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- Publisher Website: 10.3390/ijms241411422
- Scopus: eid_2-s2.0-85165951279
- PMID: 37511184
- WOS: WOS:001038598000001
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Article: An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow’s Milk Protein Allergy
Title | An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow’s Milk Protein Allergy |
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Authors | |
Keywords | amino acids bile acids fecal community type human milk oligosaccharides metabolomics metagenomics microbiome short-chain fatty acids |
Issue Date | 2023 |
Citation | International Journal of Molecular Sciences, 2023, v. 24, n. 14, article no. 11422 How to Cite? |
Abstract | Cow’s milk protein allergy (CMPA) is a prevalent food allergy among infants and young children. We conducted a randomized, multicenter intervention study involving 194 non-breastfed infants with CMPA until 12 months of age (clinical trial registration: NCT03085134). One exploratory objective was to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome in this population. Thus, fecal samples were collected at baseline, 1 and 3 months from enrollment, as well as at 12 months of age. Human milk oligosaccharides (HMO) supplementation led to the enrichment of bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition toward an adult-like pattern. We identified specific HMO-mediated changes in fecal amino acid degradation and bile acid conjugation, particularly in infants commencing the HMO-supplemented formula before the age of three months. Thus, HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA. Further investigation is necessary to determine the clinical significance of these findings in terms of a reduced incidence of respiratory infections and other potential health benefits. |
Persistent Identifier | http://hdl.handle.net/10722/342676 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.179 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Boulangé, Claire L. | - |
dc.contributor.author | Pedersen, Helle K. | - |
dc.contributor.author | Martin, Francois Pierre | - |
dc.contributor.author | Siegwald, Léa | - |
dc.contributor.author | Pallejà Caro, Albert | - |
dc.contributor.author | Eklund, Aron C. | - |
dc.contributor.author | Jia, Wei | - |
dc.contributor.author | Zhang, Huizhen | - |
dc.contributor.author | Berger, Bernard | - |
dc.contributor.author | Sprenger, Norbert | - |
dc.contributor.author | Heine, Ralf G. | - |
dc.date.accessioned | 2024-04-17T07:05:28Z | - |
dc.date.available | 2024-04-17T07:05:28Z | - |
dc.date.issued | 2023 | - |
dc.identifier.citation | International Journal of Molecular Sciences, 2023, v. 24, n. 14, article no. 11422 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | http://hdl.handle.net/10722/342676 | - |
dc.description.abstract | Cow’s milk protein allergy (CMPA) is a prevalent food allergy among infants and young children. We conducted a randomized, multicenter intervention study involving 194 non-breastfed infants with CMPA until 12 months of age (clinical trial registration: NCT03085134). One exploratory objective was to assess the effects of a whey-based extensively hydrolyzed formula (EHF) supplemented with 2′-fucosyllactose (2′-FL) and lacto-N-neotetraose (LNnT) on the fecal microbiome and metabolome in this population. Thus, fecal samples were collected at baseline, 1 and 3 months from enrollment, as well as at 12 months of age. Human milk oligosaccharides (HMO) supplementation led to the enrichment of bifidobacteria in the gut microbiome and delayed the shift of the microbiome composition toward an adult-like pattern. We identified specific HMO-mediated changes in fecal amino acid degradation and bile acid conjugation, particularly in infants commencing the HMO-supplemented formula before the age of three months. Thus, HMO supplementation partially corrected the dysbiosis commonly observed in infants with CMPA. Further investigation is necessary to determine the clinical significance of these findings in terms of a reduced incidence of respiratory infections and other potential health benefits. | - |
dc.language | eng | - |
dc.relation.ispartof | International Journal of Molecular Sciences | - |
dc.subject | amino acids | - |
dc.subject | bile acids | - |
dc.subject | fecal community type | - |
dc.subject | human milk oligosaccharides | - |
dc.subject | metabolomics | - |
dc.subject | metagenomics | - |
dc.subject | microbiome | - |
dc.subject | short-chain fatty acids | - |
dc.title | An Extensively Hydrolyzed Formula Supplemented with Two Human Milk Oligosaccharides Modifies the Fecal Microbiome and Metabolome in Infants with Cow’s Milk Protein Allergy | - |
dc.type | Article | - |
dc.description.nature | link_to_subscribed_fulltext | - |
dc.identifier.doi | 10.3390/ijms241411422 | - |
dc.identifier.pmid | 37511184 | - |
dc.identifier.scopus | eid_2-s2.0-85165951279 | - |
dc.identifier.volume | 24 | - |
dc.identifier.issue | 14 | - |
dc.identifier.spage | article no. 11422 | - |
dc.identifier.epage | article no. 11422 | - |
dc.identifier.eissn | 1422-0067 | - |
dc.identifier.isi | WOS:001038598000001 | - |