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Article: Bile acid signaling in the regulation of whole body metabolic and immunological homeostasis

TitleBile acid signaling in the regulation of whole body metabolic and immunological homeostasis
Authors
Keywordsbile acid
immunity
metabolism
whole body
Issue Date2023
Citation
Science China Life Sciences, 2023 How to Cite?
AbstractBile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.
Persistent Identifierhttp://hdl.handle.net/10722/342677
ISSN
2023 Impact Factor: 8.0
2023 SCImago Journal Rankings: 1.888
ISI Accession Number ID

 

DC FieldValueLanguage
dc.contributor.authorJia, Wei-
dc.contributor.authorLi, Yitao-
dc.contributor.authorCheung, Kenneth C.P.-
dc.contributor.authorZheng, Xiaojiao-
dc.date.accessioned2024-04-17T07:05:28Z-
dc.date.available2024-04-17T07:05:28Z-
dc.date.issued2023-
dc.identifier.citationScience China Life Sciences, 2023-
dc.identifier.issn1674-7305-
dc.identifier.urihttp://hdl.handle.net/10722/342677-
dc.description.abstractBile acids (BAs) play a crucial role in nutrient absorption and act as key regulators of lipid and glucose metabolism and immune homeostasis. Through the enterohepatic circulation, BAs are synthesized, metabolized, and reabsorbed, with a portion entering the vascular circulation and distributing systemically. This allows BAs to interact with receptors in all major organs, leading to organ-organ interactions that regulate both local and global metabolic processes, as well as the immune system. This review focuses on the whole-body effects of BA-mediated metabolic and immunological regulation, including in the brain, heart, liver, intestine, eyes, skin, adipose tissue, and muscle. Targeting BA synthesis and receptor signaling is a promising strategy for the development of novel therapies for various diseases throughout the body.-
dc.languageeng-
dc.relation.ispartofScience China Life Sciences-
dc.subjectbile acid-
dc.subjectimmunity-
dc.subjectmetabolism-
dc.subjectwhole body-
dc.titleBile acid signaling in the regulation of whole body metabolic and immunological homeostasis-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.1007/s11427-023-2353-0-
dc.identifier.scopuseid_2-s2.0-85166207268-
dc.identifier.eissn1869-1889-
dc.identifier.isiWOS:001039257900002-

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