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- Publisher Website: 10.3390/cancers16071339
- Scopus: eid_2-s2.0-85189985500
- WOS: WOS:001201609600001
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Article: Cancer-Causing Effects of Orthopaedic Metal Implants in Total Hip Arthroplasty
Title | Cancer-Causing Effects of Orthopaedic Metal Implants in Total Hip Arthroplasty |
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Authors | |
Keywords | carcinogenicity chromium cobalt orthopaedic implants titanium total hip arthroplasty |
Issue Date | 29-Mar-2024 |
Publisher | Multidisciplinary Digital Publishing Institute (MDPI) |
Citation | Cancers, 2024, v. 16, n. 7 How to Cite? |
Abstract | Background: Metal implants have been preferentially used in THA due to its biocompatibility, mechanical stability and durability. Yet concerns have emerged regarding their potential to release metallic ions, leading to long-term adverse effects, including carcinogenicity. This study aimed to investigate the risk of cancer development in patients with orthopaedic metal implants in total hip arthroplasty (THA). Methods: Patients with THA conducted at a local tertiary implant centre from 2001–2008 were linked to the local cancer registry and followed up to the end of 2023. Standardized incidence ratios (SIRs) for cancer incidence and its confidence interval by Poisson distribution were calculated. Survival analysis was depicted using the Kaplan–Meier method, and the log-rank test was used to assess the differences across groups. Results: The study cohort included 388 patients and 53 cancers diagnosed during follow-up, at least 5 years post THA. All-site cancer risks were increased in patients with THA (SIR: 1.97; 95% CI: 1.48–2.46), validated with chi-square analysis (chi-square = 15.2551, N = 100,388, p < 0.01). A statistically significant increase in multiple site-specific cancers including haematological cancers were identified. Conclusions: Patients with THA were found to have an increased risk for cancer compared to the general population during a mean follow-up of 16 years. |
Persistent Identifier | http://hdl.handle.net/10722/342778 |
ISSN | 2021 Impact Factor: 6.575 2020 SCImago Journal Rankings: 1.818 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Sun, Cherry W Y | - |
dc.contributor.author | Lau, Lawrence C M | - |
dc.contributor.author | Cheung, Jason P Y | - |
dc.contributor.author | Choi, Siu-Wai | - |
dc.date.accessioned | 2024-04-24T02:47:06Z | - |
dc.date.available | 2024-04-24T02:47:06Z | - |
dc.date.issued | 2024-03-29 | - |
dc.identifier.citation | Cancers, 2024, v. 16, n. 7 | - |
dc.identifier.issn | 2072-6694 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342778 | - |
dc.description.abstract | <p>Background: Metal implants have been preferentially used in THA due to its biocompatibility, mechanical stability and durability. Yet concerns have emerged regarding their potential to release metallic ions, leading to long-term adverse effects, including carcinogenicity. This study aimed to investigate the risk of cancer development in patients with orthopaedic metal implants in total hip arthroplasty (THA). Methods: Patients with THA conducted at a local tertiary implant centre from 2001–2008 were linked to the local cancer registry and followed up to the end of 2023. Standardized incidence ratios (SIRs) for cancer incidence and its confidence interval by Poisson distribution were calculated. Survival analysis was depicted using the Kaplan–Meier method, and the log-rank test was used to assess the differences across groups. Results: The study cohort included 388 patients and 53 cancers diagnosed during follow-up, at least 5 years post THA. All-site cancer risks were increased in patients with THA (SIR: 1.97; 95% CI: 1.48–2.46), validated with chi-square analysis (chi-square = 15.2551, N = 100,388, p < 0.01). A statistically significant increase in multiple site-specific cancers including haematological cancers were identified. Conclusions: Patients with THA were found to have an increased risk for cancer compared to the general population during a mean follow-up of 16 years.</p> | - |
dc.language | eng | - |
dc.publisher | Multidisciplinary Digital Publishing Institute (MDPI) | - |
dc.relation.ispartof | Cancers | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | carcinogenicity | - |
dc.subject | chromium | - |
dc.subject | cobalt | - |
dc.subject | orthopaedic implants | - |
dc.subject | titanium | - |
dc.subject | total hip arthroplasty | - |
dc.title | Cancer-Causing Effects of Orthopaedic Metal Implants in Total Hip Arthroplasty | - |
dc.type | Article | - |
dc.identifier.doi | 10.3390/cancers16071339 | - |
dc.identifier.scopus | eid_2-s2.0-85189985500 | - |
dc.identifier.volume | 16 | - |
dc.identifier.issue | 7 | - |
dc.identifier.isi | WOS:001201609600001 | - |
dc.identifier.issnl | 2072-6694 | - |