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Article: Therapeutic modulation of microbiota-host metabolic interactions

TitleTherapeutic modulation of microbiota-host metabolic interactions
Authors
Issue Date2012
Citation
Science Translational Medicine, 2012, v. 4, n. 137, article no. 137rv6 How to Cite?
AbstractThe complex metabolic relationships between the host and its microbiota change throughout life and vary extensively between individuals, affecting disease risk factors and therapeutic responses through drug metabolism. Elucidating the biochemical mechanisms underlying this human supraorganism symbiosis is yielding new therapeutic insights to improve human health, treat disease, and potentially modify human disease risk factors. Therapeutic options include targeting drugs to microbial genes or co-regulated host pathways and modifying the gut microbiota through diet, probiotic and prebiotic interventions, bariatric surgery, fecal transplants, or ecological engineering. The age-associated co-development of the host and its microbiota provides a series of windows for therapeutic intervention from early life through old age.
Persistent Identifierhttp://hdl.handle.net/10722/342727
ISSN
2023 Impact Factor: 15.8
2023 SCImago Journal Rankings: 6.510
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorHolmes, Elaine-
dc.contributor.authorKinross, James-
dc.contributor.authorGibson, Glenn R.-
dc.contributor.authorBurcelin, Remy-
dc.contributor.authorJia, Wei-
dc.contributor.authorPettersson, Sven-
dc.contributor.authorNicholson, Jeremy K.-
dc.date.accessioned2024-04-17T07:05:50Z-
dc.date.available2024-04-17T07:05:50Z-
dc.date.issued2012-
dc.identifier.citationScience Translational Medicine, 2012, v. 4, n. 137, article no. 137rv6-
dc.identifier.issn1946-6234-
dc.identifier.urihttp://hdl.handle.net/10722/342727-
dc.description.abstractThe complex metabolic relationships between the host and its microbiota change throughout life and vary extensively between individuals, affecting disease risk factors and therapeutic responses through drug metabolism. Elucidating the biochemical mechanisms underlying this human supraorganism symbiosis is yielding new therapeutic insights to improve human health, treat disease, and potentially modify human disease risk factors. Therapeutic options include targeting drugs to microbial genes or co-regulated host pathways and modifying the gut microbiota through diet, probiotic and prebiotic interventions, bariatric surgery, fecal transplants, or ecological engineering. The age-associated co-development of the host and its microbiota provides a series of windows for therapeutic intervention from early life through old age.-
dc.languageeng-
dc.relation.ispartofScience Translational Medicine-
dc.titleTherapeutic modulation of microbiota-host metabolic interactions-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1126/scitranslmed.3004244-
dc.identifier.pmid22674556-
dc.identifier.scopuseid_2-s2.0-84861992769-
dc.identifier.volume4-
dc.identifier.issue137-
dc.identifier.spagearticle no. 137rv6-
dc.identifier.epagearticle no. 137rv6-
dc.identifier.eissn1946-6242-
dc.identifier.isiWOS:000305075700013-

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