-s2.0-0026089920
- PMID: 1899575
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Article: Activation by cromakalim of pre- and post-synaptic ATP-sensitive K+ channels in substantia nigra
Title | Activation by cromakalim of pre- and post-synaptic ATP-sensitive K+ channels in substantia nigra |
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Authors | |
Issue Date | 1991 |
Citation | Biochemical and Biophysical Research Communications, 1991, v. 174, n. 2, p. 909-914 How to Cite? |
Abstract | Membrane potentials and synaptic potentials were recorded using the patch clamp technique from neurons isolated from the substantia nigra. Intracellular perfusion of dopaminergic neurons with an ATP-free solution caused hyperpolarization and inhibition of firing. Intracellular perfusion with a solution containing 2 mM ATP prevented this hyperpolarization, but application of the K+ channel openers cromakalim and pinacidil caused a similar hyperpolarization as well as the disappearance of bicuculline-sensitive synaptic potentials. All these effects were reversed by sulfonylureas, indicating that they are mediated by ATP-sensitive K+ channels. It is concluded that K+ channel openers activate ATP-sensitive K+ channels both presynaptically on GABAergic terminals and postsynaptically on substantia nigra dopaminergic neurons. © 1991. |
Persistent Identifier | http://hdl.handle.net/10722/342983 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
DC Field | Value | Language |
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dc.contributor.author | Häusser, Michael A. | - |
dc.contributor.author | de Weille, Jan R. | - |
dc.contributor.author | Lazdunski, Michel | - |
dc.date.accessioned | 2024-05-10T09:04:31Z | - |
dc.date.available | 2024-05-10T09:04:31Z | - |
dc.date.issued | 1991 | - |
dc.identifier.citation | Biochemical and Biophysical Research Communications, 1991, v. 174, n. 2, p. 909-914 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/10722/342983 | - |
dc.description.abstract | Membrane potentials and synaptic potentials were recorded using the patch clamp technique from neurons isolated from the substantia nigra. Intracellular perfusion of dopaminergic neurons with an ATP-free solution caused hyperpolarization and inhibition of firing. Intracellular perfusion with a solution containing 2 mM ATP prevented this hyperpolarization, but application of the K+ channel openers cromakalim and pinacidil caused a similar hyperpolarization as well as the disappearance of bicuculline-sensitive synaptic potentials. All these effects were reversed by sulfonylureas, indicating that they are mediated by ATP-sensitive K+ channels. It is concluded that K+ channel openers activate ATP-sensitive K+ channels both presynaptically on GABAergic terminals and postsynaptically on substantia nigra dopaminergic neurons. © 1991. | - |
dc.language | eng | - |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | - |
dc.title | Activation by cromakalim of pre- and post-synaptic ATP-sensitive K+ channels in substantia nigra | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.1016/0006-291X(91)91504-6 | - |
dc.identifier.pmid | 1899575 | - |
dc.identifier.scopus | eid_2-s2.0-0026089920 | - |
dc.identifier.volume | 174 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 909 | - |
dc.identifier.epage | 914 | - |
dc.identifier.eissn | 1090-2104 | - |