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Article: Metabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride

TitleMetabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride
Authors
KeywordsAcute liver injure
Carbon tetrachloride
Diammonium glycyrrhizinate
Metabolomics
Issue Date2011
Citation
Metabolomics, 2011, v. 7, n. 2, p. 226-236 How to Cite?
AbstractDiammonium glycyrrhizinate (DG), a constitutent of Glycyrrhiza uralensis, has a protective effect on hepatic injury, hepatisis and cirrhosis. To date, the mechanism has been poorly understood, especially at the metabolic level. A metabolomic profiling study was performed to characterize the carbon tetrachloride (CCl4) induced global metabolic alteration and the protective effects of DG in Sprague-Dawley rats. Urinary and hepatic tissue metabolic profiling revealed that CCl4 perturbed the amino acid metabolism (alanine, glycine, leucine), tricarboxylic acid cycle (citrate), lipid metabolism (unsaturated fatty acids) and gut microbiota related metabolites. Our results also indicated that DG was able to attenuate CCl4 perturbed metabolic pathways and ameliorated biochemical markers of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Total cholesterol (TCHO). This global metabolomic approach also revealed full metabolic recovery takes longer than apparent and conventional histological and biochemical markers. © 2010 Springer Science+Business Media, LLC.
Persistent Identifierhttp://hdl.handle.net/10722/342724
ISSN
2023 Impact Factor: 3.5
2023 SCImago Journal Rankings: 0.740
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorWang, Xiaoyan-
dc.contributor.authorLin, Jingchao-
dc.contributor.authorChen, Tianlu-
dc.contributor.authorZhou, Mingmei-
dc.contributor.authorSu, Mingming-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:05:48Z-
dc.date.available2024-04-17T07:05:48Z-
dc.date.issued2011-
dc.identifier.citationMetabolomics, 2011, v. 7, n. 2, p. 226-236-
dc.identifier.issn1573-3882-
dc.identifier.urihttp://hdl.handle.net/10722/342724-
dc.description.abstractDiammonium glycyrrhizinate (DG), a constitutent of Glycyrrhiza uralensis, has a protective effect on hepatic injury, hepatisis and cirrhosis. To date, the mechanism has been poorly understood, especially at the metabolic level. A metabolomic profiling study was performed to characterize the carbon tetrachloride (CCl4) induced global metabolic alteration and the protective effects of DG in Sprague-Dawley rats. Urinary and hepatic tissue metabolic profiling revealed that CCl4 perturbed the amino acid metabolism (alanine, glycine, leucine), tricarboxylic acid cycle (citrate), lipid metabolism (unsaturated fatty acids) and gut microbiota related metabolites. Our results also indicated that DG was able to attenuate CCl4 perturbed metabolic pathways and ameliorated biochemical markers of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and Total cholesterol (TCHO). This global metabolomic approach also revealed full metabolic recovery takes longer than apparent and conventional histological and biochemical markers. © 2010 Springer Science+Business Media, LLC.-
dc.languageeng-
dc.relation.ispartofMetabolomics-
dc.subjectAcute liver injure-
dc.subjectCarbon tetrachloride-
dc.subjectDiammonium glycyrrhizinate-
dc.subjectMetabolomics-
dc.titleMetabolic profiling reveals the protective effect of diammonium glycyrrhizinate on acute hepatic injury induced by carbon tetrachloride-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11306-010-0244-5-
dc.identifier.scopuseid_2-s2.0-79957498275-
dc.identifier.volume7-
dc.identifier.issue2-
dc.identifier.spage226-
dc.identifier.epage236-
dc.identifier.eissn1573-3890-
dc.identifier.isiWOS:000290813000006-

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