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Article: Alterations in bile acid levels in metabolic diseases and related treatment strategies

TitleAlterations in bile acid levels in metabolic diseases and related treatment strategies
Authors
KeywordsBile acid
Biomarker
Farnesoid X receptor (FXR)
G-protein-coupled bile acid receptor 1
Metabolic disease
Issue Date2019
Citation
Journal of Shanghai Jiaotong University (Medical Science), 2019, v. 39, n. 6, p. 678-683 How to Cite?
AbstractBile acid as a signaling molecule can specifically bind to bile acid receptors (such as farnesoid X receptor and G-protein-coupled bile acid receptor) to mediate a series of biological regulation reactions. In recent years, it has been found that bile acids are widely involved in glucose metabolism, lipid metabolism and energy metabolism. The development of metabolic diseases is usually accompanied by the changes of bile acid profiles and receptors, and thus bile acids may be applied as potential biomarkers for clinical diagnosis, prediction, and evaluation of therapeutic effects. This article reviews the relationship between bile acids and metabolic diseases, and the treatment of metabolic diseases based on the regulation of bile acid metabolism.
Persistent Identifierhttp://hdl.handle.net/10722/342591
ISSN
2023 SCImago Journal Rankings: 0.110

 

DC FieldValueLanguage
dc.contributor.authorKuang, Jun Liang-
dc.contributor.authorZheng, Xiao Jiao-
dc.contributor.authorZhao, Ai Hua-
dc.contributor.authorJia, Wei-
dc.date.accessioned2024-04-17T07:04:53Z-
dc.date.available2024-04-17T07:04:53Z-
dc.date.issued2019-
dc.identifier.citationJournal of Shanghai Jiaotong University (Medical Science), 2019, v. 39, n. 6, p. 678-683-
dc.identifier.issn1674-8115-
dc.identifier.urihttp://hdl.handle.net/10722/342591-
dc.description.abstractBile acid as a signaling molecule can specifically bind to bile acid receptors (such as farnesoid X receptor and G-protein-coupled bile acid receptor) to mediate a series of biological regulation reactions. In recent years, it has been found that bile acids are widely involved in glucose metabolism, lipid metabolism and energy metabolism. The development of metabolic diseases is usually accompanied by the changes of bile acid profiles and receptors, and thus bile acids may be applied as potential biomarkers for clinical diagnosis, prediction, and evaluation of therapeutic effects. This article reviews the relationship between bile acids and metabolic diseases, and the treatment of metabolic diseases based on the regulation of bile acid metabolism.-
dc.languageeng-
dc.relation.ispartofJournal of Shanghai Jiaotong University (Medical Science)-
dc.subjectBile acid-
dc.subjectBiomarker-
dc.subjectFarnesoid X receptor (FXR)-
dc.subjectG-protein-coupled bile acid receptor 1-
dc.subjectMetabolic disease-
dc.titleAlterations in bile acid levels in metabolic diseases and related treatment strategies-
dc.typeArticle-
dc.description.naturelink_to_subscribed_fulltext-
dc.identifier.doi10.3969/j.issn.1674-8115.2019.06.019-
dc.identifier.scopuseid_2-s2.0-85070881450-
dc.identifier.volume39-
dc.identifier.issue6-
dc.identifier.spage678-
dc.identifier.epage683-

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