File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Metabonomic study on the biochemical profiles of a hydrocortisone-induced animal model

TitleMetabonomic study on the biochemical profiles of a hydrocortisone-induced animal model
Authors
KeywordsGC/MS
Hydrocortisone
Kidney-deficiency
Metabolic syndrome
Metabonomics
Issue Date2005
Citation
Journal of Proteome Research, 2005, v. 4, n. 6, p. 2391-2396 How to Cite?
AbstractThis work describes the metabonomic study of a biochemical modification in vivo induced by high dose of hydrocortisone, which led to a unique pathologic condition similar to the 'kidney deficiency syndromes', an early stage of obesity and diabetes in traditional Chinese medicine. The methodology of the metabonomic approach consisted of GC/MS and multivariate statistical technique for the establishment of urine metabolic patterns of the treatment rats. In the study, 24-h urine was collected pre-dose and at days 1, 3, 7, and 10 post-dose after rats were injected with hydrocortisone at 1.5 mg/ 100 g. The acquired data were transferred into Matlab to be processed using principal components analysis (PCA). The results indicated that clear and consistent biochemical changes following hydrocortisone intervention under controlled conditions could be identified using chemometric analysis. The work suggests that this metabonomic approach could be used as a potentially powerful tool to investigate the biochemical changes of certain physiopathologic conditions such as metabolic syndrome, as an early diagnostic means. © 2005 American Chemical Society.
Persistent Identifierhttp://hdl.handle.net/10722/342722
ISSN
2023 Impact Factor: 3.8
2023 SCImago Journal Rankings: 1.299
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorChen, Minjun-
dc.contributor.authorZhao, Liping-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:05:47Z-
dc.date.available2024-04-17T07:05:47Z-
dc.date.issued2005-
dc.identifier.citationJournal of Proteome Research, 2005, v. 4, n. 6, p. 2391-2396-
dc.identifier.issn1535-3893-
dc.identifier.urihttp://hdl.handle.net/10722/342722-
dc.description.abstractThis work describes the metabonomic study of a biochemical modification in vivo induced by high dose of hydrocortisone, which led to a unique pathologic condition similar to the 'kidney deficiency syndromes', an early stage of obesity and diabetes in traditional Chinese medicine. The methodology of the metabonomic approach consisted of GC/MS and multivariate statistical technique for the establishment of urine metabolic patterns of the treatment rats. In the study, 24-h urine was collected pre-dose and at days 1, 3, 7, and 10 post-dose after rats were injected with hydrocortisone at 1.5 mg/ 100 g. The acquired data were transferred into Matlab to be processed using principal components analysis (PCA). The results indicated that clear and consistent biochemical changes following hydrocortisone intervention under controlled conditions could be identified using chemometric analysis. The work suggests that this metabonomic approach could be used as a potentially powerful tool to investigate the biochemical changes of certain physiopathologic conditions such as metabolic syndrome, as an early diagnostic means. © 2005 American Chemical Society.-
dc.languageeng-
dc.relation.ispartofJournal of Proteome Research-
dc.subjectGC/MS-
dc.subjectHydrocortisone-
dc.subjectKidney-deficiency-
dc.subjectMetabolic syndrome-
dc.subjectMetabonomics-
dc.titleMetabonomic study on the biochemical profiles of a hydrocortisone-induced animal model-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1021/pr050158o-
dc.identifier.pmid16335992-
dc.identifier.scopuseid_2-s2.0-29144486833-
dc.identifier.volume4-
dc.identifier.issue6-
dc.identifier.spage2391-
dc.identifier.epage2396-
dc.identifier.isiWOS:000234007200059-

Export via OAI-PMH Interface in XML Formats


OR


Export to Other Non-XML Formats