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Article: Surgical margin and local recurrence of ductal carcinoma in situ
Title | Surgical margin and local recurrence of ductal carcinoma in situ |
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Authors | |
Keywords | Ductal carcinoma in situ Local recurrence Surgical margin |
Issue Date | 1-Feb-2024 |
Citation | Cancer Treatment and Research Communications, 2024, v. 39 How to Cite? |
Abstract | PurposeThis study aims to evaluate the association between surgical margin status and local recurrence of DCIS. MethodsA retrospective analysis of a prospectively maintained 20-year DCIS database was performed. >=2 mm margin was defined as clear margin. Local relapse rate between the patients with clear versus close margins were analyzed with Kaplan-Meier analyses. Results654 patients were analyzed. Median age was 46.5 (Range 18 – 80). 205 (31.3%) were high grade, 194 (29.7%) were intermediate grade, 143 (21.9%) were low grade. 112 (18.3%) were unknown. 202 (30.9%) were estrogen receptor positive, 49 (7.4%) were negative, 403 (61.6%) patients were unknown. 403 (61.6%) patients received mastectomy while 251 (38.4%) patients received BCS and radiotherapy. 549 (83.9%) patients had clear surgical margin, 50 (7.7%) patients had involved (positive) resection margin, 55 (8.4%) had close margin (<2 mm margin). All patients with involved margin received re-excision of margin, while 21 patients (out of 55 who had close resection margins) received re-excision of margin. Negative surgical margins were achieved after the re-excision. 34 patients with close resection margin decided not to receive re-excision but to undergo adjuvant radiotherapy. After median follow-up of 128 months, the 10-year ipsilateral breast tumor relapse (IBTR) was 4.5% (N = 28), Of which 27 (96.4%) patients had clear margin after the initial surgical treatment of DCIS. 1 (3.6%) patient had close surgical margin. Difference in IBTR between the two groups was not statistically significant (p = 0.692). ConclusionClose surgical margin for DCIS is not associated with increased risk of IBTR. |
Persistent Identifier | http://hdl.handle.net/10722/342768 |
ISSN | 2023 SCImago Journal Rankings: 0.793 |
DC Field | Value | Language |
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dc.contributor.author | Co, THM | - |
dc.contributor.author | Fung, Maggie Wai Yin | - |
dc.contributor.author | Kwong, A | - |
dc.date.accessioned | 2024-04-24T02:47:01Z | - |
dc.date.available | 2024-04-24T02:47:01Z | - |
dc.date.issued | 2024-02-01 | - |
dc.identifier.citation | Cancer Treatment and Research Communications, 2024, v. 39 | - |
dc.identifier.issn | 2468-2942 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342768 | - |
dc.description.abstract | <h3>Purpose</h3><p>This study aims to evaluate the association between surgical margin status and local recurrence of DCIS.</p><h3>Methods</h3><p>A retrospective analysis of a prospectively maintained 20-year DCIS database was performed. >=2 mm margin was defined as clear margin. Local relapse rate between the patients with clear versus close margins were analyzed with Kaplan-Meier analyses.</p><h3>Results</h3><p>654 patients were analyzed. Median age was 46.5 (Range 18 – 80). 205 (31.3%) were high grade, 194 (29.7%) were intermediate grade, 143 (21.9%) were low grade. 112 (18.3%) were unknown. 202 (30.9%) were estrogen receptor positive, 49 (7.4%) were negative, 403 (61.6%) patients were unknown.</p><p>403 (61.6%) patients received mastectomy while 251 (38.4%) patients received BCS and radiotherapy. 549 (83.9%) patients had clear surgical margin, 50 (7.7%) patients had involved (positive) resection margin, 55 (8.4%) had close margin (<2 mm margin). All patients with involved margin received re-excision of margin, while 21 patients (out of 55 who had close resection margins) received re-excision of margin. Negative surgical margins were achieved after the re-excision. 34 patients with close resection margin decided not to receive re-excision but to undergo adjuvant radiotherapy.</p><p>After median follow-up of 128 months, the 10-year ipsilateral breast tumor relapse (IBTR) was 4.5% (N = 28), Of which 27 (96.4%) patients had clear margin after the initial surgical treatment of DCIS. 1 (3.6%) patient had close surgical margin. Difference in IBTR between the two groups was not statistically significant (p = 0.692).</p><h3>Conclusion</h3><p>Close surgical margin for DCIS is not associated with increased risk of IBTR.<span> </span></p> | - |
dc.language | eng | - |
dc.relation.ispartof | Cancer Treatment and Research Communications | - |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. | - |
dc.subject | Ductal carcinoma in situ | - |
dc.subject | Local recurrence | - |
dc.subject | Surgical margin | - |
dc.title | Surgical margin and local recurrence of ductal carcinoma in situ | - |
dc.type | Article | - |
dc.identifier.doi | 10.1016/j.ctarc.2024.100793 | - |
dc.identifier.scopus | eid_2-s2.0-85184589261 | - |
dc.identifier.volume | 39 | - |
dc.identifier.issnl | 2468-2942 | - |